Blockade of dopamine, but not noradrenaline, transporters produces hyperthermia in rats that lack serotonin transporters

European Journal of Pharmacology

Volumn 629, Issue 1-3, 2010, Pages 7-11

  Olivier, Jocelien D A ^a   Cools, Alexander R ^a   Deen, Peter M T ^b   Olivier, Berend ^c,d   Ellenbroek, Bart A ^e  

^a RADBOUD UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Evotec ^*  (Germany)

Author keywords

Body temperature; DAT dopamine transporter ; Knockout rat; NET noradrenalin transporter ; Serotonin transporter; Stress induced hyperthermia

Indexed keywords

AMFEBUTAMONE; ATOMOXETINE; DOPAMINE TRANSPORTER; NORADRENALIN TRANSPORTER; SEROTONIN TRANSPORTER; VANOXERINE;

ADAPTATION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORE TEMPERATURE; DATA ANALYSIS; DOPAMINERGIC SYSTEM; DOSE TIME EFFECT RELATION; DRUG DOSE COMPARISON; DRUG MECHANISM; HYPERTHERMIA; MENTAL DISEASE; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; RAT; RAT STRAIN; RECEPTOR SENSITIVITY; SEROTONINERGIC SYSTEM; SEROTONINERGIC TRANSMISSION; STRESS;

ANIMALS; BODY TEMPERATURE; BUPROPION; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEVER; INJECTIONS; MALE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PIPERAZINES; PROPYLAMINES; RATS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS, PHYSIOLOGICAL;

EID: 74149090587     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.11.049     Document Type: Article

References (34)

