Backbone conformational flexibility of the lipid modified membrane anchor of the human N-Ras protein investigated by solid-state NMR and molecular dynamics simulation

Biochimica et Biophysica Acta - Biomembranes

Volumn 1798, Issue 2, 2010, Pages 275-285

  Vogel, Alexander ^a   Reuther, Guido ^b   Roark, Matthew B ^c   Tan, Kui Thong ^d   Waldmann, Herbert ^d   Feller, Scott E ^c   Huster, Daniel ^e  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c WABASH COLLEGE   (United States)

^d MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^e UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Lipid modification; Membrane protein; Order parameter; Relaxation; Replica exchange; Structural dynamics

Indexed keywords

CYSTEINE; DIMYRISTOYLPHOSPHATIDYLCHOLINE; MEMBRANE PROTEIN; METHIONINE; RAS PROTEIN;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CLUSTER ANALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HYDROPHOBICITY; MEMBRANE BINDING; MEMBRANE STRUCTURE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TERMINAL SEQUENCE;

COMPUTER SIMULATION; HUMANS; LIPIDS; MODELS, MOLECULAR; PEPTIDES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS P21(RAS); STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 74249084465     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2009.09.023     Document Type: Article

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