Neurotoxicity testing: A discussion of in vitro alternatives

Environmental Health Perspectives

Volumn 106, Issue SUPPL. 2, 1998, Pages 505-510

  Costa, Lucio G ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b IRCCS   (Italy)

Author keywords

In vitro testing; Neurotoxicity

Indexed keywords

CONFERENCE PAPER; IN VITRO STUDY; NEUROTOXICITY; NEUROTOXICOLOGY; PRIORITY JOURNAL; TOXICITY TESTING;

ANIMALIA;

EID: 0031859987     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.98106505     Document Type: Conference Paper

References (30)

1. Office of Technology Assessment. Neurotoxicity:Identifying and Controlling Poisons of the Nervous System. U.S. Congress, 1990.
2. National Research Council. Environmental Neurotoxicology. Washington: National Academy Press, 1992.
3. Ladefoged O, Lam HR, Ostergaard G, Nielsen E, Arlien Soborg P. Neurotoxicology:Review of Definitions, Methodology and Criteria. Copenhagen:anish Environmental Protection Agency, 1995.
4. ECETOC. Evaluation of the Neurotoxic Potential of Chemicals. Brussels: European Center for Ecotoxicology and Toxicology of Chemicals, 1992.
5. Costa LG. Effects of neurotoxicants on brain neurochemistry. In:Neurotoxicology (Tilson H, Mitchell C, eds). New York:Raven Press, 1992;101-123.
6. Eisenbrandt DL, Nitschke KD. Inhalation toxicity of sulfurvl fluoride in rats and rabbits. Fundam Appl Toxicol 12:540-548 (1989).
7. Mathews HB, Dixon D, Herr DW, Tilson H. Subchronic toxicity studies indicate that tris (2-chlorocthyl) phosphate administration results in lesions in the rat hippocampus. Toxicol Ind Health 6:1-10 (1990).
8. Kluwe WM, Montgomery CA, Giles HD, Prejean JD. Encephalopathy in rats and nephropathy in rats and mice after subchronic oral exposure to benzaldehyde. Food Chem Toxicol 21:245-254 (1983).
9. USEPA. Pesticide Assessment Guidelines, Subdivision F. Hazard Evaluation:Human and Domestic Animals. Addendum 10:Neurotoxicity Series 81, 82, and 83. Washington:.S. Environmental Protection Agency, 1991.
10. OECD. Draft Guidelines for Testing Chemicals:Neurotoxicity Test Battery, 1992. Brussels: Organisation for Economic Cooperation and Development, 1992.
11. Veronesi B. The use of cell culture for evaluating neurotoxicity. In:Neurotoxicology (Tilson H, Mitchell C, eds). New York:Raven Press, 1992;21-49.
12. Roush W. Hunting for animal alternatives. Science 274:168-171 (1996).
13. Veronesi B. In vitro screening batteries for neurotoxicants. Neurotoxicology 13:185-196 (1922).
14. Walum E, Nordin M, Beckman M, Odland L. Cellular methods for identification of neurotoxic chemicals and estimation of neurotoxicological risk, Toxicol in Vitro 7:321-326 (1993).
15. Abdulla EM, Campbell IC. In vitro tests of neurotoxicity. J Pharmacol Toxicol Meth 29:69-75 (1993).
16. Abdulla EM, Campbell IC. Studies of neurotoxicity in cellular models. In:In Vitro Methods in Pharmaceutical Research. San Diego, CA: Academic Press, 1997;155-180.
17. Campbell IC, Fletcher L, Grant PAA, Abdulla EM. Validation of in vitro tests in neurotoxicology. ATLA 24:339-347 (1993).
18. Atterwill CK, Davenport-Jones J, Goonetilleke S, Johnston H, Purcell W, Thomas SM, West M, Williams S. New models for the in vitro assessment of neurotoxicity in the nervous system and the preliminary validation stages of a tiered test model. Toxicol In Vitro 7:569-580 (1993).
19. USEPA. Proposed guidelines for neurotoxicity risk assessment. Fed Reg 60(192):52032-52056 (1995).
20. Janigro D, Costa LG. Effects of trimethyltin on granule cells excitability in the in vitro rat dentate gyrus. Neurotoxicol Teratol 9:33-38 (1987).
21. Atterwill CK. Brain reaggregate cultures in neurotoxicological investigations:adaptational and neuroregenerative processes following lesions. Mol Toxicol 1:489-502 (1987).
22. Stanness KA, Guatteo E, Janigro D. A dynamic model of the blood brain barrier in vitro. Neurotoxicology 17:481-496 (1996).
23. Veronesi B. Characterization of the MDCK cell line for screening neurotoxicants. Neurotoxicology 17:433-444 (1996).
24. Walum E, Odland L, Romert L, Ekblad-Sekund G, Nilsson M, Calleman CJ, Bergmark E, Costa LG. Biochemical approaches to neurotoxicology in vitro:attempts to develop a test system for chemically induced axonopathy. In:In Vitro Methods in Toxicology. London: Academic Press, 1992;237-251.
25. Walum E, Hanson E, Harvey AL. In vitro testing of neurotoxicity. ATLA 18:153-179 (1990).
26. Atterwill CK, Simpson MG, Evans RJ, Allen SL, Ray D. Alternative methods and their application in neurotoxicity testing. In:Animals and Alternatives in Toxicology (Balls M. Bridges J, Southee J, eds). London: MacMillan, 1991; 121-152.
27. Dewar AJ. Neurotoxicity. In:Animals and Alternatives in Toxicity Testing (Balls M, Riddell RJ, Worden AN, eds). London: Academic Press, 1983;230-284).
28. Correll L, Ehrich M. A microassay method for neurotoxic esterase determination. Fundam Appl Toxicol 11:110-116 (191).
29. O'Callaghan JP. Assessment of neurotoxicity using assays of neuron- and glia-localized proteins:chronology and critique. In:Neurotoxicology (Tilson H, Mitchell C, eds). New York:Raven Press, 1992;83-100.
30. Goldey ES, Tilson HA, Crofton KM. Implications of the use of neonatal birth weight, growth, viability, and survival data for predicting developmental neurotoxicity:a review of the literature. Neurotoxicol Teratol 17:313-332 (1995).