-
1
-
-
0034597789
-
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
-
Parrish-Novak, J., S. R. Dillon, A. Nelson, A. Hammond, C. Sprecher, J. A. Gross, J. Johnston, K. Madden, W. Xu, J. West, et al. 2000. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408: 57-63.
-
(2000)
Nature
, vol.408
, pp. 57-63
-
-
Parrish-Novak, J.1
Dillon, S.R.2
Nelson, A.3
Hammond, A.4
Sprecher, C.5
Gross, J.A.6
Johnston, J.7
Madden, K.8
Xu, W.9
West, J.10
-
2
-
-
33847367120
-
IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production
-
Coquet, J. M., K. Kyparissoudis, D. G. Pellicci, G. Besra, S. P. Berzins, M. J. Smyth, and D. I. Godfrey. 2007. IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J. Immunol. 178: 2827-2834. (Pubitemid 46333160)
-
(2007)
Journal of Immunology
, vol.178
, Issue.5
, pp. 2827-2834
-
-
Coquet, J.M.1
Kyparissoudis, K.2
Pellicci, D.G.3
Besra, G.4
Berzins, S.P.5
Smyth, M.J.6
Godfrey, D.I.7
-
3
-
-
42649134105
-
Interleukin-21: Basic biology and implications for cancer and autoimmunity
-
DOI 10.1146/annurev.immunol.26.021607.090316
-
Spolski, R., and W. J. Leonard. 2008. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol. 26: 57-79. (Pubitemid 351600371)
-
(2008)
Annual Review of Immunology
, vol.26
, pp. 57-79
-
-
Spolski, R.1
Leonard, W.J.2
-
4
-
-
25444434157
-
Interleukin-21: A modulator of lymphoid proliferation, apoptosis and differentiation
-
DOI 10.1038/nri1688, PII NRI1688
-
Leonard, W. J., and R. Spolski. 2005. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat. Rev. Immunol. 5: 688-698. (Pubitemid 43086171)
-
(2005)
Nature Reviews Immunology
, vol.5
, Issue.9
, pp. 688-698
-
-
Leonard, W.J.1
Spolski, R.2
-
5
-
-
40049093723
-
Interleukin 21: Combination strategies for cancer therapy
-
Skak, K., M. Kragh, D. Hausman, M. J. Smyth, and P. V. Sivakumar. 2008. Interleukin 21: combination strategies for cancer therapy. Nat. Rev. Drug Discov. 7: 231-240.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 231-240
-
-
Skak, K.1
Kragh, M.2
Hausman, D.3
Smyth, M.J.4
Sivakumar, P.V.5
-
6
-
-
0347320749
-
In Vivo Antitumor Activity of Interleukin 21 Mediated by Natural Killer Cells
-
Wang, G., M. Tschoi, R. Spolski, Y. Lou, K. Ozaki, C. Feng, G. Kim, W. J. Leonard, and P. Hwu. 2003. In vivo antitumor activity of interleukin 21 mediated by natural killer cells. Cancer Res. 63: 9016-9022. (Pubitemid 38064083)
-
(2003)
Cancer Research
, vol.63
, Issue.24
, pp. 9016-9022
-
-
Wang, G.1
Tschoi, M.2
Spolski, R.3
Lou, Y.4
Ozaki, K.5
Feng, C.6
Kim, G.7
Leonard, W.J.8
Hwu, P.9
-
7
-
-
23444459564
-
IL-21 enhances tumor rejection through a NKG2D-dependent mechanism
-
Takaki, R., Y. Hayakawa, A. Nelson, P. V. Sivakumar, S. Hughes, M. J. Smyth, and L. L. Lanier. 2005. IL-21 enhances tumor rejection through a NKG2D-dependent mechanism. J. Immunol. 175: 2167-2173. (Pubitemid 41113822)
-
(2005)
Journal of Immunology
, vol.175
, Issue.4
, pp. 2167-2173
-
-
Takaki, R.1
Hayakawa, Y.2
Nelson, A.3
Sivakumar, P.V.4
Hughes, S.5
Smyth, M.J.6
Lanier, L.L.7
-
8
-
-
22344451592
-
Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer
-
Smyth, M. J., M. E. Wallace, S. L. Nutt, H. Yagita, D. I. Godfrey, and Y. Hayakawa. 2005. Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer. J. Exp. Med. 201: 1973-1985.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 1973-1985
-
-
Smyth, M.J.1
Wallace, M.E.2
Nutt, S.L.3
Yagita, H.4
Godfrey, D.I.5
Hayakawa, Y.6
-
9
-
-
2542595794
-
+ T cell responses to achieve durable tumor immunity: Comparative evaluation of IL-2, IL-15, and IL-21
-
+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21. J. Immunol. 173: 900-909.
