Fractalkine protein localization and gene expression in mouse brain

Journal of Neuroscience Research

Volumn 73, Issue 1, 2003, Pages 81-88

  Tarozzo, G ^a   Bortolazzi, S ^a   Crochemore, C ^a   Chen, S C ^b   Lira, A S ^b   Abrams, J S ^b   Beltramo, Massimiliano ^a,c  

^a Schering Plough Research Institute   (Italy)

^b MERCK RESEARCH LABORATORIES   (United States)

^c Schering Plough Research Institute   (Italy)

Author keywords

Chemokine; Gene expression; Immunocytochemistry

Indexed keywords

ANTIBODY; FRACTALKINE; MESSENGER RNA;

ANIMAL CELL; ARTICLE; BASAL GANGLION; BRAIN CORTEX; BRAIN STEM; BRAIN TISSUE; CELL INTERACTION; CELL LABELING; CONTROLLED STUDY; CORPUS STRIATUM; CYTOKINE PRODUCTION; FOREBRAIN; GENE EXPRESSION; GENETIC TRANSCRIPTION; HIPPOCAMPUS; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MOUSE; NEUROANATOMY; NEUROTRANSMISSION; NONHUMAN; NUCLEOTIDE SEQUENCE; OLFACTORY BULB; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PUTAMEN;

AMYGDALA; ANIMALS; ANIMALS, OUTBRED STRAINS; BASAL GANGLIA; BRAIN CHEMISTRY; CEREBRAL CORTEX; CHEMOKINES, CX3C; GENE EXPRESSION; HIPPOCAMPUS; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MEMBRANE PROTEINS; MICE; OLFACTORY BULB; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THALAMUS;

EID: 0038054080     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10645     Document Type: Article

References (16)

1. Bazan JF, Bacon KB, Hardiman G, Wang W, Soo K, Rossi D, Greaves DR, Zlotnik A, Schall TJ. 1997. A new class of membrane-bound chemokine with a CX3C motif. Nature. 385:640-644.
2. Chapman GA, Moores K, Harrison D, Campbell CA, Stewart BR, Strijbos PJ. 2000. Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage. J Neurosci 20:1-5.
3. Combadiere C, Salzwedel K, Smith ED, Tiffany HL, Berger EA, Murphy PM. 1998. Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1. J Biol Chem 273:23799-23804.
4. Cook DN, Chen SC, Sullivan LM, Manfra DJ, Wiekowski MT, Prosser DM, Vassileva G, Lira SA. 2001. Generation and analysis of mice lacking the chemokine fractalkine. Mol Cell Biol 21:3159-3165.
5. Harrison JK, Jiang Y, Chen S, Xia Y, Maciejewski D, McNamara PK, Streit WJ, Salafranca MN, Adhikari S, Thompson DA, Botti P, Bacon KB, Feng L. 1998. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proc Natl Acad Sci USA 95:10896-10901.
6. Harrison JK, Jiang Y, Wees EA, Salafranca MN, Liang HX, Feng L, Belardinelli L. 1999. Inflammatory agents regulate in vivo expression of fractalkine in endothelial cells of the rat heart. J Leukoc Biol 66:937-944.
7. Imai T, Hieshima K, Haskell C, Baba M, Nagira M, Nishimura M, Kakizaki M, Takagi S, Nomiyama H, Schall TJ, Yoshie O. 1997. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91:521-530.
8. Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, Sher A, Littman DR. 2000. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20:4106-4114.
9. Maciejewski-Lenoir D, Chen S, Feng L, Maki R, Bacon KB. 1999. Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia. J Immunol 163:1628-1635.
10. Meucci O, Fatatis A, Simen AA, Bushell TJ, Gray PW, Miller RJ. 1998. Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc Natl Acad Sci USA 95:14500-14505.
11. Nishiyori A, Minami M, Ohtani Y, Takami S, Yamamoto J, Kawaguchi N, Kume T, Akaike A, Satoh M. 1998. Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia? FEBS Lett 429:167-172.
12. Pan Y, Lloyd C, Zhou H, Dolich S, Deeds J, Gonzalo JA, Vath J, Gosselin M, Ma J, Dussault B, Woolf E, Alperin G, Culpepper J, Gutierrez-Ramos JC, Gearing D. 1997. Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature 387:611-617.
13. Schwaeble WJ, Stover CM, Schall TJ, Dairaghi DJ, Trinder PK, Linington C, Iglesias A, Schubart A, Lynch NJ, Weihe E, Schafer MK. 1998. Neuronal expression of fractalkine in the presence and absence of inflammation. FEBS Lett 439:203-207.
14. Soriano SG, Amaravadi LS, Wang YF, Zhou H, Yu GX, Tonra JR, Fairchild-Huntress V, Fang Q, Dunmore JH, Huszar D, Pan Y. 2002. Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury. J Neuroimmunol 125:59-65.
15. Tarozzo G, Campanella M, Ghiani M, Bulfone A, Beltramo M. 2002. Expression of fractalkine and its receptor, CX3CR1, in response to ischaemia-reperfusion brain injury in the rat. Eur J Neurosci 15:1663-1668.
16. Tong N, Perry SW, Zhang Q, James HJ, Guo H, Brooks A, Bal H, Kinnear SA, Fine S, Epstein LG, Dairaghi D, Schall TJ, Gendelman HE, Dewhurst S, Sharer LR, Gelbard HA. 2000. Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system. J Immunol 164:1333-1339.