Enantiomeric determination of tramadol and O-desmethyltramadol in human plasma by fast liquid chromatographic technique coupled with mass spectrometric detection

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 3-4, 2010, Pages 481-486

  Chytil, Lukáš ^a   Matoušková, Olga ^a   Černá, Olga ^a   Pokorná, Pavla ^a   Vobruba, Václav ^a   Perlík, František ^a   Slanař, Ondřej ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Cytochrome P450 2D6; Enantiomeric separation; O Desmethyltramadol; Pharmacokinetics; Tramadol

Indexed keywords

ANALYTES; CHROMATOGRAPHIC TECHNIQUES; CONCENTRATION OF; CYTOCHROME P450; ENANTIOMERIC DETERMINATION; ENANTIOMERIC SEPARATION; HIGH CONCENTRATION; HUMAN PLASMAS; INTERNAL STANDARDS; INTRA-DAY ACCURACY; IONIZATION MASS SPECTROMETRY; ISOCRATIC ELUTION; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MASS SPECTROMETRIC DETECTION; MULTIPLE REACTION MONITORING; O-DESMETHYLTRAMADOL; SENSITIVE METHOD; SOLID-PHASE EXTRACTION; TRAMADOL; TRAMADOL HYDROCHLORIDE;

CELLULOSE; CHIRALITY; CHROMATOGRAPHIC ANALYSIS; DRUG PRODUCTS; ENANTIOMERS; EXTRACTION; IONIZATION OF LIQUIDS; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN); STANDARDS;

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

2 PROPANOL; CYTOCHROME P450 2D6; DIETHYLAMINE; HEXANE; O NORTRAMADOL; TRAMADOL;

ARTICLE; CALIBRATION; CHIRAL CHROMATOGRAPHY; DRUG BLOOD LEVEL; DRUG DETERMINATION; ENANTIOMER; FLOW RATE; HUMAN; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; SOLID PHASE EXTRACTION;

CALIBRATION; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 CYP2D6; HUMANS; LIMIT OF DETECTION; MASS SPECTROMETRY; PHENOTYPE; REPRODUCIBILITY OF RESULTS; SOLID PHASE EXTRACTION; STEREOISOMERISM; TIME FACTORS; TRAMADOL;

CELLULOSE; CHROMATOGRAPHY; EXTRACTION; IONIZATION; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; PLASMA; STANDARDS;

EID: 74049104150     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.12.005     Document Type: Article

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