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Volumn 48, Issue 6, 2009, Pages 479-487

Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet

Author keywords

Apoptosis; Hepatocarcinogenesis; microRNAs; p53

Indexed keywords

CHOLINE; FOLIC ACID; METHIONINE; METHYL GROUP; MICRORNA; NOTCH1 RECEPTOR; PROTEIN BCL 2; PROTEIN BCL 6; TRANSCRIPTION FACTOR E2F3;

EID: 65749109370     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20484     Document Type: Article
Times cited : (137)

References (56)
  • 1
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
    • DOI 10.1016/S0092-8674(04)00045-5
    • Bartel DP. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 2004;116:281-297. (Pubitemid 38167318)
    • (2004) Cell , vol.116 , Issue.2 , pp. 281-297
    • Bartel, D.P.1
  • 2
    • 33644659734 scopus 로고    scopus 로고
    • Mammalian microRNAs: A small world for fine-tuning gene expression
    • Sevignani C, Calin GA, Siracusa LD, Croce CM. Mammalian microRNAs: A small world for fine-tuning gene expression. Mamm Genome 2006;17:189-202.
    • (2006) Mamm Genome , vol.17 , pp. 189-202
    • Sevignani, C.1    Calin, G.A.2    Siracusa, L.D.3    Croce, C.M.4
  • 4
    • 33645321647 scopus 로고    scopus 로고
    • MicroRNAs in cell proliferation, cell death, and tumorigenesis
    • Hwang H-W, Mendell JT. MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 2006;94:776-780.
    • (2006) Br J Cancer , vol.94 , pp. 776-780
    • Hwang, H.-W.1    Mendell, J.T.2
  • 5
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70. (Pubitemid 30046295)
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 6
    • 0035902115 scopus 로고    scopus 로고
    • Proliferation, cell cycle and apoptosis in cancer
    • Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature 2001;411:342-348.
    • (2001) Nature , vol.411 , pp. 342-348
    • Evan, G.I.1    Vousden, K.H.2
  • 7
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of microRNA genes miR15 and miR16 at 13q14 in chronic lymphatic leukemia
    • Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of microRNA genes miR15 and miR16 at 13q14 in chronic lymphatic leukemia. Proc Natl Acad Sci USA 2002;99:15524-15529.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3
  • 8
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature 2005;435:834-838.
    • (2005) Nature , vol.435 , pp. 834-838
    • Lu, J.1    Getz, G.2    Miska, E.A.3
  • 9
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • DOI 10.1038/nrc1997, PII NRC1997
    • Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006;6:857-866. (Pubitemid 44629897)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.11 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 10
    • 33646157967 scopus 로고    scopus 로고
    • Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues
    • Murakami Y, Yasuda T, Saigo K, et al. Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene 2006;25:2537-2545.
    • (2006) Oncogene , vol.25 , pp. 2537-2545
    • Murakami, Y.1    Yasuda, T.2    Saigo, K.3
  • 11
    • 34447117003 scopus 로고    scopus 로고
    • Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma
    • Gramantieri L, Ferracin M, Fornari F, et al. Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. Cancer Res 2007; 67:6092-6099.
