Intrinsic structural disorder confers cellular viability on oncogenic fusion proteins

PLoS Computational Biology

Volumn 5, Issue 10, 2009, Pages

  Hegyi, Hedi ^a   Buday, László ^a,b   Tompa, Peter ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYMES; HYDROPHOBICITY; SURFACE CHEMISTRY; TRANSCRIPTION;

BREAKPOINT; CELLULAR VIABILITY; CHROMOSOMAL TRANSLOCATIONS; DOMAIN SPLITTING; FUSION PROTEINS; HUMAN PROTEINS; KINASE DOMAINS; ONCOGENICS; STRUCTURAL DISORDERS; TYROSINE KINASE;

PHOSPHORYLATION;

BCR ABL PROTEIN; CHIMERIC PROTEIN; HOMODIMER; HYBRID PROTEIN; PROTEIN; PROTEIN PFAM; PROTEIN SUBUNIT; PROTEIN TYROSINE KINASE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ONCOPROTEIN;

ARTICLE; CATALYSIS; CELL VIABILITY; CHROMOSOME TRANSLOCATION; DIMERIZATION; DNA BINDING; DOUBLE STRANDED DNA BREAK; GENE TRANSLOCATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; INTRAUTERINE CONTRACEPTIVE DEVICE; NEOPLASM; NUCLEOTIDE SEQUENCE; ONCOGENE; PHOSPHORYLATION; PREDICTION; PROMOTER REGION; PROTEIN BINDING; PROTEIN FOLDING; SIGNAL TRANSDUCTION; SURFACE PROPERTY; ALGORITHM; BIOLOGY; CELL SURVIVAL; CELL TRANSFORMATION; CHEMICAL STRUCTURE; CHEMISTRY; CHROMOSOME BREAKAGE; COMPUTER SIMULATION; GENETICS; METHODOLOGY; PHYSIOLOGY; PROTEIN CONFORMATION; STATISTICAL MODEL;

ALGORITHMS; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME BREAKAGE; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; HUMANS; LOGISTIC MODELS; MODELS, MOLECULAR; ONCOGENE PROTEINS, FUSION; ONCOGENES; PROTEIN CONFORMATION; PROTEIN FOLDING; TRANSLOCATION, GENETIC;

EID: 73549101052     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000552     Document Type: Article

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