Total synthesis, characterization, and conformational analysis of the naturally occurring hexadecapeptide integramide A and a diastereomer

Chemistry - A European Journal

Volumn 16, Issue 1, 2010, Pages 316-327

  De Zotti, Marta ^a   Damato, Francesca ^a   Formaggio, Fernando ^a   Crisma, Marco ^a   Schievano, Elisabetta ^a   Mammi, Stefano ^a   Kaptein, Bernard ^b   Broxterman, Quirinus B ^b   Felock, Peter J ^c,d   Hazuda, Daria J ^c,d   Singh, Sheo B ^c,d   Kirschbaum, Jochen ^a   Brückner, Hans ^a   Toniolo, Claudio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b DSM Pharmaceutical Products   (Netherlands)

^c MERCK RESEARCH LABORATORIES   (United States)

^d University of Giessen ^*

Author keywords

Circular dichroism; IR spectroscopy; NMR spectroscopy; Peptides; X ray diffraction

Indexed keywords

ABSOLUTE STEREOCHEMISTRY; AMINO ACID PEPTIDES; ANTI-HIV; C TERMINUS; CIRCULAR DICHROISM; CONFORMATIONAL ANALYSIS; CRYSTAL STATE; DIASTEREOMERS; DIPEPTIDE; FTIR ABSORPTION; HIV-1 INTEGRASE; IR SPECTROSCOPY; NATURAL COMPOUNDS; NATURALLY OCCURRING; NMR SPECTROSCOPY; NMR TECHNIQUES; TOTAL SYNTHESIS;

AMINO ACIDS; CIRCULAR DICHROISM SPECTROSCOPY; DICHROISM; DIFFRACTION; FOURIER TRANSFORM INFRARED SPECTROSCOPY; LIGHT; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC ACIDS; PEPTIDES; SPECTRUM ANALYSIS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL); VIRUSES; X RAY DIFFRACTION;

X RAY DIFFRACTION ANALYSIS;

DIPEPTIDE; INTEGRAMIDE A; INTEGRASE; INTEGRASE INHIBITOR; OLIGOPEPTIDE; PEPTIDE; PEPTIDE FRAGMENT;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; CONFORMATION; DRUG EFFECT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM; SYNTHESIS; X RAY DIFFRACTION;

AMINO ACID SEQUENCE; CIRCULAR DICHROISM; DIPEPTIDES; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PEPTIDES; STEREOISOMERISM; X-RAY DIFFRACTION;

EID: 73949097529     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200900945     Document Type: Article

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