    • (2007) Cancer Res , vol.67 , pp. 6092-6099
    • Gramantieri, L.1    Ferracin, M.2    Fornari, F.3
  • 12
    • 30644475098 scopus 로고    scopus 로고
    • MicroRNAs as oncogenes
    • DOI 10.1016/j.gde.2005.12.005, PII S0959437X05002182, Oncogenes and Cell Proliferation
    • Hammond SM. MicroRNAs as oncogenes. Curr Opin Genet Dev 2006;16:4-9. (Pubitemid 43089605)
    • (2006) Current Opinion in Genetics and Development , vol.16 , Issue.1 , pp. 4-9
    • Hammond, S.M.1
  • 13
    • 33749507943 scopus 로고    scopus 로고
    • A small piece in the cancer puzzle: MicroRNAs as tumor suppressors and oncogenes
    • DOI 10.1038/sj.onc.1209913, PII 1209913
    • Kent OA, Mendell JT. A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes. Oncogene 2006;25:6188-6196. (Pubitemid 44527849)
    • (2006) Oncogene , vol.25 , Issue.46 , pp. 6188-6196
    • Kent, O.A.1    Mendell, J.T.2
  • 14
    • 33846188098 scopus 로고    scopus 로고
    • MicroRNAs as oncogenes and tumor suppressors
    • DOI 10.1016/j.ydbio.2006.08.028, PII S0012160606010967
    • Zhang B, Pan X, Cobb GP, Anderson TA. microRNAs as oncogenes and tumor suppressors. Dev Biol 2007;302:1-12. (Pubitemid 46096921)
    • (2007) Developmental Biology , vol.302 , Issue.1 , pp. 1-12
    • Zhang, B.1    Pan, X.2    Cobb, G.P.3    Anderson, T.A.4
  • 15
    • 34247593034 scopus 로고    scopus 로고
    • Impaired microRNA processing enhances cellular transformation and tumorigenesis
    • DOI 10.1038/ng2003, PII NG2003
    • Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet 2007;39:673-677. (Pubitemid 46676103)
    • (2007) Nature Genetics , vol.39 , Issue.5 , pp. 673-677
    • Kumar, M.S.1    Lu, J.2    Mercer, K.L.3    Golub, T.R.4    Jacks, T.5
  • 16
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: From genes to environment
    • Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis: From genes to environment. Nat Rev Cancer 2006;6:674-687.
    • (2006) Nat Rev Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 17
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • DOI 10.1038/ng0802-339
    • Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002;31:339-346. (Pubitemid 35154440)
    • (2002) Nature Genetics , vol.31 , Issue.4 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 18
    • 9644254191 scopus 로고    scopus 로고
    • Application of comparative functional genomics to identify best-fit mouse model to study human cancer
    • Lee JS, Chu IS, Mikaelyan A, et al. Application of comparative functional genomics to identify best-fit mouse model to study human cancer. Nat Genet 2004;36:1306-1311.
    • (2004) Nat Genet , vol.36 , pp. 1306-1311
    • Lee, J.S.1    Chu, I.S.2    Mikaelyan, A.3
  • 19
    • 0033497604 scopus 로고    scopus 로고
    • Endogenous liver carcinogenesis in the rat
    • DOI 10.1046/j.1440-1827.1999.00990.x
    • Nakae D. Endogenous liver carcinogenesis in the rat. Pathol Int 1999;49:1028-1042. (Pubitemid 30193501)
    • (1999) Pathology International , vol.49 , Issue.12 , pp. 1028-1042
    • Nakae, D.1
  • 20
    • 30944456159 scopus 로고    scopus 로고
    • Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury
    • Powell CL, Kosyk O, Bradford BU, et al. Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury. Hepatology 2005;42:1137-1147.
    • (2005) Hepatology , vol.42 , pp. 1137-1147
    • Powell, C.L.1    Kosyk, O.2    Bradford, B.U.3
  • 21
    • 33749479908 scopus 로고    scopus 로고
    • Downregulation of miR-122 in the rodent and human hepatocellular carcinomas
    • Kutay H, Bai S, Datta J, et al. Downregulation of miR-122 in the rodent and human hepatocellular carcinomas. J Cell Biochem 2006;99:671-678.
    • (2006) J Cell Biochem , vol.99 , pp. 671-678
    • Kutay, H.1    Bai, S.2    Datta, J.3
  • 22
    • 0036668475 scopus 로고    scopus 로고
    • Cyclin G1 associates with MDM2 and regulates accumulation and degradation of p53 protein
    • Kimura SH, Nojima H. Cyclin G1 associates with MDM2 and regulates accumulation and degradation of p53 protein. Gen Cells 2002;7:869-880.
    • (2002) Gen Cells , vol.7 , pp. 869-880
    • Kimura, S.H.1    Nojima, H.2
  • 23
    • 34047210411 scopus 로고    scopus 로고
    • TP53 mutations and human hepatocellular carcinoma: Insights into the etiology and pathogenesis of liver cancer
    • Hussain SP, Schwank J, Staib F, Wang XW, Harris CC. TP53 mutations and human hepatocellular carcinoma: Insights into the etiology and pathogenesis of liver cancer. Oncogene 2007;26:2166-2176.
