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Volumn 183, Issue 11, 2009, Pages 7326-7336

Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2D; INTERLEUKIN DERIVATIVE;

EID: 73349115244     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902697     Document Type: Article
Times cited : (17)

References (56)
  • 3
    • 42649134105 scopus 로고    scopus 로고
    • Interleukin-21: Basic biology and implications for cancer and autoimmunity
    • DOI 10.1146/annurev.immunol.26.021607.090316
    • Spolski, R., and W. J. Leonard. 2008. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol. 26: 57-79. (Pubitemid 351600371)
    • (2008) Annual Review of Immunology , vol.26 , pp. 57-79
    • Spolski, R.1    Leonard, W.J.2
  • 4
    • 25444434157 scopus 로고    scopus 로고
    • Interleukin-21: A modulator of lymphoid proliferation, apoptosis and differentiation
    • DOI 10.1038/nri1688, PII NRI1688
    • Leonard, W. J., and R. Spolski. 2005. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat. Rev. Immunol. 5: 688-698. (Pubitemid 43086171)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.9 , pp. 688-698
    • Leonard, W.J.1    Spolski, R.2
  • 8
    • 22344451592 scopus 로고    scopus 로고
    • Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer
    • Smyth, M. J., M. E. Wallace, S. L. Nutt, H. Yagita, D. I. Godfrey, and Y. Hayakawa. 2005. Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer. J. Exp. Med. 201: 1973-1985.
    • (2005) J. Exp. Med. , vol.201 , pp. 1973-1985
    • Smyth, M.J.1    Wallace, M.E.2    Nutt, S.L.3    Yagita, H.4    Godfrey, D.I.5    Hayakawa, Y.6
  • 9
    • 2542595794 scopus 로고    scopus 로고
    • + T cell responses to achieve durable tumor immunity: Comparative evaluation of IL-2, IL-15, and IL-21
    • + T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21. J. Immunol. 173: 900-909.
    • (2004) J. Immunol. , vol.173 , pp. 900-909
    • Moroz, A.1    Eppolito, C.2    Li, Q.3    Tao, J.4    Clegg, C.H.5    Shrikant, P.A.6
  • 14
    • 0038784488 scopus 로고    scopus 로고
    • IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-γ
    • Ma, H. L., M. J. Whitters, R. F. Konz, M. Senices, D. A. Young, M. J. Grusby, M. Collins, and K. Dunussi-Joannopoulos. 2003. IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-γ. J. Immunol. 171: 608-615.
    • (2003) J. Immunol. , vol.171 , pp. 608-615
    • Ma, H.L.1    Whitters, M.J.2    Konz, R.F.3    Senices, M.4    Young, D.A.5    Grusby, M.J.6    Collins, M.7    Dunussi-Joannopoulos, K.8
  • 16
    • 18344394955 scopus 로고    scopus 로고
    • IL-21 limits NK cell responses and promotes antigen-specific T cell activation: A mediator of the transition from innate to adaptive immunity
    • Kasaian, M. T., M. J. Whitters, L. L. Carter, L. D. Lowe, J. M. Jussif, B. Deng, K. A. Johnson, J. S. Witek, M. Senices, R. F. Konz, et al. 2002. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity 16: 559-569.
    • (2002) Immunity , vol.16 , pp. 559-569
    • Kasaian, M.T.1    Whitters, M.J.2    Carter, L.L.3    Lowe, L.D.4    Jussif, J.M.5    Deng, B.6    Johnson, K.A.7    Witek, J.S.8    Senices, M.9    Konz, R.F.10
  • 17
    • 31644448692 scopus 로고    scopus 로고
    • Interleukin-21 triggers both cellular and humoral immune responses leading to therapeutic antitumor effects against head and neck squamous cell carcinoma
    • Nakano, H., T. Kishida, H. Asada, M. Shin-Ya, T. Shinomiya, J. Imanishi, T. Shimada, S. Nakai, M. Takeuchi, Y. Hisa, and O. Mazda. 2006. Interleukin-21 triggers both cellular and humoral immune responses leading to therapeutic antitumor effects against head and neck squamous cell carcinoma. J. Gene Med. 8: 90-99.
