Proteasome Activation by Hepatitis C Core Protein Is Reversed by Ethanol-Induced Oxidative Stress

Gastroenterology

Volumn 134, Issue 7, 2008, Pages 2144-2152

  Osna, Natalia A ^a,b   White, Ronda L ^a,b   Krutik, Viatcheslav M ^c   Wang, Ting ^d   Weinman, Steven A ^d   Donohue Jr , Terrence M ^a,b  

^a VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALLYL SULFIDE; CATALASE; CORE PROTEIN; CYTOCHROME P450 2E1; GLUTATHIONE ETHYL ESTER; PEPTIDASE; PROTEASOME;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIVER MICROSOME; LIVER MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; UPREGULATION;

EID: 44649095826     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.02.063     Document Type: Article

References (38)

1. Ulrich H.D., Vogel S., and Davies A.A. SUMO keeps a check on recombination during DNA replication. Cell Cycle 4 (2005) 1699-1702
2. Kim T.K., and Maniatis T. Regulation of interferon-γ-activated STAT1 by the ubiquitin-proteasome pathway. Science 273 (1996) 1717-1719
3. Rock K.L., York I.A., Saric T., et al. Protein degradation and the generation of MHC class I-presented peptides. Adv Immunol 80 (2002) 1-70
4. Wen F., Abdalla M.Y., Aloman C., et al. Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1. J Med Virol 72 (2004) 230-240
5. Wang T., and Weinman S.A. Causes and consequences of mitochondrial reactive oxygen species generation in hepatitis C. J Gastroenterol Hepatol 21 Suppl 3 (2006) S34-S37
6. Korenaga M., Okuda M., Otani K., et al. Mitochondrial dysfunction in hepatitis C. J Clin Gastroenterol 39 (2005) S162-S166
7. Otani K., Korenaga M., Beard M.R., et al. Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells. Gastroenterology 128 (2005) 96-107
8. Osna N.A., Clemens D.L., and Donohue Jr. T.M. Interferon γ enhances proteasome activity in recombinant Hep G2 cells that express cytochrome P4502E1: modulation by ethanol. Biochem Pharmacol 66 (2003) 697-710
9. Bardag-Gorce F., Li J., French B.A., et al. The effect of ethanol-induced CYP2E1 on proteasome activity: the role of 4-hydroxynonenal. Exp Mol Pathol 78 (2005) 109-115
10. Kessova I.G., and Cederbaum A.I. The effect of CYP2E1-dependent oxidant stress on activity of proteasomes in HepG2 cells. J Pharmacol Exp Ther 315 (2005) 304-312
11. Donohue T.M., Osna N.A., and Clemens D.L. Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity. Int J Biochem Cell Biol 38 (2006) 92-101
12. Osna N.A., White R.L., Todero S., et al. Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells. Hepatology 45 (2007) 53-61
13. Nevins C.L., Malaty H., Velez M.E., et al. Interaction of alcohol and hepatitis C virus infection on severity of liver disease. Dig Dis Sci 44 (1999) 1236-1242
14. Khan K.N., and Yatsuhashi H. Effect of alcohol consumption on the progression of hepatitis C virus infection and risk of hepatocellular carcinoma in Japanese patients. Alcohol Alcohol 35 (2000) 286-295
15. Beyette J.R., Hubbell T., and Monaco J.J. Purification of 20S proteasomes. Methods Mol Biol 156 (2001) 1-16
16. Chu-Ping M., Slaughter C.A., and DeMartino G.N. Purification and characterization of a protein inhibitor of the 20S proteasome (macropain). Biochim Biophys Acta 1119 (1992) 303-311
17. Kunkel M., Lorinczi M., Rijnbrand R., et al. Self-assembly of nucleocapsid-like particles from recombinant hepatitis C virus core protein. J Virol 75 (2001) 2119-2129
18. Brown E.A., Zhang H., Ping L.H., et al. Secondary structure of the 5' nontranslated regions of hepatitis C virus and pestivirus genomic RNAs. Nucleic Acids Res 20 (1992) 5041-5045
