A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells

European Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2010, Pages 705-709

  Hu, Changkun ^a   Raja Solomon, V ^a,b   Cano, Pablo ^a   Lee, Hoyun ^a,b,c  

^a SUDBURY REGIONAL HOSPITAL   (Canada)

^b LAURENTIAN UNIVERSITY   (Canada)

^c NORTHERN ONTARIO SCHOOL OF MEDICINE   (Canada)

Author keywords

184B5; Akt inhibitor; Breast cancer; Chemotherapeutics; Chloroquine analog

Indexed keywords

1 [1 [4 ( 7 PHENYL 1H IMIDAZOL[4,5 G]QUINOXALIN 6 YL) BENZYL] PIPERIDIN 4 YL] 1,3 DIHYDRO BENZIOMIDAZOL 2 ONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 AMINOQUINOLINE DERIVATIVE; 6 BENZOTHIAZOL 2 YL 1 ETHYL 2 [2 (METHYLPHENYLAMINO) VINYL] 3 PHENYL 3H BENZOIMIDAZOL 1 IUM IODIDE; [4 (2 CHLORO 4 ALPHA,10 ALPHA DIHYDROPHENOXAZIN 10 YL) BUTYL] DIETHYLAMINE HYDROCHLORIDE; BUTYL (7 CHLOROQUINOLIN 4 YL) AMINE; BUTYL (7 FLUOROQUINOLIN 4 YL) AMINE; CHLOROQUINE; N' (7 CHLOROQUINOLIN 4 YL) N,N DIMETHYLETHANE 1,2 DIAMINE; N' (7 FLUOROQUINOLIN 4 YL) N,N DIMETHYLETHANE 1,2 DIAMINE; N' (7 METHOXYQUINOLIN 4 YL) N,N DIMETHYLETHANE 1,2 DIAMINE; PROTEIN KINASE B INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER CONTROL; CELL KILLING; CELL STRAIN MCF 7; CHEMOSENSITIZATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENTIATION; DRUG SPECIFICITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; STRUCTURE ANALYSIS; TUMOR CELL DESTRUCTION;

AMINOQUINOLINES; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; HUMANS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 73549120401     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.11.017     Document Type: Article

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