    • (2006) J. Gene Med. , vol.8 , pp. 90-99
    • Nakano, H.1    Kishida, T.2    Asada, H.3    Shin-Ya, M.4    Shinomiya, T.5    Imanishi, J.6    Shimada, T.7    Nakai, S.8    Takeuchi, M.9    Hisa, Y.10    Mazda, O.11
  • 18
    • 34548681848 scopus 로고    scopus 로고
    • Glioma immunotherapy by IL-21 gene-modified cells or by recombinant IL-21 involves antibody responses
    • Daga, A., A. M. Orengo, R. M. Gangemi, D. Marubbi, M. Perera, A. Comes, S. Ferrini, and G. Corte. 2007. Glioma immunotherapy by IL-21 gene-modified cells or by recombinant IL-21 involves antibody responses. Int. J. Cancer 121: 1756-1763.
    • (2007) Int. J. Cancer , vol.121 , pp. 1756-1763
    • Daga, A.1    Orengo, A.M.2    Gangemi, R.M.3    Marubbi, D.4    Perera, M.5    Comes, A.6    Ferrini, S.7    Corte, G.8
  • 19
  • 21
    • 63449095686 scopus 로고    scopus 로고
    • Clinical and biological efficacy of recombinant human interleukin-21 in patients with stage IV malignant melanoma without prior treatment: A phase IIa trial
    • Davis, I. D., B. Brady, R. F. Kefford, M. Millward, J. Cebon, B. K. Skrumsager, U. Mouritzen, L. T. Hansen, K. Skak, D. Lundsgaard, et al. 2009. Clinical and biological efficacy of recombinant human interleukin-21 in patients with stage IV malignant melanoma without prior treatment: a phase IIa trial. Clin. Cancer Res. 15: 2123-2129.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 2123-2129
    • Davis, I.D.1    Brady, B.2    Kefford, R.F.3    Millward, M.4    Cebon, J.5    Skrumsager, B.K.6    Mouritzen, U.7    Hansen, L.T.8    Skak, K.9    Lundsgaard, D.10
  • 25
    • 52949091915 scopus 로고    scopus 로고
    • IL-21 signaling is critical for the development of type I diabetes in the NOD mouse
    • Spolski, R., M. Kashyap, C. Robinson, Z. Yu, and W. J. Leonard. 2008. IL-21 signaling is critical for the development of type I diabetes in the NOD mouse. Proc. Natl. Acad. Sci. USA 105: 14028-14033.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 14028-14033
    • Spolski, R.1    Kashyap, M.2    Robinson, C.3    Yu, Z.4    Leonard, W.J.5
  • 31
    • 0036645278 scopus 로고    scopus 로고
    • A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas
    • Crowe, N. Y., M. J. Smyth, and D. I. Godfrey. 2002. A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas. J. Exp. Med. 196: 119-127.
    • (2002) J. Exp. Med. , vol.196 , pp. 119-127
    • Crowe, N.Y.1    Smyth, M.J.2    Godfrey, D.I.3
  • 32
    • 34248193253 scopus 로고    scopus 로고
    • Immune surveillance of tumors
    • Swann, J. B., and M. J. Smyth. 2007. Immune surveillance of tumors. J. Clin. Invest. 117: 1137-1146.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1137-1146
    • Swann, J.B.1    Smyth, M.J.2
  • 33
    • 0842278642 scopus 로고    scopus 로고
    • IL-21 induces the functional maturation of murine NK cells
    • Brady, J., Y. Hayakawa, M. J. Smyth, and S. L. Nutt. 2004. IL-21 induces the functional maturation of murine NK cells. J. Immunol. 172: 2048-2058.
    • (2004) J. Immunol. , vol.172 , pp. 2048-2058
    • Brady, J.1    Hayakawa, Y.2    Smyth, M.J.3    Nutt, S.L.4
  • 34
    • 0022616253 scopus 로고
    • Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy
    • Karre, K., H. G. Ljunggren, G. Piontek, and R. Kiessling. 1986. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 319: 675-678.
    • (1986) Nature , vol.319 , pp. 675-678
    • Karre, K.1    Ljunggren, H.G.2    Piontek, G.3    Kiessling, R.4
  • 35
    • 0037111464 scopus 로고    scopus 로고
    • Cutting edge: Tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin
    • Hayakawa, Y., J. M. Kelly, J. A. Westwood, P. K. Darcy, A. Diefenbach, D. Raulet, and M. J. Smyth. 2002. Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin. J. Immunol. 169: 5377-5381.