    • (2007) Oncogene , vol.26 , pp. 2166-2176
    • Hussain, S.P.1    Schwank, J.2    Staib, F.3    Wang, X.W.4    Harris, C.C.5
  • 24
    • 33947411861 scopus 로고    scopus 로고
    • Adventures in hepatocarcinogenesis
    • DOI 10.1146/annurev.pathol.2.010506.092027, Annual Review of Pathology: Mechanisms of Disease
    • Pitot HC. Adventures in hepatocarcinogenesis. Annu Rev Pathol 2007;2:1-29. (Pubitemid 46448058)
    • (2007) Annual Review of Pathology , vol.2 , pp. 1-29
    • Pitot, H.C.1
  • 27
    • 0031427093 scopus 로고    scopus 로고
    • Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats
    • DOI 10.1093/carcin/18.2.287
    • James SJ, Miller BJ, Basnakian AG, Pogribny IP, Pogribna M, Muskhelishvili L. Apoptosis and proliferation under conditions of deoxynucleotide pool dysbalance in liver of folate/methyl deficient rats. Carcinogenesis 1997;18:287-293. (Pubitemid 28132420)
    • (1997) Carcinogenesis , vol.18 , Issue.2 , pp. 287-293
    • James, S.J.1    Miller, B.J.2    Basnakian, A.G.3    Pogribny, I.P.4    Pogribna, M.5    Muskhelishvili, L.6
  • 28
    • 0031428480 scopus 로고    scopus 로고
    • Presence and consequence of uracil in preneoplastic DNA from folate/methyl-deficient rats
    • DOI 10.1093/carcin/18.11.2071
    • Pogribny IP, Muskhelishvili L, Miller BJ, James SJ. Presence and consequence of uracil in preneoplastic DNA from folate/methyl-deficient rats. Carcinogenesis 1997;18: 2071-2076. (Pubitemid 28134731)
    • (1997) Carcinogenesis , vol.18 , Issue.11 , pp. 2071-2076
    • Pogribny, I.P.1    Muskhelishvili, L.2    Miller, B.J.3    James, S.J.4
  • 29
    • 0348149136 scopus 로고    scopus 로고
    • Methyl deficiency causes reduction of the methyl-CpG-binding protein, MeCP2, in rat liver
    • DOI 10.1093/carcin/bgg163
    • Esfandiari F, Green R, Cotterman RF, Pogribny IP, James SJ, Miller JW. Methyl deficiency causes reduction of the methyl-CpG-binding protein, MeCP2, in rat liver. Carcinogenesis 2003;24:1935-1940. (Pubitemid 38008534)
    • (2003) Carcinogenesis , vol.24 , Issue.12 , pp. 1935-1940
    • Esfandiari, F.1    Green, R.2    Cotterman, R.F.3    Pogribny, I.P.4    James, S.J.5    Miller, J.W.6
  • 30
    • 0037058663 scopus 로고    scopus 로고
    • INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats
    • INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats. Cancer Lett 2002;187:69-75.
    • (2002) Cancer Lett , vol.187 , pp. 69-75
    • Pogribny, I.P.1    James, S.J.2
  • 31
    • 34249812122 scopus 로고    scopus 로고
    • MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
    • DOI 10.1038/sj.onc.1210293, PII 1210293
    • Welch C, Chen Y, Stallings RL. MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene 2007;26:5017-5022. (Pubitemid 47172643)
    • (2007) Oncogene , vol.26 , Issue.34 , pp. 5017-5022
    • Welch, C.1    Chen, Y.2    Stallings, R.L.3
  • 33
    • 39049191809 scopus 로고    scopus 로고
    • Exploration of human miRNA target genes in neuronal differentiation
    • Fukuda Y, Kawasaki H, Taira K. Exploration of human miRNA target genes in neuronal differentiation. Nucleic Acid Symp Ser 2005;49:341-342.
    • (2005) Nucleic Acid Symp Ser , vol.49 , pp. 341-342
    • Fukuda, Y.1    Kawasaki, H.2    Taira, K.3
  • 35
    • 33744805399 scopus 로고    scopus 로고
    • Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
    • Saito Y, Liang G, Egger G, et al. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 2006;9:435-443.
