Recognition specificity of neoglycopolymers prepared by ring-opening metathesis polymerization

Journal of the American Chemical Society

Volumn 118, Issue 9, 1996, Pages 2297-2298

  Mortell, Kathleen H ^a   Weatherman, Ross V ^a   Kiessling, Laura L ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE BINDING PROTEIN;

ARTICLE; CARBOHYDRATE SYNTHESIS; CELL ADHESION; POLYMERIZATION; PROTEIN BINDING;

EID: 0029870744     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja953574q     Document Type: Article

References (24)

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11. For alternative synthetic strategies to polyvalent carbohydrate-substituted materials, see: (a) Schnarr, R. L.; Weigel, P. H.; Kuhlenschmidt, M. S.; Lee, Y. C.. Roseman, S. J. Biol. Chem. 1979, 253, 7940-51. (b) Kingery-Wood. J. E.; Williams, K. W.; Sigal. G. B., Whitesides, G. M. J. Am. Chem. Soc. 1992, 114, 7303-5. (c) Roy, R.; Zanini. D.; Meunier, S. J.; Romanowska. A. J. Chem. Soc.. Chem. Commun. 1993, 1869-72. (d) Spevak, W.; Nasy, J. O.; Charych, D. H.; Schaefer, M. E.; Gilbert, J. H.; Bednarski, M. D. J. Am. Chem. Soc. 1993, 115, 1146-7. (e) Kiessling, L. L.; Pohl, N. L. Chem. Biol. 1996, 3, 71-77 and references cited therein.
12. For alternative synthetic strategies to polyvalent carbohydrate-substituted materials, see: (a) Schnarr, R. L.; Weigel, P. H.; Kuhlenschmidt, M. S.; Lee, Y. C.. Roseman, S. J. Biol. Chem. 1979, 253, 7940-51. (b) Kingery-Wood. J. E.; Williams, K. W.; Sigal. G. B., Whitesides, G. M. J. Am. Chem. Soc. 1992, 114, 7303-5. (c) Roy, R.; Zanini. D.; Meunier, S. J.; Romanowska. A. J. Chem. Soc.. Chem. Commun. 1993, 1869-72. (d) Spevak, W.; Nasy, J. O.; Charych, D. H.; Schaefer, M. E.; Gilbert, J. H.; Bednarski, M. D. J. Am. Chem. Soc. 1993, 115, 1146-7. (e) Kiessling, L. L.; Pohl, N. L. Chem. Biol. 1996, 3, 71-77 and references cited therein.
13. For alternative synthetic strategies to polyvalent carbohydrate-substituted materials, see: (a) Schnarr, R. L.; Weigel, P. H.; Kuhlenschmidt, M. S.; Lee, Y. C.. Roseman, S. J. Biol. Chem. 1979, 253, 7940-51. (b) Kingery-Wood. J. E.; Williams, K. W.; Sigal. G. B., Whitesides, G. M. J. Am. Chem. Soc. 1992, 114, 7303-5. (c) Roy, R.; Zanini. D.; Meunier, S. J.; Romanowska. A. J. Chem. Soc.. Chem. Commun. 1993, 1869-72. (d) Spevak, W.; Nasy, J. O.; Charych, D. H.; Schaefer, M. E.; Gilbert, J. H.; Bednarski, M. D. J. Am. Chem. Soc. 1993, 115, 1146-7. (e) Kiessling, L. L.; Pohl, N. L. Chem. Biol. 1996, 3, 71-77 and references cited therein.
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21. For experimental details, see the supporting information.
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23. These improvements in efficacy result from the multivalent presentation of the ligands and are not a nonspecific effect of the polymer chain. A structurally related neoglycopolymer bearing a sugar not bound by concanavalin A. fucose. did not inhibit agglutination, ref 6.
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