메뉴 건너뛰기




Volumn 37, Issue 1, 2010, Pages 115-120

Multidrug resistance-associated proteins and implications in drug development

Author keywords

Drug development; Drug transport; Multidrug resistance associated proteins; Pharmacokinetics; Toxicity

Indexed keywords

ANTHRACYCLINE DERIVATIVE; ANTIANDROGEN; BERBERINE; BILE ACID; BILIRUBIN GLUCURONIDE; CIPROFLOXACIN; COLCHICINE; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); DACTINOMYCIN; DIFLOXACIN; EPIPODOPHYLLOTOXIN; EPOTHILONE DERIVATIVE; GLUCURONIC ACID; GLUTATHIONE; GREPAFLOXACIN; INDINAVIR; LEUKOTRIENE C4; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; MULTIDRUG RESISTANCE PROTEIN 6; PIRARUBICIN; RITONAVIR; SAQUINAVIR; TAXANE DERIVATIVE; UNINDEXED DRUG; VINCA ALKALOID;

EID: 73649120349     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2009.05252.x     Document Type: Conference Paper
Times cited : (45)

References (38)
  • 1
    • 68949192657 scopus 로고    scopus 로고
    • Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior
    • Stanley LA, Horsburgh BC, Ross J, Scheer N, Wolf CR. Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior. Drug Metab. Rev. 2009 41 : 27 65.
    • (2009) Drug Metab. Rev. , vol.41 , pp. 27-65
    • Stanley, L.A.1    Horsburgh, B.C.2    Ross, J.3    Scheer, N.4    Wolf, C.R.5
  • 2
    • 48749108121 scopus 로고    scopus 로고
    • MRP class of human ATP binding cassette (ABC) transporters: Historical background and new research directions
    • Toyoda Y, Hagiya Y, Adachi T, Hoshijima K, Kuo MT, Ishikawa T. MRP class of human ATP binding cassette (ABC) transporters: Historical background and new research directions. Xenobiotica 2008 38 : 833 862.
    • (2008) Xenobiotica , vol.38 , pp. 833-862
    • Toyoda, Y.1    Hagiya, Y.2    Adachi, T.3    Hoshijima, K.4    Kuo, M.T.5    Ishikawa, T.6
  • 3
    • 0036074018 scopus 로고    scopus 로고
    • Mammalian ABC transporters in health and disease
    • Borst P, Elferink RO. Mammalian ABC transporters in health and disease. Annu. Rev. Biochem. 2002 71 : 537 592.
    • (2002) Annu. Rev. Biochem. , vol.71 , pp. 537-592
    • Borst, P.1    Elferink, R.O.2
  • 4
    • 53349117254 scopus 로고    scopus 로고
    • Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development
    • Zhou SF, Wang LL, Di YM et al. Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development. Curr. Med. Chem. 2008 15 : 1981 2039.
    • (2008) Curr. Med. Chem. , vol.15 , pp. 1981-2039
    • Zhou, S.F.1    Wang, L.L.2    Di, Y.M.3
  • 5
    • 0035958862 scopus 로고    scopus 로고
    • Transport of the β-O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog
    • Leslie EM, Ito K, Upadhyaya P, Hecht SS, Deeley RG, Cole SP. Transport of the β-O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog. J. Biol. Chem. 2001 276 : 27846 27854.
    • (2001) J. Biol. Chem. , vol.276 , pp. 27846-27854
    • Leslie, E.M.1    Ito, K.2    Upadhyaya, P.3    Hecht, S.S.4    Deeley, R.G.5    Cole, S.P.6
  • 6
    • 34347230130 scopus 로고    scopus 로고
    • Glutathione export during apoptosis requires functional multidrug resistance-associated proteins
    • Hammond CL, Marchan R, Krance SM, Ballatori N. Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. J. Biol. Chem. 2007 282 : 14337 14347.
    • (2007) J. Biol. Chem. , vol.282 , pp. 14337-14347
    • Hammond, C.L.1    Marchan, R.2    Krance, S.M.3    Ballatori, N.4
  • 7
    • 0030063480 scopus 로고    scopus 로고
    • Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump
    • Jedlitschky G, Leier I, Buchholz U, Barnouin K, Kurz G, Keppler D. Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res. 1996 56 : 988 994. (Pubitemid 26065391)
    • (1996) Cancer Research , vol.56 , Issue.5 , pp. 988-994