-
(2004)
J. Immunol.
, vol.173
, pp. 900-909
-
-
Moroz, A.1
Eppolito, C.2
Li, Q.3
Tao, J.4
Clegg, C.H.5
Shrikant, P.A.6
-
10
-
-
34347387967
-
+ T cells and inhibits the growth of syngeneic tumors
-
+ T cells and inhibits the growth of syngeneic tumors. Cancer Immunol. Immunother. 56: 1417-1428.
-
(2007)
Cancer Immunol. Immunother.
, vol.56
, pp. 1417-1428
-
-
Sondergaard, H.1
Frederiksen, K.S.2
Thygesen, P.3
Galsgaard, E.D.4
Skak, K.5
Kristjansen, P.E.6
Odum, N.7
Kragh, M.8
-
11
-
-
19944434230
-
+ T cell expansion and function
-
+ T cell expansion and function. J. Exp. Med. 201: 139-148.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 139-148
-
-
Zeng, R.1
Spolski, R.2
Finkelstein, S.E.3
Oh, S.4
Kovanen, P.E.5
Hinrichs, C.S.6
Pise-Masison, C.A.7
Radonovich, M.F.8
Brady, J.N.9
Restifo, N.P.10
-
12
-
-
31144434868
-
+ regulatory T cell depletion augments immunotherapy of micrometastases by an IL-21-secreting cellular vaccine
-
+ regulatory T cell depletion augments immunotherapy of micrometastases by an IL-21-secreting cellular vaccine. J. Immunol. 176: 1750-1758.
-
(2006)
J. Immunol.
, vol.176
, pp. 1750-1758
-
-
Comes, A.1
Rosso, O.2
Orengo, A.M.3
Di Carlo, E.4
Sorrentino, C.5
Meazza, R.6
Piazza, T.7
Valzasina, B.8
Nanni, P.9
Colombo, M.P.10
Ferrini, S.11
-
13
-
-
1642444178
-
IL-21 Induces Tumor Rejection by Specific CTL and IFN-γ-Dependent CXC Chemokines in Syngeneic Mice
-
Di Carlo, E., A. Comes, A. M. Orengo, O. Rosso, R. Meazza, P. Musiani, M. P. Colombo, and S. Ferrini. 2004. IL-21 induces tumor rejection by specific CTL and IFN-γ-dependent CXC chemokines in syngeneic mice. J. Immunol. 172: 1540-1547. (Pubitemid 38116798)
-
(2004)
Journal of Immunology
, vol.172
, Issue.3
, pp. 1540-1547
-
-
Di Carlo, E.1
Comes, A.2
Orengo, A.M.3
Rosso, O.4
Meazza, R.5
Musiani, P.6
Colombo, M.P.7
Ferrini, S.8
-
14
-
-
0038784488
-
IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-γ
-
Ma, H. L., M. J. Whitters, R. F. Konz, M. Senices, D. A. Young, M. J. Grusby, M. Collins, and K. Dunussi-Joannopoulos. 2003. IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-γ. J. Immunol. 171: 608-615.
-
(2003)
J. Immunol.
, vol.171
, pp. 608-615
-
-
Ma, H.L.1
Whitters, M.J.2
Konz, R.F.3
Senices, M.4
Young, D.A.5
Grusby, M.J.6
Collins, M.7
Dunussi-Joannopoulos, K.8
-
16
-
-
18344394955
-
IL-21 limits NK cell responses and promotes antigen-specific T cell activation: A mediator of the transition from innate to adaptive immunity
-
Kasaian, M. T., M. J. Whitters, L. L. Carter, L. D. Lowe, J. M. Jussif, B. Deng, K. A. Johnson, J. S. Witek, M. Senices, R. F. Konz, et al. 2002. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity 16: 559-569.
