Connective tissue growth factor promoter activity in normal and wounded skin

Fibrogenesis and Tissue Repair

Volumn 1, Issue 1, 2008, Pages

  Kapoor, Mohit ^a   Liu, Shangxi ^a   Huh, Kun ^a   Parapuram, Sunil ^a   Kennedy, Laura ^a   Leask, Andrew ^a  

^a WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 67349162849     PISSN: None     EISSN: 17551536     Source Type: Journal    
DOI: 10.1186/1755-1536-1-3     Document Type: Article

References (27)

1. Hinz B, Gabbiani G. Mechanisms of force generation and transmission by myofibroblasts. Curr Opin Biotechnol 2003, 14:538-546.
2. Desmouliere A, Chaponnier C, Gabbiani G. Tissue repair, contraction, and the myofibroblast. Wound Repair Regen 2005, 13:7-12.
3. Chen Y, Shi-wen X, van Beek J, Kennedy L, McLeod M, Renzoni EA, Bou-Gharios G, Wilcox-Adelman S, Goetinck PF, Eastwood M, Black CM, Abraham DJ, Leask A. Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease. Am J Pathol 2005, 67:1699-1711.
4. Abraham DJ, Eckes B, Rajkumar V, Krieg T. New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma. Curr Rheumatol Rep 2007, 9:136-143.
5. Rajkumar VS, Shi-wen X, Bostrom M, Leoni P, Muddle J, Ivarsson M, Gerdin B, Denton CP, Bou-Gharios G, Black CM, Abraham DJ. Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing. Am J Pathol 2006, 169:2254-2265. 1762470, 17148686.
6. Leask A, Abraham DJ. All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J Cell Sci 2006, 119:4803-4810.
7. Lau LF, Lam SC. The CCN family of angiogenic regulators: the integrin connection. Exp Cell Res 1999, 248:44-57.
8. Chen Y, Abraham DJ, Shi-wen X, Pearson JD, Black CM, Lyons KM, Leask A. CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell 2004, 15:5635-5646. 532042, 15371538.
9. Shi-wen X, Stanton LA, Kennedy L, Pala D, Chen Y, Howat SL, Renzoni EA, Carter DE, Bou-Gharios G, Stratton RJ, Pearson JD, Beier F, Lyons KM, Black CM, Abraham DJ, Leask A. CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts. J Biol Chem 2006, 281:10715-10726.
10. Gao R, Brigstock DR. Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan. J Biol Chem 2004, 279:8848-8855.
11. Igarashi A, Okochi H, Bradham DM, Grotendorst GR. Regulation of connective tissue growth factor gene expression in human skinfibroblasts and during wound repair. Mol Biol Cell 1993, 4:637-645. 300970, 8374172.
12. Ivkovic S, Yoon BS, Popoff SN, Safadi FF, Libuda DE, Stephenson RC, Daluiski A, Lyons KM. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 2003, 130:2779-2791.
13. Blom IE, Goldschmeding R, Leask A. Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?. Matrix Biol 2002, 21:473-482.
14. Holmes A, Abraham DJ, Sa S, Shi-wen X, Black CM, Leask A. CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. J Biol Chem 2001, 276:10594-10601.
15. Chen Y, Blom IE, Sa S, Goldschmeding R, Abraham DJ, Leask A. CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC. Kidney Int 2002, 62:1149-1159.
16. Leask A, Holmes A, Black CM, Abraham DJ. Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts. J Biol Chem 2003, 278:13008-13015.
17. Pickles M, Leask A. Analysis of the CCN2 promoter in PANC-1 cells: regulation by ras/MEK/ERK. J Cell Commun Signal 2007, 1:85-90. 2275873, 18481199.
18. Jones JA, Gray MR, Oliveira BE, Koch M, Castellot JJ. CCN5 expression in mammals I. Embryonic and fetal tissues of mouse and human. J Cell Commun Signal 2007, 1:127-143. 2275877, 18481203.
19. Gray MR, Malmquist JA, Sullivan M, Blea M, Castellot JJ. CCN5 expression in mammals. II. Adult rodent tissues. J Cell Commun Signal 2007, 1:145-158. 2275874, 18481204.
20. Quan T, He T, Kang S, Voorhees JJ, Fisher GJ. Ultraviolet irradiation alters transforming growth factor beta/smad pathway in human skin in vivo. J Invest Dermatol 2002, 119:499-506.
21. Arnone MI, Dmochowski IJ, Gache C. Using reporter genes to study cis-regulatory elements. Methods Cell Biol 2004, 74:621-652.
22. Seymour PA, Sander M. Immunohistochemical detection of beta-galactosidase or green fluorescent protein on tissue sections. Methods Mol Biol 2007, 411:13-24.
23. Gong S, Zheng C, Doughty ML, Losos K, Didkovsky N, Schambra UB, Nowak NJ, Joyner A, Leblanc G, Hatten ME, Heintz N. A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. Nature 2003, 425:917-925.
24. Shi-wen X, Howat SL, Renzoni EA, Holmes A, Pearson JD, Dashwood MR, Bou-Gharios G, Denton CP, du Bois RM, Black CM, Leask A, Abraham DJ. Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. J Biol Chem 2004, 279:23098-23103.
25. Leask A, Abraham DJ. TGF-beta signaling and the fibrotic response. FASEB J 2004, 18:816-827.
26. MMRRC. , http://www.mmrrc.org/
27. EGFP Genotyping Protocol. , http://www.mmrrc.org/strains/Gensat/EGFP_PCR.html