    • Jedlitschky, G.1    Leier, I.2    Buchholz, U.3    Barnouin, K.4    Kurz, G.5    Keppler, D.6
  • 8
    • 0027960078 scopus 로고
    • Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells
    • Cole SP, Sparks KE, Fraser K et al. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res. 1994 54 : 5902 5910.
    • (1994) Cancer Res. , vol.54 , pp. 5902-5910
    • Cole, S.P.1    Sparks, K.E.2    Fraser, K.3
  • 9
    • 3543045528 scopus 로고    scopus 로고
    • Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required
    • Leslie EM, Haimeur A, Waalkes MP. Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required. J. Biol. Chem. 2004 279 : 32700 32708.
    • (2004) J. Biol. Chem. , vol.279 , pp. 32700-32708
    • Leslie, E.M.1    Haimeur, A.2    Waalkes, M.P.3
  • 10
    • 0033152212 scopus 로고    scopus 로고
    • Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2
    • Hooijberg JH, Broxterman HJ, Kool M et al. Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res. 1999 59 : 2532 2535.
    • (1999) Cancer Res. , vol.59 , pp. 2532-2535
    • Hooijberg, J.H.1    Broxterman, H.J.2    Kool, M.3
  • 11
    • 13044294031 scopus 로고    scopus 로고
    • MRP3, an organic anion transporter able to transport anti-cancer drugs
    • Kool M, van der Linden M, de Haas M et al. MRP3, an organic anion transporter able to transport anti-cancer drugs. Proc. Natl Acad. Sci. USA 1999 96 : 6914 6919.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 6914-6919
    • Kool, M.1    Van Der Linden, M.2    De Haas, M.3
  • 12
    • 41349107158 scopus 로고    scopus 로고
    • Multidrug resistance protein 4 (MRP4/ABCC4): A versatile efflux transporter for drugs and signalling molecules
    • Russel FG, Koenderink JB, Masereeuw R. Multidrug resistance protein 4 (MRP4/ABCC4): A versatile efflux transporter for drugs and signalling molecules. Trends Pharmacol. Sci. 2008 29 : 200 207.
    • (2008) Trends Pharmacol. Sci. , vol.29 , pp. 200-207
    • Russel, F.G.1    Koenderink, J.B.2    Masereeuw, R.3
  • 13
    • 0036606023 scopus 로고    scopus 로고
    • Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system
    • Chen ZS, Lee K, Walther S et al. Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 62 : 3144 3150.
    • (2002) Cancer Res. , vol.62 , pp. 3144-3150
    • Chen, Z.S.1    Lee, K.2    Walther, S.3
  • 14
    • 0032879904 scopus 로고    scopus 로고
    • MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
    • Schuetz JD, Connelly MC, Sun DX et al. MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat. Med. 1999 5 : 1048 1051.
    • (1999) Nat. Med. , vol.5 , pp. 1048-1051
    • Schuetz, J.D.1    Connelly, M.C.2    Sun, D.X.3
  • 15
    • 27744593512 scopus 로고    scopus 로고
    • Prostanoid transport by multidrug resistance protein 4 (MRP4/ABCC4) localized in tissues of the human urogenital tract
    • Rius M, Thon WF, Keppler D, Nies AT. Prostanoid transport by multidrug resistance protein 4 (MRP4/ABCC4) localized in tissues of the human urogenital tract. J. Urol. 2005 174 : 2409 2414.
    • (2005) J. Urol. , vol.174 , pp. 2409-2414
    • Rius, M.1    Thon, W.F.2    Keppler, D.3    Nies, A.T.4
  • 16
    • 0035823559 scopus 로고    scopus 로고
    • Transport of cyclic nucleotides and estradiol 17-β-d-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine
    • Chen ZS, Lee K, Kruh GD. Transport of cyclic nucleotides and estradiol 17-β-d-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine. J. Biol. Chem. 2001 276 : 33747 33754.
    • (2001) J. Biol. Chem. , vol.276 , pp. 33747-33754
    • Chen, Z.S.1    Lee, K.2    Kruh, G.D.3
  • 17
    • 0033975098 scopus 로고    scopus 로고
    • Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
