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Volumn 119, Issue 18, 1997, Pages 4112-4116

Dysiherbaine: A new neurotoxic amino acid from the Micronesian marine sponge Dysidea herbacea

Author keywords

[No Author keywords available]

Indexed keywords

4 PHOSPHONOMETHYLPIPECOLIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; DIAMINO ACID; DICARBOXYLIC ACID; DOMOIC ACID; GLUTAMATE RECEPTOR; GLUTAMIC ACID; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROTOXIN;

EID: 0031004214     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja963953z     Document Type: Article
Times cited : (183)

References (36)
  • 11
    • 0001933593 scopus 로고
    • McGeer, E. G., Olney, J. W., Mcgeer, P. L., Eds.; Raven Press: New York
    • (a) Watkins, J. C. In Kainic Acid as a Tools in Neurobiology; McGeer, E. G., Olney, J. W., Mcgeer, P. L., Eds.; Raven Press: New York, 1978; pp 37-69.
    • (1978) Kainic Acid as a Tools in Neurobiology , pp. 37-69
    • Watkins, J.C.1
  • 14
    • 0009550706 scopus 로고
    • Note that a shift of 0.05 ppm was observed on C3, a methylene carbon. See: Jeremic, D.; Milosavljevic, M. Lj. Tetrahedron 1982, 38, 3325-3328.
    • (1982) Tetrahedron , vol.38 , pp. 3325-3328
    • Jeremic, D.1    Milosavljevic, M.Lj.2
  • 15
    • 1842414662 scopus 로고    scopus 로고
    • note
    • CH of 10 and 5 Hz were performed.
  • 16
    • 1842373138 scopus 로고    scopus 로고
    • note
    • Treatment of 1 with diazomethane gave a complicated mixture. Acetylations of 1 with pyridine-acetic anhydride or acetic acid-acetic anhydride were both unsuccessful.
  • 17
    • 1842333118 scopus 로고    scopus 로고
    • note
    • 1H NMR spectrum in the δ 3.85 region. H2 and H3b was also separated into two sets. This may be due to partial racemization at C2 during the reaction.
  • 18
    • 0028820294 scopus 로고
    • C,H were successfully demonstrated by the following: (a) Matsumori, N.; Murata, M.; Tachibana, K. Tetrahedron 1995, 51, 12229-12238. (b) Matsumori, N.; Nonomura, T.; Sasaki, M.; Tachibana, K.; Satake, M.; Yasumoto, T. Tetrahedron Lett. 1996, 37, 1269-1272.
    • (1995) Tetrahedron , vol.51 , pp. 12229-12238
    • Matsumori, N.1    Murata, M.2    Tachibana, K.3
  • 26
    • 0000474256 scopus 로고
    • C,H can be calculated from the relative intensity of a crosspeak in the PS-HMBC spectrum and that in the reference spectrum; see ref 11a and the following: (a) Zhu, G.; Bax, A. J. Magn. Reson. 1993, 104A, 353-357. (b) Zhu, G.; Live, D.; Bax, A. J. Am. Chem. Soc. 1994, 116, 8370-8371.
    • (1993) J. Magn. Reson. , vol.104 A , pp. 353-357
    • Zhu, G.1    Bax, A.2
  • 27
    • 0028045353 scopus 로고
    • C,H can be calculated from the relative intensity of a crosspeak in the PS-HMBC spectrum and that in the reference spectrum; see ref 11a and the following: (a) Zhu, G.; Bax, A. J. Magn. Reson. 1993, 104A, 353-357. (b) Zhu, G.; Live, D.; Bax, A. J. Am. Chem. Soc. 1994, 116, 8370-8371.
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 8370-8371
    • Zhu, G.1    Live, D.2    Bax, A.3
  • 28
    • 1842374270 scopus 로고    scopus 로고
    • note
    • C,H values should have an intermediate value.
  • 29
    • 1842299136 scopus 로고    scopus 로고
    • note
    • 2J(H3-C2) as a reference value.
  • 31
    • 1842327847 scopus 로고    scopus 로고
    • note
    • 3H]AMPA was inhibited by AMPA (5.6 ± 1.1) or Glu (124 ± 41).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.