    • (2006) Cancer Cell , vol.9 , pp. 435-443
    • Saito, Y.1    Liang, G.2    Egger, G.3
  • 36
    • 33846190181 scopus 로고    scopus 로고
    • Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181
    • Pekarsky Y, Santanam U, Cimmino A, et al. Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. Cancer Res 2006;66:11590-11593.
    • (2006) Cancer Res , vol.66 , pp. 11590-11593
    • Pekarsky, Y.1    Santanam, U.2    Cimmino, A.3
  • 37
    • 34447527378 scopus 로고    scopus 로고
    • MiR-200b mediates post-transcriptional repression of ZFHX1B
    • DOI 10.1261/rna.586807
    • Christoffersen NR, Silahtaroglu A, Orom UA, Kauppinen S, Lund AH. miR-200b mediates post-transcriptional repression of ZFHX1B. RNA 2007;13:1172-1178. (Pubitemid 47080461)
    • (2007) RNA , vol.13 , Issue.8 , pp. 1172-1178
    • Christoffersen, N.R.1    Silahtaroglu, A.2    Orom, U.A.3    Kauppinen, S.4    Lund, A.H.5
  • 38
    • 20444479428 scopus 로고    scopus 로고
    • C-Myc-regulated microRNAs modulate E2F1 expression
    • DOI 10.1038/nature03677
    • O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT. c-Myc-regulated microRNAs modulate E2F1 expression. Nature 2005;435:839-843. (Pubitemid 40839736)
    • (2005) Nature , vol.435 , Issue.7043 , pp. 839-843
    • O'Donnell, K.A.1    Wentzel, E.A.2    Zeller, K.I.3    Dang, C.V.4    Mendell, J.T.5
  • 39
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer
    • DOI 10.1053/j.gastro.2007.05.022, PII S0016508507010025
    • Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007;133:647-658. (Pubitemid 47187346)
    • (2007) Gastroenterology , vol.133 , Issue.2 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Ghoshal, K.4    Jacob, S.T.5    Patel, T.6
  • 40
    • 41749113108 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    • Asangani IA, Rasheed SA, Nikolova DA, et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008;27:2128-2136.
    • (2008) Oncogene , vol.27 , pp. 2128-2136
    • Asangani, I.A.1    Rasheed, S.A.2    Nikolova, D.A.3
  • 41
    • 34548012848 scopus 로고    scopus 로고
    • The let-7 microRNA represses cell proliferation pathways in human cells
    • Johnson CD, Esquela-Kersher A, Stefani G, et al. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res 2007;67:7713-7722.
    • (2007) Cancer Res , vol.67 , pp. 7713-7722
    • Johnson, C.D.1    Esquela-Kersher, A.2    Stefani, G.3
  • 42
    • 30944437615 scopus 로고    scopus 로고
    • Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency
    • Pogribny IP, Ross SA, Wise C, et al. Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency. Mut Res 2006;593:80-87.
    • (2006) Mut Res , vol.593 , pp. 80-87
    • Pogribny, I.P.1    Ross, S.A.2    Wise, C.3
  • 43
    • 0031149098 scopus 로고    scopus 로고
    • Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat
    • DOI 10.1016/S0304-3835(97)04708-3, PII S0304383597047083
    • Pogribny IP, Miller BJ, James SJ. Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat. Cancer Lett 1997;115:31-38. (Pubitemid 27139853)
    • (1997) Cancer Letters , vol.115 , Issue.1 , pp. 31-38
    • Pogribny, I.P.1    Miller, B.J.2    James, S.J.3
  • 44
    • 34548565806 scopus 로고    scopus 로고
    • Overexpression of the MicroRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin
    • DOI 10.1158/0008-5472.CAN-07-1058
    • Hurteau GJ, Carlson JA, Spivack SD, Brock GJ. Overexpression of microRNA has-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin. Cancer Res 2007;67:7972-7976. (Pubitemid 47395127)
    • (2007) Cancer Research , vol.67 , Issue.17 , pp. 7972-7976
    • Hurteau, G.J.1    Carlson, J.A.2    Spivack, S.D.3    Brock, G.J.4
  • 45
    • 29144485712 scopus 로고    scopus 로고
    • SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions
    • Vanderwalle C, Comijin J, De Craene B, et al. SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions. Nucl Acid Res 2005;33:6566-6578.