    • (2002) J. Immunol. , vol.169 , pp. 5377-5381
    • Hayakawa, Y.1    Kelly, J.M.2    Westwood, J.A.3    Darcy, P.K.4    Diefenbach, A.5    Raulet, D.6    Smyth, M.J.7
  • 36
    • 0032729476 scopus 로고    scopus 로고
    • Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells
    • Carnaud, C., D. Lee, O. Donnars, S. H. Park, A. Beavis, Y. Koezuka, and A. Bendelac. 1999. Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J. Immunol. 163: 4647-4650.
    • (1999) J. Immunol. , vol.163 , pp. 4647-4650
    • Carnaud, C.1    Lee, D.2    Donnars, O.3    Park, S.H.4    Beavis, A.5    Koezuka, Y.6    Bendelac, A.7
  • 37
    • 33847369755 scopus 로고    scopus 로고
    • Tumor cells loaded with α-galactosylceramide induce innate NKT and NK cell-dependent resistance to tumor implantation in mice
    • Shimizu, K., A. Goto, M. Fukui, M. Taniguchi, and S. Fujii. 2007. Tumor cells loaded with α-galactosylceramide induce innate NKT and NK cell-dependent resistance to tumor implantation in mice. J. Immunol. 178: 2853-2861.
    • (2007) J. Immunol. , vol.178 , pp. 2853-2861
    • Shimizu, K.1    Goto, A.2    Fukui, M.3    Taniguchi, M.4    Fujii, S.5
  • 38
    • 0033854136 scopus 로고    scopus 로고
    • The interface between innate and acquired immunity: Glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes
    • Nishimura, T., H. Kitamura, K. Iwakabe, T. Yahata, A. Ohta, M. Sato, K. Takeda, K. Okumura, K. L. Van, T. Kawano, et al. 2000. The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes. Int. Immunol. 12: 987-994.
    • (2000) Int. Immunol. , vol.12 , pp. 987-994
    • Nishimura, T.1    Kitamura, H.2    Iwakabe, K.3    Yahata, T.4    Ohta, A.5    Sato, M.6    Takeda, K.7    Okumura, K.8    Van, K.L.9    Kawano, T.10
  • 41
    • 46749156754 scopus 로고    scopus 로고
    • Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis
    • Coquet, J. M., S. Chakravarti, M. J. Smyth, and D. I. Godfrey. 2008. Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. J. Immunol. 180: 7097-7101.
    • (2008) J. Immunol. , vol.180 , pp. 7097-7101
    • Coquet, J.M.1    Chakravarti, S.2    Smyth, M.J.3    Godfrey, D.I.4
  • 43
    • 0035165729 scopus 로고    scopus 로고
    • Perforin and interferon-γ activities independently control tumor initiation, growth, and metastasis
    • Street, S. E., E. Cretney, and M. J. Smyth. 2001. Perforin and interferon-γ activities independently control tumor initiation, growth, and metastasis. Blood 97: 192-197.
    • (2001) Blood , vol.97 , pp. 192-197
    • Street, S.E.1    Cretney, E.2    Smyth, M.J.3
  • 44
    • 0035071525 scopus 로고    scopus 로고
    • NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma
    • Smyth, M. J., N. Y. Crowe, and D. I. Godfrey. 2001. NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma. Int. Immunol. 13: 459-463.
    • (2001) Int. Immunol. , vol.13 , pp. 459-463
    • Smyth, M.J.1    Crowe, N.Y.2    Godfrey, D.I.3
  • 45
    • 0034970326 scopus 로고    scopus 로고
    • Critical contribution of IFN-γ and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of α-galactosylceramide
    • Hayakawa, Y., K. Takeda, H. Yagita, S. Kakuta, Y. Iwakura, K. L. Van, I. Saiki, and K. Okumura. 2001. Critical contribution of IFN-γ and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of α-galactosylceramide. Eur. J. Immunol. 31: 1720-1727.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1720-1727
    • Hayakawa, Y.1    Takeda, K.2    Yagita, H.3    Kakuta, S.4    Iwakura, Y.5    Van, K.L.6    Saiki, I.7    Okumura, K.8
  • 46
    • 34250173393 scopus 로고    scopus 로고
    • IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype
    • Casey, K. A., and M. F. Mescher. 2007. IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype. J. Immunol. 178: 7640-7648.
