Complete absolute configuration of integramide A, a natural, 16-mer peptide inhibitor of HIV-1 integrase, elucidated by total synthesis

ChemBioChem

Volumn 10, Issue 1, 2009, Pages 87-90

  De Zotti, Marta ^a   Formaggio, Fernando ^a   Kaptein, Bernand ^b   Broxterman, Quirinus B ^b   Felock, Peter J ^c   Hazuda, Daria J ^c   Singh, Sheo B ^c   Brückner, Hans ^d   Toniolo, Claudio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b DSM Pharmaceutical Products   (Netherlands)

^c MERCK RESEARCH LABORATORIES   (United States)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

HIV inhibitor; HPLC; NMR spectroscopy; Peptides; Stereochemistry elucidation

Indexed keywords

INTEGRAMIDE A; INTEGRASE INHIBITOR; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; INTEGRASE; OLIGOPEPTIDE; P31 INTEGRASE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

ARTICLE; CHIRAL CHROMATOGRAPHY; CONTROLLED STUDY; DIASTEREOISOMER; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; EPIMERIZATION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; MASS SPECTROMETRY; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEREOCHEMISTRY; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM; SYNTHESIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SEQUENCE; BIOLOGICAL PRODUCTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; STEREOISOMERISM;

EID: 59649126084     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200800443     Document Type: Article

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