Selective Rac-1 inhibition protects from diabetes-induced vascular injury

Circulation Research

Volumn 98, Issue 2, 2006, Pages 218-225

  Vecchione, Carmine ^a   Aretini, Alessandra ^a   Marino, Gennaro ^a   Bettarini, Umberto ^a   Poulet, Roberta ^a   Maffei, Angelo ^a   Sbroggiò, Mauro ^b   Pastore, Lucio ^c   Gentile, Maria Teresa ^a   Notte, Antonella ^a   Iorio, Luca ^a   Hirsch, Emilio ^b   Tarone, Guido ^b   Lembo, Giuseppe ^a,d  

^a IRCCS NEUROMED   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Diabetes mellitus; Free radicals; Rac 1; Vessels

Indexed keywords

ADENOVIRUS VECTOR; GLUCOSE; GUANINE NUCLEOTIDE BINDING PROTEIN; MUTANT PROTEIN; RAC1 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; NEUROPEPTIDE; PROTEIN KINASE C; PROTEIN KINASE C BETA; RAC PROTEIN; RAC1 PROTEIN, HUMAN; RAC1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CYTOSOL; DIABETES MELLITUS; DIABETIC ANGIOPATHY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG ANTAGONISM; METABOLISM; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ANIMALS; CELLS, CULTURED; DIABETIC ANGIOPATHIES; ENDOTHELIUM, VASCULAR; GLUCOSE; HUMANS; MICE; MICE, INBRED C57BL; NADPH OXIDASE; NEUROPEPTIDES; OXIDATIVE STRESS; PROTEIN KINASE C; RAC GTP-BINDING PROTEINS; RAC1 GTP-BINDING PROTEIN;

EID: 33644853221     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000200440.18768.30     Document Type: Article

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