Design, synthesis, and biological evaluation of hybrid molecules containing α-methylene-γ-butyrolactones and polypyrrole minor groove binders

Journal of Medicinal Chemistry

Volumn 47, Issue 11, 2004, Pages 2877-2886

  Baraldi, Pier Giovanni ^a   Del Carmen Nunez, Maria ^a   Tabrizi, Mojgan Aghazadeh ^a   De Clercq, Erik ^b   Balzarini, Jan ^b   Bermejo, Jaime ^c   Estévez, Francisco ^d   Romagnoli, Romeo ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c INSTITUTO DE PRODUCTOS NATURALES Y AGROBIOLOGÍA   (Spain)

^d UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA METHYLENE BUTYROLACTONE DERIVATIVE; ANTINEOPLASTIC AGENT; DISTAMYCIN A; DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLYPYRROLE; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CHROMATIN STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DNA METABOLISM; DNA STRUCTURE; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME DEGRADATION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HYBRID; HYDROLYSIS; IN VITRO STUDY; NONHUMAN;

4-BUTYROLACTONE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DNA FRAGMENTATION; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTROPHORESIS, AGAR GEL; HUMANS; HYDROLYSIS; MICE; MICROSCOPY, FLUORESCENCE; POLY(ADP-RIBOSE) POLYMERASES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2442645224     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm031104y     Document Type: Article

References (28)

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