19. Donohue Jr. T.M., McVicker D.L., Kharbanda K.K., et al. Ethanol administration alters the proteolytic activity of hepatic lysosomes. Alcohol Clin Exp Res 18 (1994) 536-541
20. Hamel F.G., Bennett R.G., Harmon K.S., et al. Insulin inhibition of proteasome activity in intact cells. Biochem Biophys Res Commun 234 (1997) 671-674
21. Osna N.A., Haorah J., Krutik V.M., et al. Peroxynitrite alters the catalytic activity of rodent liver proteasome in vitro and in vivo. Hepatology 40 (2004) 574-582
22. Suzuki R., Tamura K., Li J., et al. Ubiquitin-mediated degradation of hepatitis C virus core protein is regulated by processing at its carboxyl terminus. Virology 280 (2001) 301-309
23. Shirakura M., Murakami K., Ichimura T., et al. E6AP ubiquitin ligase mediates ubiquitylation and degradation of hepatitis C virus core protein. J Virol 81 (2007) 1174-1185
24. Grune T., Klotz L.O., Gieche J., et al. Protein oxidation and proteolysis by the nonradical oxidants singlet oxygen or peroxynitrite. Free Radic Biol Med 30 (2001) 1243-1253
25. Perez M.J., and Cederbaum A.I. Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells. Hepatology 37 (2003) 1395-1404
26. Bardag-Gorce F., Yuan Q.X., Li J., et al. The effect of ethanol-induced cytochrome p4502E1 on the inhibition of proteasome activity by alcohol. Biochem Biophys Res Commun 279 (2000) 23-29
27. Osna N.A., Clemens D.L., and Donohue Jr. T.M. Ethanol metabolism alters interferon γ signaling in recombinant HepG2 cells. Hepatology 42 (2005) 1109-1117
28. Brychcy M., Kuckelkorn U., Hausdorf G., et al. Anti-20S proteasome autoantibodies inhibit proteasome stimulation by proteasome activator PA28. Arthritis Rheum 54 (2006) 2175-2183
29. Li J., Gao X., Ortega J., et al. Lysine 188 substitutions convert the pattern of proteasome activation by REG γ to that of REGs α and β. EMBO J 20 (2001) 3359-3369
30. Moriishi K., Okabayashi T., Nakai K., et al. Proteasome activator PA28γ-dependent nuclear retention and degradation of hepatitis C virus core protein. J Virol 77 (2003) 10237-10249
31. Lin W., Kim S.S., Yeung E., et al. Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain. J Virol 80 (2006) 9226-9235
32. Hosui A., Ohkawa K., Ishida H., et al. Hepatitis C virus core protein differently regulates the JAK-STAT signaling pathway under interleukin-6 and interferon-γ stimuli. J Biol Chem 278 (2003) 28562-28571
33. Goasduff T., and Cederbaum A.I. CYP2E1 degradation by in vitro reconstituted systems: role of the molecular chaperone hsp90. Arch Biochem Biophys 379 (2000) 321-330
34. Lu X., Michaud C., and Orlowski M. Heat shock protein-90 and the catalytic activities of the 20S proteasome (multicatalytic proteinase complex). Arch Biochem Biophys 387 (2001) 163-171
35. Minami Y., Kawasaki H., Minami M., et al. A critical role for the proteasome activator PA28 in the Hsp90-dependent protein refolding. J Biol Chem 275 (2000) 9055-9061
36. Munakata T., Liang Y., Kim S., et al. Hepatitis C virus induces E6AP-dependent degradation of the retinoblastoma protein. PLoS Pathog 3 (2007) 1335-1347
37. Lin W., Choe W.H., Hiasa Y., et al. Hepatitis C virus expression suppresses interferon signaling by degrading STAT1. Gastroenterology 128 (2005) 1034-1041
38. Hampson L., Kitchener H.C., and Hampson I.N. Specific HIV protease inhibitors inhibit the ability of HPV16 E6 to degrade p53 and selectively kill E6-dependent cervical carcinoma cells in vitro. Antivir Ther 11 (2006) 813-825