    • Wijnholds J, deLange EC, Scheffer GL et al. Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J. Clin. Invest. 2000 105 : 279 285.
    • (2000) J. Clin. Invest. , vol.105 , pp. 279-285
    • Wijnholds, J.1    Delange, E.C.2    Scheffer, G.L.3
  • 18
    • 0036829109 scopus 로고    scopus 로고
    • Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6)
    • Belinsky MG, Chen ZS, Shchaveleva I, Zeng H, Kruh GD. Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res. 2002 62 : 6172 6177.
    • (2002) Cancer Res. , vol.62 , pp. 6172-6177
    • Belinsky, M.G.1    Chen, Z.S.2    Shchaveleva, I.3    Zeng, H.4    Kruh, G.D.5
  • 20
    • 3142752689 scopus 로고    scopus 로고
    • Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): Resistance to docetaxel
    • Hopper-Borge E, Chen ZS, Shchaveleva I, Belinsky MG, Kruh GD. Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): Resistance to docetaxel. Cancer Res. 2004 64 : 4927 4930.
    • (2004) Cancer Res. , vol.64 , pp. 4927-4930
    • Hopper-Borge, E.1    Chen, Z.S.2    Shchaveleva, I.3    Belinsky, M.G.4    Kruh, G.D.5
  • 22
    • 33846826935 scopus 로고    scopus 로고
    • MRP8/ABCC11 directly confers resistance to 5-fluorouracil
    • Oguri T, Bessho Y, Achiwa H et al. MRP8/ABCC11 directly confers resistance to 5-fluorouracil. Mol. Cancer Ther. 2007 6 : 122 127.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 122-127
    • Oguri, T.1    Bessho, Y.2    Achiwa, H.3
  • 23
    • 0042531890 scopus 로고    scopus 로고
    • MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2′,3′-dideoxycytidine and 9′-(2′-phosphonylmethoxyethyl) adenine
    • Guo Y, Kotova E, Chen ZS et al. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2′,3′-dideoxycytidine and 9′-(2′-phosphonylmethoxyethyl) adenine. J. Biol. Chem. 2003 278 : 29509 29514.
    • (2003) J. Biol. Chem. , vol.278 , pp. 29509-29514
    • Guo, Y.1    Kotova, E.2    Chen, Z.S.3
  • 24
    • 0037076375 scopus 로고    scopus 로고
    • MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer
    • Bera TK, Iavarone C, Kumar V, Lee S, Lee B, Pastan I. MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer. Proc. Natl Acad. Sci. USA 2002 99 : 6997 7002.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 6997-7002
    • Bera, T.K.1    Iavarone, C.2    Kumar, V.3    Lee, S.4    Lee, B.5    Pastan, I.6
  • 25
    • 0034072174 scopus 로고    scopus 로고
    • Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions
    • Bakos E, Evers R, Sinko E, Varadi A, Borst P, Sarkadi B. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol. Pharmacol. 2000 57 : 760 768.
    • (2000) Mol. Pharmacol. , vol.57 , pp. 760-768
    • Bakos, E.1    Evers, R.2    Sinko, E.3    Varadi, A.4    Borst, P.5    Sarkadi, B.6
  • 26
    • 0037047386 scopus 로고    scopus 로고
    • 125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain
    • 125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain. J. Biol. Chem. 2002 277 : 28690 28699.
    • (2002) J. Biol. Chem. , vol.277 , pp. 28690-28699
    • Mao, Q.1    Qiu, W.2    Weigl, K.E.3
  • 27
    • 0346728729 scopus 로고    scopus 로고
    • The ABCs of drug transport in intestine and liver: Efflux proteins limiting drug absorption and bioavailability
    • Chan LM, Lowes S, Hirst BH. The ABCs of drug transport in intestine and liver: Efflux proteins limiting drug absorption and bioavailability. Eur. J. Pharm. Sci. 2004 21 : 25 51.
    • (2004) Eur. J. Pharm. Sci. , vol.21 , pp. 25-51
    • Chan, L.M.1    Lowes, S.2    Hirst, B.H.3
  • 28
    • 47349110179 scopus 로고    scopus 로고
    • Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition
    • Zhou SF. Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition. Xenobiotica 2008 38 : 802 832.
