Synthesis of variously substituted 3-phenoxymethyl quinoxalin-2-ones and quinoxalines capable to potentiate in vitro the antiproliferative activity of anticancer drugs in multi-drug resistant cell lines

Medicinal Chemistry

Volumn 2, Issue 2, 2006, Pages 113-122

  Carta, Antonio ^a   Loriga, Mario ^a   Piras, Sandra ^a   Paglietti, Giuseppe ^a   La Colla, Paolo ^b   Busonera, Bernardetta ^b   Collu, Gabriella ^b   Loddo, Roberta ^b  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

2 Quinoxalinones; Antiproliferative activity; Doxorubicin; Etoposide; Multidrug resistance; P glycoprotein inhibitors; Quinoxalines; Vincristine

Indexed keywords

1 BENZYL 3 BROMOMETHYL 7 TRIFLUOROMETHYLQUINOXALINE 2 ONE; 1 BENZYL 3 DIBROMOMETHYL 7 TRIFLUOROMETHYLQUINOXALIN 2 ONE; 1 BENZYL 3 METHYL 7 TRIFLUOROMETHYLQUINOXALINE 2 ONE; 1 BENZYL 3 PHENOXYMETHYL 7 TRIFLUOROMETHYLQUINOXALIN 2 ONE DERIVATIVE; 1 BENZYL 7 TRIFLUOROMETHYL 3 (2 BENZAMIDEOHENOXYMETHYL)QUINOXALINE 2 ONE; 1 BENZYL 7 TRIFLUOROMETHYL 3 (4 BENZOYLPHENOXYMETHYL)QUINOXALINE 2 ONE; 1 BENZYL 7 TRIFLUOROMETHYL 3 (4 CIANOPHENOXYMETHYL)QUINOXALINE 2 ONE; 1 BENZYL 7 TRIFLUROMETHYL 3 (4 METHOXYPHENOXYMETHYL)QUINOXALINE 2 ONE; 1,6 DIMETHYL 3 (2 BENZAMIDEPHENOXYMETHYL)QUINOXALINE 2 ONE; 1,6 DIMETHYL 3 (3,5 DIMETHOXYPHENOXYMETHYL)QUINOXALINE 2 ONE; 1,6 DIMETHYL 3 (4 BENZOYLPHENOXYMETHYL)QUINOXALINE 2 ONE; 1,6 DIMETHYL 3 (4 CARBOMETHOXY 2 METHOXYPHENOXYMETHYL)QUINOXALIN 2 ONE; 1,6 DIMETHYL 3 (4 CIANOPHENOXYMETHYL)QUINOXALINE 2 ONE; 1,6 DIMETHYL 3 (4 METHOXYPHENOXYMETHYL)QUINOXALINE 2 ONE; 1,6 DIMETHYL 3 PHENOXYMETHYLQUINOXALIN 2 ONE DERIVATIVE; 2 (4 BENZYL 3 OXO 3,4 DIHYDROQUINOXALIN 2 YLMETHOXY) N PHENYLBENZAMIDE; 2 BENZYLOXY 3 BROMOMETHYL 7 TRIFLUOROMETHYLQUINOXALINE; 2 BENZYLOXY 3 BROMOMETHYL 7 TRIFLUROMETHYLQUINOXALINE; 2 BENZYLOXY 3 DIBROMOMETHYL 7 TRIFLUOROMETHYLQUINOXALINE; 2 BENZYLOXY 3 METHYL 7 TRIFLUOROMETHYLQUINOXALINE; 2 BENZYLOXY 3 PHENOXYMETHYL 7 TRIFLUOROMETHYLQUINOXALINE; 3 BROMOMETHYL 1,6 DIMETHYLQUINOXALIN 2 ONE; 3 METHYL 7 TRIFLUOROMETHYLQUINOXALINE 2 ONE; ANTINEOPLASTIC AGENT; DOXORUBICIN; ETOPOSIDE; GLYCOPROTEIN P; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MULTIDRUG RESISTANCE; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE; CELL PROLIFERATION; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG SYNERGISM; ETOPOSIDE; HUMANS; KB CELLS; NEOPLASMS; P-GLYCOPROTEIN; QUINOXALINES; TUMOR CELLS, CULTURED; VINCRISTINE;

EID: 33746110347     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340606776056197     Document Type: Article

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