Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model

Neurotoxicology and Teratology

Volumn 32, Issue 1, 2010, Pages 42-51

  Slotkin, Theodore A ^a   Seidler, Frederic J ^a   Fumagalli, Fabio ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Brain derived neurotrophic factor; Diazinon; Dieldrin; Fibroblast growth factor; fzd gene family; Metal neurotoxicity; Microarrays; Nerve growth factor; Neuronal development; Neurotoxicity; Neurotrophic factors; Nickel; Organochlorine insecticides; Organophosphate insecticides; PC12 cells; Tyrosine kinase receptors; wnt gene family

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; DIELDRIN; DIMPYLATE; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; FRIZZLED PROTEIN; MESSENGER RNA; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIC FACTOR; NEUROTROPHIN; NEUROTROPHIN RECEPTOR; NICKEL; ORGANOCHLORINE PESTICIDE; ORGANOPHOSPHATE PESTICIDE; WNT PROTEIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL STRAIN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; EXPERIMENTAL MODEL; GENETIC TRANSCRIPTION; IN VITRO STUDY; MICROARRAY ANALYSIS; MULTIGENE FAMILY; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RISK ASSESSMENT; SCREENING TEST;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DIAZINON; DIELDRIN; FIBROBLAST GROWTH FACTORS; FRIZZLED RECEPTORS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INSECTICIDES; NERVE GROWTH FACTOR; NEURONS; NICKEL; PC12 CELLS; RATS; TRACE ELEMENTS; WNT PROTEINS;

EID: 73649136527     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ntt.2008.11.006     Document Type: Article

References (62)