    • (2007) J. Immunol. , vol.178 , pp. 7640-7648
    • Casey, K.A.1    Mescher, M.F.2
  • 47
    • 39549101010 scopus 로고    scopus 로고
    • Interleukin-21 activates human natural killer cells and modulates their surface receptor expression
    • Skak, K., K. S. Frederiksen, and D. Lundsgaard. 2008. Interleukin-21 activates human natural killer cells and modulates their surface receptor expression. Immunology 123: 575-583.
    • (2008) Immunology , vol.123 , pp. 575-583
    • Skak, K.1    Frederiksen, K.S.2    Lundsgaard, D.3
  • 48
    • 34848927882 scopus 로고    scopus 로고
    • IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cells
    • Liu, S., G. Lizee, Y. Lou, C. Liu, W. W. Overwijk, G. Wang, and P. Hwu. 2007. IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cells. Int. Immunol. 19: 1213-1221.
    • (2007) Int. Immunol. , vol.19 , pp. 1213-1221
    • Liu, S.1    Lizee, G.2    Lou, Y.3    Liu, C.4    Overwijk, W.W.5    Wang, G.6    Hwu, P.7
  • 49
    • 0346993779 scopus 로고    scopus 로고
    • Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo
    • Brandt, K., S. Bulfone-Paus, A. Jenckel, D. C. Foster, R. Paus, and R. Ruckert. 2003. Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo. J. Invest. Dermatol. 121: 1379-1382.
    • (2003) J. Invest. Dermatol. , vol.121 , pp. 1379-1382
    • Brandt, K.1    Bulfone-Paus, S.2    Jenckel, A.3    Foster, D.C.4    Paus, R.5    Ruckert, R.6
  • 50
    • 0345257344 scopus 로고    scopus 로고
    • Interleukin-21 inhibits dendritic cell activation and maturation
    • Brandt, K., S. Bulfone-Paus, D. C. Foster, and R. Ruckert. 2003. Interleukin-21 inhibits dendritic cell activation and maturation. Blood 102: 4090-4098.
    • (2003) Blood , vol.102 , pp. 4090-4098
    • Brandt, K.1    Bulfone-Paus, S.2    Foster, D.C.3    Ruckert, R.4
  • 51
    • 67649203681 scopus 로고    scopus 로고
    • A vital role for interleukin-21 in the control of a chronic viral infection
    • Yi, J. S., M. Du, and A. J. Zajac. 2009. A vital role for interleukin-21 in the control of a chronic viral infection. Science 324: 1572-1576.
    • (2009) Science , vol.324 , pp. 1572-1576
    • Yi, J.S.1    Du, M.2    Zajac, A.J.3
  • 52
    • 67649217469 scopus 로고    scopus 로고
    • IL-21 is required to control chronic viral infection
    • Elsaesser, H., K. Sauer, and D. G. Brooks. 2009. IL-21 is required to control chronic viral infection. Science 324: 1569-1572.
    • (2009) Science , vol.324 , pp. 1569-1572
    • Elsaesser, H.1    Sauer, K.2    Brooks, D.G.3
  • 55
    • 64849083153 scopus 로고    scopus 로고
    • IL-21 mediates suppressive effects via its induction of IL-10
    • Spolski, R., H. P. Kim, W. Zhu, D. E. Levy, and W. J. Leonard. 2009. IL-21 mediates suppressive effects via its induction of IL-10. J. Immunol. 182: 2859-2867.
    • (2009) J. Immunol. , vol.182 , pp. 2859-2867
    • Spolski, R.1    Kim, H.P.2    Zhu, W.3    Levy, D.E.4    Leonard, W.J.5
  • 56
    • 70350114258 scopus 로고    scopus 로고
    • Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism
    • Gelebart, P., Z. Zak, M. Anand, J. en-Bard, H. M. Amin, and R. Lai. 2009. Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism. Leukemia 23: 1836-1846.
    • (2009) Leukemia , vol.23 , pp. 1836-1846
    • Gelebart, P.1    Zak, Z.2    Anand, M.3    En-Bard, J.4    Amin, H.M.5    Lai, R.6


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