Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds

European Journal of Medicinal Chemistry

Volumn 41, Issue 5, 2006, Pages 577-585

  Das, Umashankar ^a   Gul, H Inci ^a,b   Alcorn, Jane ^a   Shrivastav, Anuraag ^c   George, Theresa ^c   Sharma, Rajendra K ^c   Nienaber, Kurt H ^c   De Clercq, Erik ^d   Balzarini, Jan ^d   Kawase, Masami ^e   Kan, Noriyuki ^e   Tanaka, Toru ^e   Tani, Satoru ^e   Werbovetz, Karl A ^f   Yakovich, Adam J ^f   Manavathu, Elias K ^g   Stables, James P ^h   Dimmock, Jonathan R ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b ATATÜRK UNIVERSITY   (Turkey)

^c UNIVERSITY OF SASKATCHEWAN   (Canada)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^e JOSAI UNIVERSITY   (Japan)

^f OHIO STATE UNIVERSITY   (United States)

^g WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Apoptosis; Conjugated unsaturated ketones; Cytotoxicity; Molecular modelling; Rodent toxicity; Structure activity relationships

Indexed keywords

1 (4 NITROPHENYLMETHYLENE) 2 OXO 2,3 DIHYDRO 1H INDENE; 5 ARYL 1 (4 NITROPHENYL) 3 OXO 1,4 PENTADIENE DERIVATIVE; 5 ARYLIDENE 2 (4 NITROPHENYLMETHYLENE)CYCLOPENTANONE DERIVATIVE; ALICYCLIC COMPOUND; CYTOTOXIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; T LYMPHOCYTE;

ALKADIENES; ANIMALS; CELL LINE; CELL PROLIFERATION; CYCLIZATION; HUMANS; MICE; MOLECULAR STRUCTURE; NITROPHENOLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646787786     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.12.014     Document Type: Article

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