Aberrant p16INK4a methylation is a frequent event in colorectal cancers: Prognostic value and relation to mRNA expression and immunoreactivity

Journal of Cancer Research and Clinical Oncology

Volumn 136, Issue 2, 2010, Pages 323-331

  Mitomi, Hiroyuki ^a   Fukui, Naoshi ^b   Tanaka, Nobuho ^b   Kanazawa, Hideki ^b   Saito, Tsuyoshi ^a   Matsuoka, Takashi ^a   Yao, Takashi ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION   (Japan)

Author keywords

Colorectal cancer; Methylation; P16INK4A; Prognosis

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; FLUOROURACIL; FOLINIC ACID; MESSENGER RNA; MITOMYCIN C;

ADULT; AGED; ARTICLE; CANCER RECURRENCE; CANCER SURVIVAL; CLINICAL FEATURE; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DNA DETERMINATION; FEMALE; GENE SILENCING; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; METHYLATION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ADJUVANT CHEMOTHERAPY; CANCER STAGING; COLORECTAL TUMOR; DNA METHYLATION; GENETICS; IMMUNOHISTOCHEMISTRY; METHODOLOGY; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOLOGY; POLYMERASE CHAIN REACTION; PREDICTION AND FORECASTING; PROMOTER REGION; RISK;

ADULT; AGED; AGED, 80 AND OVER; CHEMOTHERAPY, ADJUVANT; COLORECTAL NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE-FREE SURVIVAL; DNA METHYLATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM STAGING; ODDS RATIO; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 74049139131     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-009-0688-z     Document Type: Article

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