1. Aldridge J.E., Meyer A., Seidler F.J., and Slotkin T.A. Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. Toxicology and Applied Pharmacology 203 (2005) 134-144
2. Bagchi D., Bagchi M., Hassoun E.A., and Stohs S.J. In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides. Toxicology 104 (1995) 129-140
3. Bagchi D., Bhattacharya G., and Stohs S.J. In vitro and in vivo induction of heat shock (stress) protein (Hsp) gene expression by selected pesticides. Toxicology 112 (1996) 57-68
4. Barone S., Das K.P., Lassiter T.L., and White L.D. Vulnerable processes of nervous system development: a review of markers and methods. Neurotoxicology 21 (2000) 15-36
5. Betancourt A.M., Burgess S.C., and Carr R.L. Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain. Toxicological Sciences 92 (2006) 500-506
6. Betancourt A.M., Filipov N.M., and Carr R.L. Alteration of neurotrophins in the hippocampus and cerebral cortex of young rats exposed to chlorpyrifos and methyl parathion. Toxicological Sciences 100 (2007) 445-455
7. Blak A.A., Naserke T., Weisenhorn D.M.V., Prakash N., Partanen J., and Wurst W. Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse. Development Dynamics 233 (2005) 1023-1030
8. Boyes W.K. Neurotoxicology and behavior. In: Bingham E., Cohrseen B., and Powell C.H. (Eds). Patty's Toxicology. Fifth Edition (2001), John Wiley & Sons, New York 55-121
9. Conner J.M., and Varon S. Developmental profile of NGF immunoreactivity in the rat brain: a possible role of NGF in the establishment of cholinergic terminal fields in the hippocampus and cortex. Developmental Brain Research 101 (1997) 67-79
10. Costa L.G. Neurotoxicity testing: a discussion of in vitro alternatives. Environmental Health Perspectives 106 Suppl. 2 (1998) 505-510
11. Crumpton T.L., Seidler F.J., and Slotkin T.A. Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factor involved in cell replication and differentiation. Brain Research 857 (2000) 87-98
12. Crumpton T.L., Seidler F.J., and Slotkin T.A. Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?. Developmental Brain Research 121 (2000) 189-195
13. Das K.P., and Barone S. Neuronal differentiation in PC12 cells is inhibited by chlorpyrifos and its metabolites: is acetylcholinesterase inhibition the site of action?. Toxicology and Applied Pharmacology 160 (1999) 217-230
14. Dono R. Fibroblast growth factors as regulators of central nervous system development and function. American Journal of Physiology - Heart & Circulatory Physiology 284 (2003) R867-R881
15. Dreyfus C.F. Neurotransmitters and neurotrophins collaborate to influence brain development. Perspectives on developmental neurobiology 5 (1998) 389-399
16. Eriksson P. Developmental neurotoxicity of environmental agents in the neonate. Neurotoxicology 18 (1997) 719-726
17. Flaskos J., McLean W.G., and Hargreaves A.J. The toxicity of organophosphate compounds towards cultured PC12 cells. Toxicology Letters 70 (1994) 71-76
18. Fujita K., Lazarovici P., and Guroff G. Regulation of the differentiation of PC12 pheochromocytoma cells. Environmental Health Perspectives 80 (1989) 127-142
19. Glinka A., Wu W., Delius H., Monaghan A.P., Blumenstock C., and Niehrs C. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391 (1998) 357-362
20. Grandjean P., and Landrigan P.J. Developmental neurotoxicity of industrial chemicals. Lancet 368 (2006) 2167-2178
21. Gunhaga L., Marklund M., Sjodal M., Hsieh J.C., Jessell T.M., and Edlund T. Specification of dorsal telencephalic character by sequential Wnt and FGF signaling. Nature Neuroscience 6 (2003) 701-707
22. Henderson C.E. Role of neurotrophic factors in neuronal development. Current opinion in neurobiology 6 (1996) 64-70
23. Jameson R.R., Seidler F.J., Qiao D., and Slotkin T.A. Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells. Environmental Health Perspectives 114 (2006) 667-672
24. Jameson R.R., Seidler F.J., and Slotkin T.A. Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon and diazinon. Environmental Health Perspectives 115 (2007) 65-70
25. Levin E.D., Addy N., Christopher N.C., Seidler F.J., and Slotkin T.A. Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Developmental Brain Research 130 (2001) 83-89
26. Li W.W., and Casida J.E. Organophosphorus neuropathy target esterase inhibitors selectively block outgrowth of neurite-like and cell processes in cultured cells. Toxicology Letters 98 (1998) 139-146
27. Li F., Chong Z.Z., and Maiese K. Vital elements of the Wnt-Frizzled signaling pathway in the nervous system. Currency Neurovasc Research 2 (2005) 331-340
28. Meyer A., Seidler F.J., Aldridge J.E., Tate C.A., Cousins M.M., and Slotkin T.A. Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure. Environmental Health Perspectives 112 (2004) 295-301
29. Meyer A., Seidler F.J., Aldridge J.E., and Slotkin T.A. Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide, chlorpyrifos. Toxicology and Applied Pharmacology 203 (2005) 154-166
30. Monnet-Tschudi F., Zurich M.G., and Honegger P. Neurotoxicant-induced inflammatory response in three-dimensional brain cell cultures. Human and Experimental Toxicology 26 (2007) 339-346
31. Nagata K., Huang C.S., Song J.H., and Narahashi T. Direct actions of anticholinesterases on the neuronal nicotinic acetylcholine receptor channels. Brain Res 769 (1997) 211-218
32. Ostrea E.M., Morales V., Ngoumgna E., Prescilla R., Tan E., Hernandez E., Ramirez G.B., Cifra H.L., and Manlapaz M.L. Prevalence of fetal exposure to environmental toxins as determined by meconium analysis. Neurotoxicology 23 (2002) 329-339