    • (2005) Nucl Acid Res , vol.33 , pp. 6566-6578
    • Vanderwalle, C.1    Comijin, J.2    De Craene, B.3
  • 46
    • 34250851115 scopus 로고    scopus 로고
    • A microRNA component of the p53 tumour suppressor network
    • He L, He X, Lim LP, et al. A microRNA component of the p53 tumour suppressor network. Nature 2007;447:1130-1135.
    • (2007) Nature , vol.447 , pp. 1130-1135
    • He, L.1    He, X.2    Lim, L.P.3
  • 47
    • 35748961986 scopus 로고    scopus 로고
    • p53 enters the microRNA world
    • Hermeking H. p53 enters the microRNA world. Cancer Cell 2007;12:414-418.
    • (2007) Cancer Cell , vol.12 , pp. 414-418
    • Hermeking, H.1
  • 48
    • 0035936113 scopus 로고    scopus 로고
    • The E2F1-3 transcription factors are essential for cellular proliferation
    • Wu L, Timmers C, Maiti B, et al. The E2F1-3 transcription factors are essential for cellular proliferation. Nature 2001;414:457-462.
    • (2001) Nature , vol.414 , pp. 457-462
    • Wu, L.1    Timmers, C.2    Maiti, B.3
  • 50
    • 2942559162 scopus 로고    scopus 로고
    • E2F3-A novel repressor of the ARF/p53 pathway
    • DOI 10.1016/j.devcel.2004.05.012, PII S1534580704001741
    • Ginsberg D. E2F3 - A novel repressor of the ARF/p53 pathway. Dev Cell 2004;6:742-743. (Pubitemid 38745406)
    • (2004) Developmental Cell , vol.6 , Issue.6 , pp. 742-743
    • Ginsberg, D.1
  • 51
    • 31144465173 scopus 로고    scopus 로고
    • E2F3a stimulates proliferation, p53-independent apoptosis and carcinogenesis in a transgenic mouse model
    • Paulson QX, McArthur MJ, Johnson DG. E2F3a stimulates proliferation, p53-independent apoptosis and carcinogenesis in a transgenic mouse model. Cell Cycle 2006;5:184-190. (Pubitemid 43131157)
    • (2006) Cell Cycle , vol.5 , Issue.2 , pp. 184-190
    • Paulson, Q.X.1    McArthur, M.J.2    Johnson, D.G.3
  • 53
    • 10344247666 scopus 로고    scopus 로고
    • The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
    • DOI 10.1038/nature03147
    • Phan RT, Dalla-Favera R. The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature 2004;432:635-639. (Pubitemid 39626271)
    • (2004) Nature , vol.432 , Issue.7017 , pp. 635-639
    • Phan, R.T.1    Dalla-Favera, R.2
  • 54
    • 38949184246 scopus 로고    scopus 로고
    • Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival
    • Jiang J, Gusev Y, Aderca I, et al. Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival. Clin Cancer Res 2008;14:419-427.
    • (2008) Clin Cancer Res , vol.14 , pp. 419-427
    • Jiang, J.1    Gusev, Y.2    Aderca, I.3
  • 55
    • 40949087185 scopus 로고    scopus 로고
    • Identification of metastasis related microRNAs in hepatocellular carcinoma
    • Budhu A, Jia HL, Forgues M, et al. Identification of metastasis related microRNAs in hepatocellular carcinoma. Hepatology 2008;47:897-907.
    • (2008) Hepatology , vol.47 , pp. 897-907
    • Budhu, A.1    Jia, H.L.2    Forgues, M.3
  • 56
    • 0026523138 scopus 로고
    • The role of the stages on initiation and promotion in phenotypic diversity during hepatocarcinogenesis in the rat
    • Dragan YP, Pitot HC. The role of the stages on initiation and promotion in phenotypic diversity during hepatocarcinogenesis in the rat. Carcinogenesis 1992;13:739-750.
    • (1992) Carcinogenesis , vol.13 , pp. 739-750
    • Dragan, Y.P.1    Pitot, H.C.2


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