Enantiomeric separation of tramadol and its active metabolite in human plasma by chiral high-performance liquid chromatography: Application to pharmacokinetic studies

Chirality

Volumn 11, Issue 4, 1999, Pages 272-279

  Campanero Martínez, D Miguel Angel ^a   Calahorra, B ^a   Valle, M ^b   Troconiz, I F ^c   Honorato, J ^a  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^c UNIVERSITY OF NAVARRA   (Spain)

Author keywords

(+)R,R O demethyl tramadol; (+)R,R tramadol; ( )S,S O demethyl tramadol in plasma; ( )S,S tramadol; Column liquid chromatography; Pharmacokinetics

Indexed keywords

KETAMINE; O DEMETHYLTRAMADOL; TRAMADOL; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; NORMAL HUMAN; PRIORITY JOURNAL;

ANALGESICS, OPIOID; BIOTRANSFORMATION; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; INDICATORS AND REAGENTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM; TRAMADOL;

EID: 0344780905     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1999)11:4<272::AID-CHIR3>3.0.CO;2-I     Document Type: Article

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