Impaired methylation as a novel mechanism for proteasome suppression in liver cells

Biochemical and Biophysical Research Communications

Volumn 391, Issue 2, 2010, Pages 1291-1296

  Osna, Natalia A ^a,b   White, Ronda L ^a,b   Donohue Jr , Terrence M ^a,b   Beard, Michael R ^c   Tuma, Dean J ^a,b   Kharbanda, Kusum K ^a,b  

^a VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

20S proteasome; Hepatocytes; Hepatoma cells; Methyl lysine; S Adenosylhomocysteine; S Adenosylmethionine

Indexed keywords

ADENOSYLHOMOCYSTEINASE; ALCOHOL; CHYMOTRYPSIN; PROTEASOME; S ADENOSYLMETHIONINE; TUBERCIDIN;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; ERYTHROCYTE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LIVER CELL; LIVER CELL NUCLEUS; LIVER CYTOSOL; NONHUMAN; PRIORITY JOURNAL; PROTEIN METHYLATION; RABBIT;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL LINE, TUMOR; CHYMOTRYPSIN; ETHANOL; HUMANS; LIVER; METHYLATION; MICE; MICE, INBRED C57BL; PROTEASOME ENDOPEPTIDASE COMPLEX; RABBITS; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE; TUBERCIDIN;

ORYCTOLAGUS CUNICULUS;

EID: 73449133690     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.12.074     Document Type: Article

References (32)