-
(2002)
Immunity
, vol.16
, pp. 559-569
-
-
Kasaian, M.T.1
Whitters, M.J.2
Carter, L.L.3
Lowe, L.D.4
Jussif, J.M.5
Deng, B.6
Johnson, K.A.7
Witek, J.S.8
Senices, M.9
Konz, R.F.10
-
17
-
-
31644448692
-
Interleukin-21 triggers both cellular and humoral immune responses leading to therapeutic antitumor effects against head and neck squamous cell carcinoma
-
Nakano, H., T. Kishida, H. Asada, M. Shin-Ya, T. Shinomiya, J. Imanishi, T. Shimada, S. Nakai, M. Takeuchi, Y. Hisa, and O. Mazda. 2006. Interleukin-21 triggers both cellular and humoral immune responses leading to therapeutic antitumor effects against head and neck squamous cell carcinoma. J. Gene Med. 8: 90-99.
-
(2006)
J. Gene Med.
, vol.8
, pp. 90-99
-
-
Nakano, H.1
Kishida, T.2
Asada, H.3
Shin-Ya, M.4
Shinomiya, T.5
Imanishi, J.6
Shimada, T.7
Nakai, S.8
Takeuchi, M.9
Hisa, Y.10
Mazda, O.11
-
18
-
-
34548681848
-
Glioma immunotherapy by IL-21 gene-modified cells or by recombinant IL-21 involves antibody responses
-
Daga, A., A. M. Orengo, R. M. Gangemi, D. Marubbi, M. Perera, A. Comes, S. Ferrini, and G. Corte. 2007. Glioma immunotherapy by IL-21 gene-modified cells or by recombinant IL-21 involves antibody responses. Int. J. Cancer 121: 1756-1763.
-
(2007)
Int. J. Cancer
, vol.121
, pp. 1756-1763
-
-
Daga, A.1
Orengo, A.M.2
Gangemi, R.M.3
Marubbi, D.4
Perera, M.5
Comes, A.6
Ferrini, S.7
Corte, G.8
-
19
-
-
34547156550
-
IL-21 enhances dendritic cell ability to induce interferon-γ production by natural killer T cells
-
Maeda, M., Y. Yanagawa, K. Iwabuchi, K. Minami, Y. Nakamaru, D. Takagi, S. Fukuda, and K. Onoe. 2007. IL-21 enhances dendritic cell ability to induce interferon-γ production by natural killer T cells. Immunobiology 212: 537-547.
-
(2007)
Immunobiology
, vol.212
, pp. 537-547
-
-
Maeda, M.1
Yanagawa, Y.2
Iwabuchi, K.3
Minami, K.4
Nakamaru, Y.5
Takagi, D.6
Fukuda, S.7
Onoe, K.8
-
20
-
-
34250761481
-
An open-label, two-arm, phase I trial of recombinant human interleukin-21 in patients with metastatic melanoma
-
Davis, I. D., B. K. Skrumsager, J. Cebon, T. Nicholaou, J. W. Barlow, N. P. Moller, K. Skak, D. Lundsgaard, K. S. Frederiksen, P. Thygesen, and G. A. McArthur. 2007. An open-label, two-arm, phase I trial of recombinant human interleukin-21 in patients with metastatic melanoma. Clin. Cancer Res. 13: 3630-3636.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 3630-3636
-
-
Davis, I.D.1
Skrumsager, B.K.2
Cebon, J.3
Nicholaou, T.4
Barlow, J.W.5
Moller, N.P.6
Skak, K.7
Lundsgaard, D.8
Frederiksen, K.S.9
Thygesen, P.10
McArthur, G.A.11
-
21
-
-
63449095686
-
Clinical and biological efficacy of recombinant human interleukin-21 in patients with stage IV malignant melanoma without prior treatment: A phase IIa trial
-
Davis, I. D., B. Brady, R. F. Kefford, M. Millward, J. Cebon, B. K. Skrumsager, U. Mouritzen, L. T. Hansen, K. Skak, D. Lundsgaard, et al. 2009. Clinical and biological efficacy of recombinant human interleukin-21 in patients with stage IV malignant melanoma without prior treatment: a phase IIa trial. Clin. Cancer Res. 15: 2123-2129.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 2123-2129
-
-
Davis, I.D.1
Brady, B.2
Kefford, R.F.3
Millward, M.4
Cebon, J.5
Skrumsager, B.K.6
Mouritzen, U.7
Hansen, L.T.8
Skak, K.9
Lundsgaard, D.10
-
22
-
-
48149096869
-
+ T cells in patients with metastatic melanoma and renal cell carcinoma
-
+ T cells in patients with metastatic melanoma and renal cell carcinoma. Cancer Immunol. Immunother. 57: 1439-1449.
