Nicotine reduces the incidence of type I diabetes in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 3, 2002, Pages 876-881

  Mabley, J G ^a   Pacher, P ^a   Southan, G J ^a   Salzman, A L ^a   Szabo C ^a  

^a INOTEK CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; GLUCOSE; INSULIN; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; NICOTINE; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH1 CELL; TH2 CELL;

AGE OF ONSET; ANIMALS; BLOOD GLUCOSE; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INSULIN; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; NICOTINE; NICOTINIC AGONISTS; NITRATES; NITRITES; PANCREAS;

EID: 0036179356     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.3.876     Document Type: Article

References (39)

1. Insulin-dependent diabetes mellitus as an autoimmune disease
2. Mechanisms of cyclosporine protection against spontaneous diabetes mellitus in the BB/W or rat
3. Troglitazone prevents insulin-dependent diabetes in the non-obese diabetic mouse
4. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
5. Immune factors in the pathogenesis of Insulin-dependent diabetes mellitus
6. Treatment with neutralizing antibodies specific for IL-1β prevents cyclophosphamide-induced diabetes in nonobese diabetic mice
7. IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function
8. Essential role for interferon-γ and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice
9. Nitric oxide production in islets from nonobese diabetic mice: Aminoguanidine-sensitive and -resistant stages in the immunological diabetic process
10. Effect of chronic nicotine administration on trinitrobenzene sulphonic acid-induced colitis
11. Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes
12. Suppression and acceleration of autoimmune diabetes by neutralization of endogenous interleukin-12 in NOD mice
13. Diabetic endothelial dysfunction: The role of poly(ADP-ribose) polymerase activation
14. Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-β, and prostaglandin E
15. The crucial role of IL-10 in the suppression of the immunological response in mice exposed to staphylococcal enterotoxin B
16. Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin
17. A transcriptional inhibitor of TNF-α prevents diabetes induced by multiple low-dose streptozotocin injections in mice
18. Characterization of noncholinergic nicotine receptors on human granulocytes
19. + T-cell responses
20. Transcription and translation of inducible nitric oxide synthase in pancreas of prediabetic BB rats
21. Spontaneous diabetes mellitus in the BB/W rat. Effects of glucocorticoids, cyclosporin A, and antiserum to rat lymphocytes
22. Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus
23. Nicotine protects mice from multiple low-dose streptozotocin induced diabetes
24. Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrene protects mice from multiple low-dose streptezotocin-induced diabetes
25. Nicotine inhibits the in vitro production of interleukin-2 and tumor necrosis factor-α by human mononuclear cells
26. Nicotinic receptors of rat lymphocytes during adjuvant polyarthritis
27. Effects of alcohol and nicotine on cytotoxic functions of human lymphocytes
28. Systemic delivery of interleukin-10 by intramuscular injection of expression plasmid DNA prevents autoimmune diabetes in nonobese diabetic mice
29. Immunology of IDDM
30. Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse
31. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation?
32. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus
33. Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus
34. An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitrite prevents diabetes development in nod mice
35. Nicotine inhibits the production of inflammatory mediators in U937 cells through modulation of nuclear factor-κB activation
36. Identification of nicotinic acetylcholine receptors on lymphocytes in the periphery as well as thymus in mice
37. Gmonomethyl-L-arginine on the onset of diabetes in the spontaneously diabetic BB rat
38. Effect of tumor necrosis factor-α on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetagenic process
39. The effect of nicotine on murine CD4 T cell responses