Mitochondrial apoptosis and the peripheral benzodiazepine receptor: A novel target for viral and pharmacological manipulation

Journal of Experimental Medicine

Volumn 196, Issue 9, 2002, Pages 1121-1125

  Castedo, Maria ^a   Perfettini, Jean Luc ^a   Kroemer, Guido ^a,b  

^a CNRS   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4' CHLORODIAZEPAM; 6 [3 (1 ADAMANTYL) 4 HYDROXYPHENYL] 2 NAPHTHOIC ACID; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTIMYCIN A1; ATRACTYLOSIDE; BENZODIAZEPINE; BONGKREKIC ACID; CYCLOPHILIN; CYCLOSPORIN A; CYCLOSPORIN DERIVATIVE; CYTOKINE; DIAZEPAM BINDING INHIBITOR; GLUCOSE 6 PHOSPHATE; HEXOKINASE; ISOQUINOLINE DERIVATIVE; LONIDAMINE; M11L PROTEIN; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEINASE; PROTOPORPHYRIN; RASAGILINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; THROMBOCYTE ACTIVATING FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRULENCE FACTOR; VIRUS PROTEIN; VOLTAGE GATED CHANNEL FORMING PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; APOPTOSIS; CELL DEATH; CROSS LINKING; CYTOMEGALOVIRUS INFECTION; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; GENE OVEREXPRESSION; HEPATITIS B VIRUS; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MYXOMA VIRUS; NONHUMAN; NOTE; PRIORITY JOURNAL; VIRUS CELL INTERACTION; VIRUS REPLICATION; VIRUS VIRULENCE;

ANIMALS; APOPTOSIS; HUMANS; ION CHANNELS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYXOMA VIRUS; RECEPTORS, GABA-A; VIRAL PROTEINS;

EID: 0037020863     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021758     Document Type: Note

References (27)

