An atypical CNG channel activated by a single cGMP molecule controls sperm chemotaxis

Science Signaling

Volumn 2, Issue 94, 2009, Pages

  Bönigk, Wolfgang ^a,b   Loogen, Astrid ^a   Seifert, Reinhard ^a   Kashikar, Nachiket ^a,c   Klemm, Clementine ^d   Krause, Eberhard ^d   Hagen, Volker ^d   Kremmer, Elisabeth ^e   Strünker, Timo ^a,c   Kaupp, Benjamin ^a,c  

^a CENTER OF ADVANCED EUROPEAN STUDIES AND RESEARCH CAESAR   (Germany)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

^c MARINE BIOLOGICAL LABORATORY   (United States)

^d LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^e INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CHEMOATTRACTANT; CYCLIC GMP; CYCLIC NUCLEOTIDE GATED CHANNEL; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CALCIUM CELL LEVEL; CELL STRAIN HEK293; CHEMOTAXIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MUTAGENESIS; NUCLEOTIDE SEQUENCE; PHOTOLYSIS; PHYLOGENY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; SEQUENCE ANALYSIS; SPERM; ANIMAL; CHEMISTRY; CYTOLOGY; GENETICS; HYDROLYSIS; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR CLONING; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN PROCESSING; SEA URCHIN; SEQUENCE HOMOLOGY; SPERMATOZOON; WESTERN BLOTTING;

ARBACIA PUNCTULATA; ECHINOIDEA;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CHEMOTAXIS; CLONING, MOLECULAR; CYCLIC GMP; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; HYDROLYSIS; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR SEQUENCE DATA; PROTEIN PROCESSING, POST-TRANSLATIONAL; SEA URCHINS; SEQUENCE HOMOLOGY, AMINO ACID; SPERMATOZOA;

EID: 74049087172     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000516     Document Type: Article

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37. This work was supported by the German Research Foundation and the Fonds der Chemischen Industrie. We thank I. Weyand for providing testis mRNA, A. Franzen for technical assistance, P. Pelzer for electrophysiological support, and H. Krause for preparing the manuscript.