33. Qiao D., Seidler F.J., and Slotkin T.A. Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells. Environmental Health Perspectives 109 (2001) 909-913
34. Qiao D., Seidler F.J., Violin J.D., and Slotkin T.A. Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos. Developmental Brain Research 147 (2003) 183-190
35. Qiao D., Seidler F.J., and Slotkin T.A. Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. Toxicology and Applied Pharmacology 206 (2005) 17-26
36. Reichardt L.F. Neurotrophin-regulated signalling pathways. Phil Transaction Royal Society of London B 361 (2006) 1545-1564
37. Saarimaki-Vire J., Peltopuro P., Lahti L., Naserke T., Blak A.A., Vogt Weisenhorn D.M., Yu K., Ornitz D.M., Wurst W., and Partanen J. Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain. Journal of Neuroscience 27 (2007) 8581-8592
38. Shimogori T., Banuchi V., Ng H.Y., Strauss J.B., and Grove E.A. Embryonic signaling centers expressing BMP, WNT and FGF proteins interact to pattern the cerebral cortex. Development 131 (2004) 5639-5647
39. Shimogori T., VanSant J., Paik E., and Grove E.A. Members of the Wnt, Fz, and Frp gene families expressed in postnatal mouse cerebral cortex. Journal of comparative neurology 473 (2004) 496-510
40. Slikker W., Xu Z.A., Levin E.D., and Slotkin T.A. Mode of action: disruption of brain cell replication, second messenger, and neurotransmitter systems during development leading to cognitive dysfunction - developmental neurotoxicity of nicotine. Critical Reviews in Toxicology 35 (2005) 703-711
41. Slotkin T.A. Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicology and Applied Pharmacology 198 (2004) 132-151
42. Slotkin T.A. Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: a personal view from an academic perspective. Neurotoxicology 25 (2004) 631-640
43. Slotkin T.A. Developmental neurotoxicity of organophosphates: a case study of chlorpyrifos. In: Gupta R.C. (Ed). Toxicity of Organophosphate and Carbamate Pesticides (2005), Elsevier Academic Press, San Diego 293-314
44. Slotkin T.A., and Seidler F.J. Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems. Brain Research Bulletin 72 (2007) 232-274
45. Slotkin T.A., Cousins M.M., Tate C.A., and Seidler F.J. Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. Brain Res 902 (2001) 229-243
46. Slotkin T.A., Auman J.T., and Seidler F.J. Ontogenesis of β-adrenoceptor signaling: implications for perinatal physiology and for fetal effects of tocolytic drugs. Journal of Pharmacology and Experimental Therapeutics 306 (2003) 1-7
47. Slotkin T.A., Levin E.D., and Seidler F.J. Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Environmental Health Perspectives 114 (2006) 746-751
48. Slotkin T.A., MacKillop E.A., Ryde I.T., and Seidler F.J. Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells. Environmental Health Perspectives 115 (2007) 1306-1313
49. Slotkin T.A., MacKillop E.A., Ryde I.T., Tate C.A., and Seidler F.J. Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine and divalent nickel. Environmental Health Perspectives 115 (2007) 93-101
50. Slotkin T.A., Seidler F.J., and Fumagalli F. Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily. Environmental Health Perspectives 115 (2007) 909-916
51. Slotkin T.A., Bodwell B.E., Levin E.D., and Seidler F.J. Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems. Environmental Health Perspectives 116 (2008) 340-348
52. Slotkin T.A., Seidler F.J., and Fumagalli F. Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro. Brain Research Bulletin 76 (2008) 424-438
53. Song X., Violin J.D., Seidler F.J., and Slotkin T.A. Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells. Toxicology and Applied Pharmacology 151 (1998) 182-191
54. Sutton L.P., Honardoust D., Mouyal J., Rajakumar N., and Rushlow W.J. Activation of the canonical Wnt pathway by the antipsychotics haloperidol and clozapine involves dishevelled-3. Journal of Neurochemistry 102 (2007) 153-169
55. Szpir M. Tracing the origins of autism: a spectrum of new studies. Environmental Health Perspectives 114 (2006) A412-A417
56. Teng K.K., and Greene L.A. Cultured PC12 cells: a model for neuronal function and differentiation. In: Celis J.E. (Ed). Cell Biology: A Laboratory Handbook (1994), Academic Press, San Diego 218-224
57. Timofeeva O.A., Roegge C.S., Seidler F.J., Slotkin T.A., and Levin E.D. Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon. Neurotoxicology and Teratology 30 (2008) 38-45
58. Tuler S.M., Hazen A.A., and Bowen J.M. Release and metabolism of dopamine in a clonal line of pheochromocytoma (PC12) cells exposed to fenthion. Fund Applied Toxicol 13 (1989) 484-492
59. Weiss B., Amler S., and Amler R.W. Pesticides. Pediatrics 113 (2004) 1030-1036
60. Yanai J., Vatury O., and Slotkin T.A. Cell signaling as a target and underlying mechanism for neurobehavioral teratogenesis. Annals of the New York Academy of Sciences 965 (2002) 473-478
61. Yanai J., Beer A., Huleihel R., Izrael M., Katz S., Levi Y., Rozenboim I., Yaniv S.P., and Slotkin T.A. Convergent effects on cell signaling mechanisms mediate the actions of different neurobehavioral teratogens: alterations in cholinergic regulation of PKC in chick and avian models. Annals of the New York Academy of Sciences 1025 (2004) 595-601
62. Zhou C.J., Borello U., Rubenstein J.L., and Pleasure S.J. Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway. Neuroscience 142 (2006) 1119-11311