-
(2008)
Cancer Immunol. Immunother.
, vol.57
, pp. 1439-1449
-
-
Frederiksen, K.S.1
Lundsgaard, D.2
Freeman, J.A.3
Hughes, S.D.4
Holm, T.L.5
Skrumsager, B.K.6
Petri, A.7
Hansen, L.T.8
McArthur, G.A.9
Davis, I.D.10
Skak, K.11
-
23
-
-
60849107595
-
A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice
-
Bubier, J. A., T. J. Sproule, O. Foreman, R. Spolski, D. J. Shaffer, H. C. Morse, III, W. J. Leonard, and D. C. Roopenian. 2009. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc. Natl. Acad. Sci. USA 106: 1518-1523.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 1518-1523
-
-
Bubier, J.A.1
Sproule, T.J.2
Foreman, O.3
Spolski, R.4
Shaffer, D.J.5
Morse III, H.C.6
Leonard, W.J.7
Roopenian, D.C.8
-
25
-
-
52949091915
-
IL-21 signaling is critical for the development of type I diabetes in the NOD mouse
-
Spolski, R., M. Kashyap, C. Robinson, Z. Yu, and W. J. Leonard. 2008. IL-21 signaling is critical for the development of type I diabetes in the NOD mouse. Proc. Natl. Acad. Sci. USA 105: 14028-14033.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 14028-14033
-
-
Spolski, R.1
Kashyap, M.2
Robinson, C.3
Yu, Z.4
Leonard, W.J.5
-
26
-
-
34247257447
-
Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
-
Young, D. A., M. Hegen, H. L. Ma, M. J. Whitters, L. M. Albert, L. Lowe, M. Senices, P. W. Wu, B. Sibley, Y. Leathurby, T. P. Brown, C. Nickerson-Nutter, J. C. Keith, Jr., and M. Collins. 2007. Blockade of the interleukin-21/ interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis. Arthritis Rheum. 56: 1152-1163.
-
(2007)
Arthritis Rheum.
, vol.56
, pp. 1152-1163
-
-
Young, D.A.1
Hegen, M.2
Ma, H.L.3
Whitters, M.J.4
Albert, L.M.5
Lowe, L.6
Senices, M.7
Wu, P.W.8
Sibley, B.9
Leathurby, Y.10
Brown, T.P.11
Nickerson-Nutter, C.12
Keith Jr., J.C.13
Collins, M.14
-
27
-
-
41349121555
-
Regulation of gut inflammation and th17 cell response by interleukin-21
-
Fina, D., M. Sarra, M. C. Fantini, A. Rizzo, R. Caruso, F. Caprioli, C. Stolfi, I. Cardolini, M. Dottori, M. Boirivant, F. Pallone, T. T. MacDonald, and G. Monteleone. 2008. Regulation of gut inflammation and th17 cell response by interleukin-21. Gastroenterology 134: 1038-1048.
-
(2008)
Gastroenterology
, vol.134
, pp. 1038-1048
-
-
Fina, D.1
Sarra, M.2
Fantini, M.C.3
Rizzo, A.4
Caruso, R.5
Caprioli, F.6
Stolfi, C.7
Cardolini, I.8
Dottori, M.9
Boirivant, M.10
Pallone, F.11
MacDonald, T.T.12
Monteleone, G.13
-
28
-
-
59649095271
-
DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors
-
Gilfillan, S., C. J. Chan, M. Cella, N. M. Haynes, A. S. Rapaport, K. S. Boles, D. M. Andrews, M. J. Smyth, and M. Colonna. 2008. DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors. J. Exp. Med. 205: 2965-2973.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2965-2973
-
-
Gilfillan, S.1
Chan, C.J.2
Cella, M.3
Haynes, N.M.4
Rapaport, A.S.5
Boles, K.S.6
Andrews, D.M.7
Smyth, M.J.8
Colonna, M.9
-
29
-
-
0037082487
-
+ T cells and natural killer cells is essential for the antimetastatic effect of α-galactosylceramide
-
+ T cells and natural killer cells is essential for the antimetastatic effect of α-galactosylceramide. Blood 99: 1259-1266.
