Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine

Neuropharmacology

Volumn 58, Issue 3, 2010, Pages 640-649

  Leanne Lash Van Wyhe, L ^a,b   Postila, Pekka A ^c   Tsubone, Koichi ^d   Sasaki, Makoto ^d   Pentikäinen, Olli T ^c   Sakai, Ryuichi ^e   Swanson, Geoffrey T ^b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF JYVÄSKYLÄ   (Finland)

^d TOHOKU UNIVERSITY   (Japan)

^e HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Electrophysiology; Glutamate receptor; Ligand binding domain; Marine natural product; Radioligand binding; Synthetic

Indexed keywords

10 HYDROXYMETHYLNEODYSIHERBAINE A; 10 METHOXYMETHYLNEODYSIHERBAINE A; 8 DESMETHYL 10 HYDROXYMETHYLDYSIHERBAINE; AMPA RECEPTOR; DYSIHERBAINE; GLUTAMATE RECEPTOR 5; GLUTAMATE RECEPTOR 6; GLUTAMATE RECEPTOR 7; KAINIC ACID RECEPTOR; KAINIC ACID RECEPTOR AGONIST; MARINE TOXIN; NEODYSIHERBAINE A; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; RECEPTOR AFFINITY;

ALANINE; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING, COMPETITIVE; CELL LINE, TRANSFORMED; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; GLUTAMIC ACID; GREEN FLUORESCENT PROTEINS; HUMANS; KAINIC ACID; LIGANDS; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; RADIOLIGAND ASSAY; RECEPTORS, KAINIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TRANSFECTION; TRITIUM;

EID: 73449090753     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2009.11.013     Document Type: Article

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