1. Benloucif S., Keegan M.J., and Galloway M.P. Serotonin-facilitated dopamine release in vivo: pharmacological characterization. J. Pharmacol. Exp. Ther. 265 (1993) 373-377
2. Bouwknecht J.A., Hijzen T.H., van der Gugten J., Maes R.A., and Olivier B. Stress-induced hyperthermia in mice: effects of flesinoxan on heart rate and body temperature. Eur. J. Pharmacol. 400 (2000) 59-66
3. Conley R.K., and Hutson P.H. Effects of acute and chronic treatment with fluoxetine on stress-induced hyperthermia in telemetered rats and mice. Eur. J. Pharmacol. 564 (2007) 138-145
4. Cryan J.F., Harkin A., Naughton M., Kelly J.P., and Leonard B.E. Characterization of D-fenfluramine-induced hypothermia: evidence for multiple sites of action. Eur. J. Pharmacol. 390 (2000) 275-285
5. Delgado P.L., Charney D.S., Price L.H., Aghajanian G.K., Landis H., and Heninger G.R. Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch. Gen. Psychiatry 47 (1990) 411-418
6. Friedman B.H., and Thayer J.F. Autonomic balance revisited: panic anxiety and heart rate variability. J. Psychosom. Res. 44 (1998) 133-151
7. Guiard B.P., El M.M., Merali Z., and Blier P. Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions. Int. J. Neuropsychopharmacol. 11 (2008) 625-639
8. Holmes A., Murphy D.L., and Crawley J.N. Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. Biol. Psychiatry 54 (2003) 953-959
9. Homberg J.R., de Boer S.F., Raaso H.S., Olivier J.D., Verheul M., Ronken E., Cools A.R., Ellenbroek B.A., Schoffelmeer A.N., Vanderschuren L.J., De Vries T.J., and Cuppen E. Adaptations in pre- and postsynaptic 5-HT(1A) receptor function and cocaine supersensitivity in serotonin transporter knockout rats. Psychopharmacology (Berl) 200 (2008) 367-380
10. Homberg J.R., Olivier J.D., Smits B.M., Mul J.D., Mudde J., Verheul M., Nieuwenhuizen O.F., Cools A.R., Ronken E., Cremers T., Schoffelmeer A.N., Ellenbroek B.A., and Cuppen E. Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system. Neuroscience 146 (2007) 1662-1676
11. Iyer R.N., and Bradberry C.W. Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization. J. Pharmacol. Exp. Ther. 277 (1996) 40-47
12. Kalueff, A.V., Olivier, J.D., Nonkes, L.J., Homberg, J.R., 2010. Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes. Neuroscience & Biobehavioral Reviews 34 (3), 373-386.
13. Korsgaard S., Gerlach J., and Christensson E. Behavioral aspects of serotonin-dopamine interaction in the monkey. Eur. J. Pharmacol. 118 (1985) 245-252
14. 1A autoreceptor response and its evaluation as a model to selectively identify antidepressants. Br. J. Pharmacol. 107 (1992) 15-21
15. Moreno F.A., Rowe D.C., Kaiser B., Chase D., Michaels T., Gelernter J., and Delgado P.L. Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion. Mol. Psychiatry 7 (2002) 213-216
16. Murphy D.L., Lerner A., Rudnick G., and Lesch K.P. Serotonin transporter: gene, genetic disorders, and pharmacogenetics. Mol. Interv. 4 (2004) 109-123
17. Murphy D.L., and Lesch K.P. Targeting the murine serotonin transporter: insights into human neurobiology. Nat. Rev., Neurosci. 9 (2008) 85-96
18. Neumeister A., Konstantinidis A., Stastny J., Schwarz M.J., Vitouch O., Willeit M., Praschak-Rieder N., Zach J., de Z.M., Bondy B., Ackenheil M., and Kasper S. Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression. Arch. Gen. Psychiatry 59 (2002) 613-620
19. Neves G., Kliemann M., Betti A.H., Conrado D.J., Tasso L., Fraga C.A., Barreiro E.J., Teresa D.C., and Rates S.M. Serotonergic neurotransmission mediates hypothermia induced by the N-phenylpiperazine antipsychotic prototypes LASSBio-579 and LASSBio-581. Pharmacol. Biochem. Behav. 89 (2008) 23-30
20. Nijsen M.J., Croiset G., Diamant M., Broekhoven M.H., De Wied D., and Wiegant V.M. Vagal activation in novelty-induced tachycardia during the light phase in the rat. Physiol. Behav. 63 (1998) 233-239
21. 1B receptors for citalopram-induced hypothermia in the rat. Psychopharmacology (Berl) 154 (2001) 429-434
22. Olivier B., Zethof T., Pattij T., van B.M., van O.R., Leahy C., Oosting R., Bouwknecht A., Veening J., van der G.J., and Groenink L. Stress-induced hyperthermia and anxiety: pharmacological validation. Eur. J. Pharmacol. 463 (2003) 117-132
23. 1A receptor mediated. Eur. J. Pharmacol. 342 (1998) 177-182
24. Olivier J.D., Cools A.R., Olivier B., Homberg J.R., Cuppen E., and Ellenbroek B.A. Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats. Eur. J. Pharmacol. 590 (2008) 190-197
25. Olivier J.D., Van Der Hart M.G., Van Swelm R.P., Dederen P.J., Homberg J.R., Cremers T., Deen P.M., Cuppen E., Cools A.R., and Ellenbroek B.A. A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders. Neuroscience 152 (2008) 573-584
26. Olivier, J.D.A., Cools, A.R., Ellenbroek, B.A., Cuppen, E., Homberg, J.R., 2008c. The serotonin transporter knockout rat: a review. In: Experimental models in serotonin transporter research., in: Kaluev A (Ed.), Experimental models in serotonin transporter research. Nova Science Publishers, NY. In Press (chapter 6).
27. Pan Y., Gembom E., Peng W., Lesch K.P., Mossner R., and Simantov R. Plasticity in serotonin uptake in primary neuronal cultures of serotonin transporter knockout mice. Brain Res. Dev. Brain Res. 126 (2001) 125-129
28. Roche M., Harkin A., and Kelly J.P. Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomized rat. Neuropsychopharmacology 32 (2007) 1312-1320
29. Salomon L., Lanteri C., Glowinski J., and Tassin J.P. Behavioral sensitization to amphetamine results from an uncoupling between noradrenergic and serotonergic neurons. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 7476-7481
30. Sgoifo A., Stilli D., Medici D., Gallo P., Aimi B., and Musso E. Electrode positioning for reliable telemetry ECG recordings during social stress in unrestrained rats. Physiol. Behav. 60 (1996) 1397-1401
31. Smits B.M., Mudde J., Plasterk R.H., and Cuppen E. Target-selected mutagenesis of the rat. Genomics 83 (2004) 332-334
32. Smits B.M., Mudde J.B., van de Belt J., Verheul M., Olivier J., Homberg J., Guryev V., Cools A.R., Ellenbroek B.A., Plasterk R.H., and Cuppen E. Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis. Pharmacogenet.Genomics 16 (2006) 159-169
33. Stain-Malmgren R., Khoury A.E., berg-Wistedt A., and Tham A. Serotonergic function in major depression and effect of sertraline and paroxetine treatment. Int. Clin. Psychopharmacol. 16 (2001) 93-101
34. Zhou F.C., Lesch K., and Murphy D.L. Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative. Brain Res. 942 (2002) 109-119