Altered expression of nuclear receptors affects the expression of metabolic enzymes and transporters in a rat model of cholestasis

Biological and Pharmaceutical Bulletin

Volumn 32, Issue 12, 2009, Pages 2046-2052

  Hasegawa, Yoshitaka ^a   Kishimoto, Shuichi ^a   Takahashi, Hirokazu ^a   Inotsume, Nobuo ^b   Takeuchi, Yoshikazu ^a   Fukushima, Shoji ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Bile duct ligation; Cytochrome P450; Metabolic enzyme; Nuclear receptor; Transporter

Indexed keywords

BILIRUBIN; CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; CYTOCHROME P450 4A1; FATTY ACID; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 2B1; LIVER ENZYME; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SULFOTRANSFERASE 1A1; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BILE DUCT LIGATION; CELL NUCLEUS INCLUSION BODY; CHOLESTASIS; GENE CONTROL; GENE TARGETING; IN VIVO STUDY; LIVER METABOLISM; LIVER PROTECTION; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BILE DUCTS; BILIRUBIN; BLOTTING, WESTERN; CELL NUCLEUS; CHOLESTASIS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYMES; FATTY ACIDS; GENE EXPRESSION; LIVER; MEMBRANE TRANSPORT PROTEINS; MODELS, ANIMAL; PPAR ALPHA; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 73449093852     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.32.2046     Document Type: Article

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