Effect of arachidonic acid on hypoxia-induced IL-6 production in mouse ES cells: Involvement of MAPKs, NF-κB, and HIF-1α

Journal of Cellular Physiology

Volumn 222, Issue 3, 2010, Pages 574-585

  Lee, Sang Hun ^a   Lee, Yu Jin ^a   Han, Ho Jae ^a  

^a Chonnam National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; ASCORBIC ACID; GELATINASE A; GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; INTERLEUKIN 6 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA SYNTHESIS; EMBRYO; EMBRYONIC STEM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; HYPOXIA; MOUSE; MOUSE EMBRYO; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; ARACHIDONIC ACID; CELL CYCLE PROTEINS; CELL HYPOXIA; CELL PROLIFERATION; CELLS, CULTURED; DNA REPLICATION; EMBRYONIC STEM CELLS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEASE INHIBITORS; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; UP-REGULATION;

EID: 73649084405     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21973     Document Type: Article

References (45)

1. Angelucci A, Garofalo S, Speca S, Bovadilla A, Gravina GL, Muzi P, Vicentini C, Bologna M. 2008. Arachidonic acid modulates the crosstalk between prostate carcinoma and bone stromal cells. Endocr Relat Cancer 15:91-100.
2. Black SM, DeVol JM,Wedgwood S. 2008. Regulation of fibroblast growth factor-2 expression in pulmonary arterial smooth muscle cells involves increased reactive oxygen species generation. Am J Physiol Cell Physiol 294:C345-C354.
3. Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T, Nebelsiek T, Lundgren-May T, Canli O, Schwitalla S, Matthews V, Schmid RM, Kirchner T, Arkan MC, Ernst M, Greten FR. 2009. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 15:91-102.
4. Bordin L, Priante G, Musacchio E, Giunco S, Tibaldi E, Clari G, Baggio B. 2003. Arachidonic acid-induced IL-6 expression is mediated by PKC a activation in osteoblastic cells. Biochemistry 42:4485-4491.
5. Brett CM, Washington CB, Ott RJ, Gutierrez MM, Giacomini KM. 1993. Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney. Pharm Res 10:423-426.
6. Bruick RK. 2003. Oxygen sensing in the hypoxic response pathway: Regulation of the hypoxia-inducible transcription factor. Genes Dev 17:2614-2623.
7. Carlson SE, Cook RJ,Werkman SH, Tolley EA. 1992. First year growth of preterm infants fed standard compared to marine oil n-3 supplemented formula. Lipids 27:901-907.
8. Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT. 1998. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA 95:11120-11715.
9. Csete M. 2005. Oxygen in the cultivation of stem cells. Ann N Y Acad Sci 1049:1-8.
10. Duyndam MC, Hulscher ST, van derWall E, Pinedo HM, Boven E. 2003. Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite. J Biol Chem 278:6885-6895.
11. Ezashi T, Das P, Roberts RM. 2005. Low O2 tensions and the prevention of differentiation of hES cells. Proc Natl Acad Sci USA 102:4783-4788.
12. Fiebich BL, Hüll M, Lieb K, Gyufko K, Berger M, Bauer J. 1997. Prostaglandin E2 induces interleukin-6 synthesis in human astrocytoma cells. J Neurochem 68:704-709.
13. Fiebich BL, Hüll M, Lieb K, Schumann G, Berger M, Bauer J. 1998. Potential link between interleukin-6 and arachidonic acid metabolism in Alzheimer's disease. J Neural Transm 54:268-278.
14. Giatromanolaki A, Harris AL. 2001. Tumour hypoxia, hypoxia signaling pathways and hypoxia inducible factor expression in human cancer. Anticancer Res 21:4317-4324.
15. HaradaH, Itasaka S, Kizaka-Kondoh S, Shibuya K, Morinibu A, Shinomiya K, Hiraoka M. 2009. Akt/mTOR pathway assures the synthesis of HIF-1a protein in a glucose- and reoxygenation-dependent manner in irradiated tumors. J Biol Chem 284:5332-5342.
16. Harris AL. 2002. Hypoxia-A key regulatory factor in tumour growth. Nat Rev Cancer 2:38-47.
17. Holladay CS, Wright RM, Spangelo BL. 1993. Arachidonic acid stimulates interleukin-6 release from rat peritoneal macrophages in vitro: Evidence for a prostacyclin-dependent mechanism. Prostaglandins Leukot Essent Fatty Acids 49:915-922.
18. Hov H, Tian E, Holien T, Holt RU, Vå tsveen TK, Fagerli UM, Waage A, Børset M, Sundan A. 2009. c-Met signaling promotes IL-6-induced myeloma cell proliferation. Eur J Haematol 82:277-287.
19. Jeong HJ, Hong SH, Park RK, Shin T, An NH, Kim HM. 2005. Hypoxia-induced IL-6 production is associated with activation of MAP kinase, HIF-1, and NF-kB on HEI-OC1 cells. Hear Res 207:59-67.
