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For example, in a crude untreated product of diethyl diallylmalonate RCM catalyzed by 5 mol % of Grubbs I-generation catalyst, the theoretical amount of Ru is 90 mg per 5 mg of product (18000 ppm). After filtration of the crude reaction mixture, the Ru level was reduced to 59.7 ±0.50 mg per 5 mg (12000 ppm). Further purification of such crude metathesis products usually reduces Ru levels below 2000 ppm, see ref. [3a] and (b) K. McEleney, D. P. Allen, A. E. Holliday, C. M. Crudden. Org. Lett. 8, 2663 (2006).
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(b) For example, in a crude untreated product of diethyl diallylmalonate RCM catalyzed by 5 mol % of Grubbs I-generation catalyst, the theoretical amount of Ru is 90 mg per 5 mg of product (18000 ppm). After filtration of the crude reaction mixture, the Ru level was reduced to 59.7 ±0.50 mg per 5 mg (12000 ppm). Further purification of such crude metathesis products usually reduces Ru levels below 2000 ppm, see ref. [3a] and (b) K. McEleney, D. P. Allen, A. E. Holliday, C. M. Crudden. Org. Lett. 8, 2663 (2006).
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Another solution to this problem might be based on the immobilization of a metathesis catalyst in a separate liquid or solid phase. For recent reviews, see: (a) A. H. Hoveyda, D. G. Gillingham, J. J. Van Veldhuizen, O. Kataoka, S. B. Garber, J. S. Kingsbury, J. P. A. Harrity. Org. Biomol. Chem. 2, 1 (2004);
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