1. Donohue Jr. T.M., Cederbaum A.I., French S.W., Barve S., Gao B., and Osna N.A. Role of the proteasome in ethanol-induced liver pathology. Alcohol Clin. Exp. Res. 31 (2007) 1446-1459
2. Osna N.A., and Donohue Jr. T.M. Implication of altered proteasome function in alcoholic liver injury. World J. Gastroenterol. 13 (2007) 4931-4937
3. York I.A., Chang S.C., Saric T., Keys J.A., Favreau J.M., Goldberg A.L., and Rock K.L. The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat. Immunol. 3 (2002) 1177-1184
4. Osna N.A., White R.L., Todero S., McVicker B.L., Thiele G.M., Clemens D.L., Tuma D.J., and Donohue Jr. T.M. Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells. Hepatology 45 (2007) 53-61
5. Bardag-Gorce F., Li J., French B.A., and French S.W. The effect of ethanol-induced CYP2E1 on proteasome activity: the role of 4-hydroxynonenal. Exp. Mol. Pathol. 78 (2005) 109-115
6. Osna N., Clemens D., and Donohue Jr. T.M. Ethanol suppresses interferon gamma-mediated activation of the proteasome by preventing STAT1 phosphorylation in human recombinant Hep G2 cells. Hepatology 36 (2002) 334A (Abstract No. 684)
7. Bardag-Gorce F., Yuan Q.X., Li J., French B.A., Fang C., Ingelman-Sundberg M., and French S.W. The effect of ethanol-induced cytochrome p4502E1 on the inhibition of proteasome activity by alcohol. Biochem. Biophys. Res. Commun. 279 (2000) 23-29
8. Donohue T.M., Osna N.A., and Clemens D.L. Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity. Int. J. Biochem. Cell Biol. 38 (2006) 92-101
9. Farout L., Mary J., Vinh J., Szweda L.I., and Friguet B. Inactivation of the proteasome by 4-hydroxy-2-nonenal is site specific and dependant on 20S proteasome subtypes. Arch. Biochem. Biophys. 453 (2006) 135-142
10. Ishii T., Sakurai T., Usami H., and Uchida K. Oxidative modification of proteasome: identification of an oxidation-sensitive subunit in 26S proteasome. Biochemistry 44 (2005) 13893-13901
11. Osna N.A., Clemens D.L., and Donohue Jr. T.M. Interferon gamma enhances proteasome activity in recombinant Hep G2 cells that express cytochrome P4502E1: modulation by ethanol. Biochem. Pharmacol. 66 (2003) 697-710
12. Osna N.A., White R.L., Krutik V.M., Wang T., Weinman S.A., and Donohue Jr. T.M. Proteasome activation by hepatitis C core protein is reversed by ethanol-induced oxidative stress. Gastroenterology 134 (2008) 2144-2152
13. Li J., Bardag-Gorce F., Dedes J., French B.A., Amidi F., Oliva J., and French S.W. S-Adenosylmethionine prevents Mallory Denk body formation in drug-primed mice by inhibiting the epigenetic memory. Hepatology 47 (2008) 613-624
14. Bardag-Gorce F., Dedes J., French B.A., Oliva J.V., Li J., and French S.W. Mallory body formation is associated with epigenetic phenotypic change in hepatocytes in vivo. Exp. Mol. Pathol. 83 (2007) 160-168
15. Barak A.J., Beckenhauer H.C., Mailliard M.E., Kharbanda K.K., and Tuma D.J. Betaine lowers elevated S-adenosylhomocysteine levels in hepatocytes from ethanol-fed rats. J. Nutr. 133 (2003) 2845-2848
16. Kharbanda K.K. Role of transmethylation reactions in alcoholic liver disease. World J. Gastroenterol. 13 (2007) 4947-4954
17. Kharbanda K.K., Rogers II D.D., Mailliard M.E., Siford G.L., Barak A.J., Beckenhauer H.C., Sorrell M.F., and Tuma D.J. Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: protection by betaine. Biochem. Pharmacol. 70 (2005) 1883-1890
18. Kharbanda K.K., Todero S.L., Ward B.W., Cannella III J.J., and Tuma D.J. Betaine administration corrects ethanol-induced defective VLDL secretion. Mol. Cell. Biochem. 327 (2009) 75-78
19. Bardag-Gorce F. Nuclear effects of ethanol-induced proteasome inhibition in liver cells. World J. Gastroenterol. 15 (2009) 1163-1167
20. Oliva J., Dedes J., Li J., French S.W., and Bardag-Gorce F. Epigenetics of proteasome inhibition in the liver of rats fed ethanol chronically. World J. Gastroenterol. 15 (2009) 705-712
21. McCartney E.M., Semendric L., Helbig K.J., Hinze S., Jones B., Weinman S.A., and Beard M.R. Alcohol metabolism increases the replication of hepatitis C virus and attenuates the antiviral action of interferon. J. Infect. Dis. 198 (2008) 1766-1775
22. Otani K., Korenaga M., Beard M.R., Li K., Qian T., Showalter L.A., Singh A.K., Wang T., and Weinman S.A. Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells. Gastroenterology 128 (2005) 96-107
23. McMullen M.R., Pritchard M.T., Wang Q., Millward C.A., Croniger C.M., and Nagy L.E. Early growth response-1 transcription factor is essential for ethanol-induced fatty liver injury in mice. Gastroenterology 128 (2005) 2066-2076
24. Kessova I.G., and Cederbaum A.I. The effect of CYP2E1-dependent oxidant stress on activity of proteasomes in HepG2 cells. J. Pharmacol. Exp. Ther. 315 (2005) 304-312
25. Osna N.A., Haorah J., Krutik V.M., and Donohue Jr. T.M. Peroxynitrite alters the catalytic activity of rodent liver proteasome in vitro and in vivo. Hepatology 40 (2004) 574-582
26. Bardag-Gorce F., Oliva J., Villegas J., Fraley S., Amidi F., Li J., Dedes J., French B., and French S.W. Epigenetic mechanisms regulate Mallory Denk body formation in the livers of drug-primed mice. Exp. Mol. Pathol. 84 (2008) 113-121
27. McClain C., Barve S., Joshi-Barve S., Song Z., Deaciuc I., Chen T., and Hill D. Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver disease. Alcohol Clin. Exp. Res. 29 (2005) 180S-188S
28. D'Anselmi F., Cucina A., Cavallaro G., Bizzarri M., Cavallaro R.A., Fuso A., Cavallaro A., and Scarpa S. S-Adenosylmethionine inhibits ubiquitin-proteasome system in vitro and on rat vascular smooth muscle cells. Protein Pept. Lett. 15 (2008) 58-62
29. Goasduff T., and Cederbaum A.I. CYP2E1 degradation by in vitro reconstituted systems: role of the molecular chaperone hsp90. Arch. Biochem. Biophys. 379 (2000) 321-330
30. Goasduff T., and Cederbaum A.I. NADPH-dependent microsomal electron transfer increases degradation of CYP2E1 by the proteasome complex: role of reactive oxygen species. Arch. Biochem. Biophys. 370 (1999) 258-270
31. Gomes A.V., Young G.W., Wang Y., Zong C., Eghbali M., Drews O., Lu H., Stefani E., and Ping P. Contrasting proteome biology and functional heterogeneity of the 20S proteasome complexes in mammalian tissues. Mol. Cell. Proteomics 8 (2009) 302-315
32. Osna N.A. Hepatitis C virus and ethanol alter antigen presentation in liver cells. World J. Gastroenterol. 15 (2009) 1201-1208