20. Kang MK, Kang SK. 2008. Interleukin-6 induces proliferation in adult spinal cord-derived neural progenitors via the JAK2/STAT3 pathway with EGF-induced MAPK phosphorylation. Cell Prolif 41:377-392.
21. Krstić A, Vlaski M, Hammoud M, Chevaleyre J, Duchez P, Jovčić G, Bugarski D, Milenković P, Bourin P, Boiron JM, Praloran V, Ivanović Z. 2008. Low O2 concentrations enhance the positive effect of IL-17 on the maintenance of erythroid progenitors during co-culture of CD34+ and mesenchymal stem cells. Eur Cytokine Netw 20:10-16.
22. Lambert IH, Pedersen SF, Poulsen KA. 2006. Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia. Acta Physiol 187:75-85.
23. Lander HM. 1997.An essential role for free radicals and derived species in signal transduction. FASEB J 11:118-124.
24. Lee SH, Heo JS, Han HJ. 2007. Effect of hypoxia on 2-deoxyglucose uptake and cell cycle regulatory protein expression of mouse embryonic stem cells: Involvement of Ca2+ /PKC, MAPKs and HIF-1a. Cell Physiol Biochem 19:269-282.
25. Lee SH, Lee MY, Han HJ. 2008. Short-period hypoxia increases mouse embryonic stem cell proliferation through cooperation of arachidonic acid and PI3K/Akt signalling pathways. Cell Prolif 41:230-247.
26. Lee SH, Kim MH, Han HJ. 2009. Arachidonic acid potentiates hypoxia-induced VEGF expression in mouse embryonic stem cells: Involvement of Notch, Wnt, and HIF-1a. Am J Physiol Cell Physiol 297:C207-C216.
27. Malinowska K, Neuwirt H, Cavarretta IT, Bektic J, Steiner H, Dietrich H, Moser PL, Fuchs D, Hobisch A, Culig Z. 2009. Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor. Endocr Relat Cancer 16:155-169.
28. Matsuia H, Iharaa Y, Fujioa Y, Kunisadaa K, Akirab S, Kishimotoa T, Yamauchi-Takiharaa K. 1999. Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-κB and NF-IL6 in cardiac myocytes. Cardiovasc Res 42:104-112.
29. 2) inhibitors. Biochem Pharmacol 63:321-332.
30. Mottet D, Michel G, Renard P, Ninane N, Raes M, MichielsC. 2003. Role of ERK and calcium in the hypoxia-induced activation of HIF-1. J Cell Physiol 194:30-44.
31. Osorio-Fuentealba C, Valdes JA, Riquelme D, Hidalgo J, Hidalgo C, Carrasco MA. 2009. Hypoxia stimulates via separate pathways ERK phosphorylation and NF-κB activation in skeletal muscle cells in primary culture. J Appl Physiol 106:1301-1310.
32. Prata C, Maraldi T, Zambonin L, Fiorentini D, Hakim G, Landi L. 2004. ROS production and Glut1 activity in two human megakaryocytic cell lines. Biofactors 20:223-233.
33. Savale L, Tu L, RideauD, Izziki M, Maitre B, Adnot S, Eddahibi S. 2009. Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice. Respir Res 10:6-19.
34. Sellmayer A, Koletzko B. 1999. Long-chain polyunsaturated fatty acids and eicosanoids in infants-Physiological and pathophysiological aspects and open questions. Lipids 34:199-205.
35. Smith AG. 2001. Embryo-derived stem cells: of mice and men. Annu Rev Cell Dev Biol 17:435-462.
36. Suh HN, Lee SH, Lee MY, Lee YJ, Lee JH, Han HJ. 2008. Role of interleukin-6 in the control of DNA synthesis of hepatocytes: Involvement of PKC, p44/42 MAPKs, and PPARdelta. Cell Physiol Biochem 22:673-684.
37. Trayhurn P,Wang B, Wood IS. 2008. Hypoxia and the endocrine and signaling role of white adipose tissue. Arch Physiol Biochem 114:267-276.
38. Verlengia R, Gorjão R,Kanunfre CC, Bordin S, de Lima TM, CuriR. 2003. Effect of arachidonic acid on proliferation, cytokines production and pleiotropic genes expression in Jurkat cells - A comparison with oleic acid. Life Sci 73:2939-2951.
39. 2 tension. Proc Natl Acad Sci USA 92:5510-5514.
40. Weissman IL, Anderson DJ, Gage F. 2001. Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol 17:387-403.
41. Woo MS, Park JS, Choi IY, Kim WK, Kim HS. 2008. Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microglia. J Neurochem 106:770-780.
42. Xie K. 2001. Interleukin-8 and human cancer biology. Cytokine Growth Factor Rev 12:375-391.
43. Yan SF, Tritto I, Pinsky D, Liao H, Huang J, Fuller G, Brett J,May L, Stern D. 1995. Induction of interleukin 6 (IL-6) by hypoxia in vascular cells. Central role of the binding site for nuclear factor-IL-6. J Biol Chem 270:11463-11471.
44. Yao JS, Zhai W, Young WL, Yang GY. 2006. Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: The role for KDR and MMP-9. Biochem Biophys Res Commun 342:1396-1404.
45. Zhang E, Li X, Zhang S, Chen L, Zheng X. 2005. Cell cycle synchronization of embryonic stem cells: Effect of serum deprivation on the differentiation of embryonic bodies in vitro. Biochem Biophys Res Commun 333:1171-1177.