    • (2008) Xenobiotica , vol.38 , pp. 802-832
    • Zhou, S.F.1
  • 29
    • 36949010980 scopus 로고    scopus 로고
    • Multidrug resistance associated proteins as determining factors of pharmacokinetics and pharmacodynamics of drugs
    • Yu XQ, Xue CC, Wang G, Zhou SF. Multidrug resistance associated proteins as determining factors of pharmacokinetics and pharmacodynamics of drugs. Curr. Drug Metab. 2007 8 : 787 802.
    • (2007) Curr. Drug Metab. , vol.8 , pp. 787-802
    • Yu, X.Q.1    Xue, C.C.2    Wang, G.3    Zhou, S.F.4
  • 30
    • 59049104003 scopus 로고    scopus 로고
    • Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy
    • Noguchi K, Katayama K, Mitsuhashi J, Sugimoto Y. Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy. Adv. Drug Deliv. Rev. 2009 61 : 26 33.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 26-33
    • Noguchi, K.1    Katayama, K.2    Mitsuhashi, J.3    Sugimoto, Y.4
  • 31
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • Juliano RL, Ling V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim. Biophys. Acta 1976 455 : 152 162.
    • (1976) Biochim. Biophys. Acta , vol.455 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 32
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer. Role of ATP-dependent transporters
    • Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer. Role of ATP-dependent transporters. Nat. Rev. Cancer 2002 2 : 48 58.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 33
    • 70349110758 scopus 로고    scopus 로고
    • Role of multidrug resistance associated proteins in drug development
    • Zhou SF. Role of multidrug resistance associated proteins in drug development. Drug Discov. Ther. 2008 2 : 305 332.
    • (2008) Drug Discov. Ther. , vol.2 , pp. 305-332
    • Zhou, S.F.1
  • 34
    • 36048948042 scopus 로고    scopus 로고
    • Harnessing drug resistance: Using ABC transporter proteins to target cancer cells
    • Leitner HM, Kachadourian R, Day BJ. Harnessing drug resistance: Using ABC transporter proteins to target cancer cells. Biochem. Pharmacol. 2007 74 : 1677 1685.
    • (2007) Biochem. Pharmacol. , vol.74 , pp. 1677-1685
    • Leitner, H.M.1    Kachadourian, R.2    Day, B.J.3
  • 35
    • 10344227755 scopus 로고    scopus 로고
    • Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: Effect of transport substrates and characterization of the post-hydrolysis transition state
    • Sauna ZE, Nandigama K, Ambudkar SV. Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: Effect of transport substrates and characterization of the post-hydrolysis transition state. J. Biol. Chem. 2004 279 : 48855 48864.
    • (2004) J. Biol. Chem. , vol.279 , pp. 48855-48864
    • Sauna, Z.E.1    Nandigama, K.2    Ambudkar, S.V.3
  • 36
    • 73949119171 scopus 로고    scopus 로고
    • Epothilones: Tubulin polymerization as a novel target for prostate cancer therapy
    • Lee JJ, Kelly WK. Epothilones: Tubulin polymerization as a novel target for prostate cancer therapy. Nat. Clin. Pract. Oncol. 2009 6 : 85 92.
    • (2009) Nat. Clin. Pract. Oncol. , vol.6 , pp. 85-92
    • Lee, J.J.1    Kelly, W.K.2
  • 38
    • 0035881280 scopus 로고    scopus 로고
    • A novel 7-modified camptothecin analog overcomes breast cancer resistance protein-associated resistance in a mitoxantrone-selected colon carcinoma cell line
    • Perego P, De Cesare M, De Isabella P et al. A novel 7-modified camptothecin analog overcomes breast cancer resistance protein-associated resistance in a mitoxantrone-selected colon carcinoma cell line. Cancer Res. 2001 61 : 6034 6037.
    • (2001) Cancer Res. , vol.61 , pp. 6034-6037
    • Perego, P.1    De Cesare, M.2    De Isabella, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.