1. Everett, H., M. Barry, X. Sun, S.F. Lee, C. Frantz, L.G. Berthiaume, G. McFadden, and R.C. Bleackley. 2002. The myxoma provirus protein, M11L, prevents apoptosis by direct interaction with the mitochondrial permeability transition pore. J. Exp. Med. 196:1127-1139.
2. Macen, J.L., K.A. Graham, S.F. Lee, M. Schreiber, L.K. Boshkov, and G. McFadden. 1996. Expression of the myxoma virus tumor necrosis factor receptor homologue and M11L genes is required to prevent virus-induced apoptosis in infected rabbit T lymphocytes. Virology. 218:232-237.
3. Everett, H., M. Barry, S.F. Lee, X. Sun, K. Graham, J. Stone, R.C. Bleackley, and G. McFadden. 2000. M11L: A novel mitochondria-localized protein of myxoma virus that blocks apoptosis of infected leukocytes. J. Exp. Med. 191:1487-1498.
4. Barrett, J.W., J.X. Cao, S. Hota-Mitchell, and G. McFadden. 2001. Immunomodulatory proteins of myxoma virus. Semin. Immunol. 13:73-84.
5. Guerin, J.L., J. Gelfi, S. Boullier, M. Delverdier, F.A. Bellanger, S. Bertagnoli, I. Drexler, G. Sutter, and F. Messud-Petit. 2002. Myxoma virus leukemia-associated protein is responsible for major histocompatibility complex class I and Fas-CD95 down-regulation and defines scrapins, a new group of surface cellular receptor abductor proteins. J. Virol. 76:2912-2923.
6. Zamzami, N., and G. Kroemer. 2001. Mitochondria in apoptosis. How Pandora's box opens. Nat. Rev. Mol. Cell Biol. 2:67-71.
7. Ravagnan, L., T. Roumier, and G. Kroemer. 2002. Mitochondria - The killer organelles and their weapons. J. Cell. Physiol. 192:131-137.
8. Patterson, S., C.S. Spahr, E. Daugas, S.A. Susin, T. Irinopoulos, C. Koehler, and G. Kroemer. 2000. Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition. Cell Death Differ. 7:137-144.
9. Van Loo, G., H. Demol, M. van Gurp, B. Hoorelbeke, P. Schotte, R. Beyaert, B. Zhivotovsky, K. Gevaert, W. Declercq, J. Vandekerckhove, and P. Vandenabeele. 2002. A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid. Cell Death Differ. 9:301-308.
10. Casellas, P., S. Galiegue, and A.S. Basile. 2002. Peripheral benzodiazepine receptors and mitochondrial function. Neurochem. Int. 40:475-486.
11. Decaudin, D., M. Castedo, A. Beurdeley-Thomas, F. Nemati, G. de Pinieux, A. Caron, P. Pouillart, J. Wijdenes, D. Rouillard, G. Kroemer, and M.-F. Poupon. 2002. Peripheral benzodiazepin receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo. Cancer Res. 62:1388-1393.
12. Youdim, M.B., and M. Weinstock. 2002. Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [N-propargul-(3R)aminoindan-5-YL)-ethyl methyl carbamate]. Cell. Mol. Neurobiol. 21:555-573
13. Parker, M.A., H.E. Bazan, V. Marcheselli, E.B. Rodriguez de Turco, and N.G. Bazan. 2002. Platelet-activating factor induces permeability transition and cytochrome c release in isolated brain mitochondria. J. Neurosci. Res. 69:39-50.
14. Verma, A., S.L. Facchina, D.J. Hirsch, S.-Y. Song, L.F. Dillahey, J.R. Williams, and S.H. Snyder. 1998. Photodynamic tumor therapy: Mitochondrial benzodiazepine receptors as a therapeutic target. Mol. Med. 4:40-45.
15. Boya, P., B. Roques, and G. Kroemer. 2001. Bacterial and viral proteins regulating apoptosis at the mitochondrial level. EMBO J. 20:4325-4331.
16. Waris, G., K.W. Huh, and A. Siddiqui. 2001. Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress. Mol. Cell. Biol. 21:7721-7730.
17. Goldmacher, V.S. 2002. vMIA, a viral inhibitor of apoptosis targeting mitochondria. Biochimie. 84:177-185.
18. Jacotot, E., K.F. Ferri, C. El Hamel, C. Brenner, S. Druillenec, J. Hoebeke, P. Rustin, D. Métivier, C. Lenoir, M. Geuskens, et al. 2001. Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 Vpr and Bcl-2. J. Exp. Med. 193:509-520.
19. Somasundaran, M., M. Sharkey, B. Brichacek, K. Luzuriaga, M. Emerman, J.L. Sullivan, and M. Stevenson. 2002. Evidence for a cytopathogenicity determinant in HIV-1 Vpr. Proc. Natl. Acad. Sci. USA. 99:9503-9508.
20. Zhang, L., Y. Huang, H. Yuan, S. Tuttleton, and D.D. Ho. 1997. Genetic characterization of vif, vpr, and vpu sequences from long-term survivors of human immunodeficiency virus type 1 infection. Virology. 228:340-349.
21. Costantini, P., E. Jacotot, D. Decaudin, and G. Kroemer. 2000. Mitochondrion as a novel target of anti-cancer chemotherapy. J. Natl. Cancer Inst. 92:1042-1053.
22. Banker, D.E., J.J. Cooper, D.A. Fennell, C.L. Willman, F.R. Appelbaum, and F.E. Cotter. 2002. PK11195, a peripheral benzodiazepine receptor ligand, chemosensitizes acute myeloid leukemia cells to relevant therapeutic agents by more than one mechanism. Leuk. Res. 26:91-106.
23. Miccoli, L., F. Poirson-Bichat, F. Sureau, R.B. Gonçalves, Y. Bourgeois, B. Dutrillaux, M.-F. Poupon, and S. Oudard. 1998. Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment. J. Natl. Cancer Inst. 90:1400-1406.
24. Baell, J., and D. Huang. 2002. Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs. Biochem. Pharmacol. 64:851-863.
25. Chen, M., D.J. Won, S. Krajewski, and R.A. Gottlieb. 2002. Calpain and mitochondria in ischemia/reperfusion injury. J. Biol. Chem. 277:29181-29186.
26. Waldmeier, P.C., J.J. Feldtrauer, T. Qian, and J.J. Lemasters. 2002. Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811. Mol. Pharmacol. 62:22-29.
27. Clarke, S.J., G.P. McStay, and A.P. Halestrap. 2002. Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from Cyclosporin A.J. Biol. Chem. 277:34793-34799.