-
(2002)
Blood
, vol.99
, pp. 1259-1266
-
-
Smyth, M.J.1
Crowe, N.Y.2
Pellicci, D.G.3
Kyparissoudis, K.4
Kelly, J.M.5
Takeda, K.6
Yagita, H.7
Godfrey, D.I.8
-
30
-
-
38649087921
-
Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis
-
Swann, J. B., M. D. Vesely, A. Silva, J. Sharkey, S. Akira, R. D. Schreiber, and M. J. Smyth. 2008. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc. Natl. Acad. Sci. USA 105: 652-656.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 652-656
-
-
Swann, J.B.1
Vesely, M.D.2
Silva, A.3
Sharkey, J.4
Akira, S.5
Schreiber, R.D.6
Smyth, M.J.7
-
31
-
-
0036645278
-
A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas
-
Crowe, N. Y., M. J. Smyth, and D. I. Godfrey. 2002. A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas. J. Exp. Med. 196: 119-127.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 119-127
-
-
Crowe, N.Y.1
Smyth, M.J.2
Godfrey, D.I.3
-
32
-
-
34248193253
-
Immune surveillance of tumors
-
Swann, J. B., and M. J. Smyth. 2007. Immune surveillance of tumors. J. Clin. Invest. 117: 1137-1146.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1137-1146
-
-
Swann, J.B.1
Smyth, M.J.2
-
33
-
-
0842278642
-
IL-21 induces the functional maturation of murine NK cells
-
Brady, J., Y. Hayakawa, M. J. Smyth, and S. L. Nutt. 2004. IL-21 induces the functional maturation of murine NK cells. J. Immunol. 172: 2048-2058.
-
(2004)
J. Immunol.
, vol.172
, pp. 2048-2058
-
-
Brady, J.1
Hayakawa, Y.2
Smyth, M.J.3
Nutt, S.L.4
-
34
-
-
0022616253
-
Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy
-
Karre, K., H. G. Ljunggren, G. Piontek, and R. Kiessling. 1986. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 319: 675-678.
-
(1986)
Nature
, vol.319
, pp. 675-678
-
-
Karre, K.1
Ljunggren, H.G.2
Piontek, G.3
Kiessling, R.4
-
35
-
-
0037111464
-
Cutting edge: Tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin
-
Hayakawa, Y., J. M. Kelly, J. A. Westwood, P. K. Darcy, A. Diefenbach, D. Raulet, and M. J. Smyth. 2002. Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin. J. Immunol. 169: 5377-5381.
-
(2002)
J. Immunol.
, vol.169
, pp. 5377-5381
-
-
Hayakawa, Y.1
Kelly, J.M.2
Westwood, J.A.3
Darcy, P.K.4
Diefenbach, A.5
Raulet, D.6
Smyth, M.J.7
-
36
-
-
0032729476
-
Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells
-
Carnaud, C., D. Lee, O. Donnars, S. H. Park, A. Beavis, Y. Koezuka, and A. Bendelac. 1999. Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J. Immunol. 163: 4647-4650.
-
(1999)
J. Immunol.
, vol.163
, pp. 4647-4650
-
-
Carnaud, C.1
Lee, D.2
Donnars, O.3
Park, S.H.4
Beavis, A.5
Koezuka, Y.6
Bendelac, A.7
-
37
-
-
33847369755
-
Tumor cells loaded with α-galactosylceramide induce innate NKT and NK cell-dependent resistance to tumor implantation in mice
-
Shimizu, K., A. Goto, M. Fukui, M. Taniguchi, and S. Fujii. 2007. Tumor cells loaded with α-galactosylceramide induce innate NKT and NK cell-dependent resistance to tumor implantation in mice. J. Immunol. 178: 2853-2861.
-
(2007)
J. Immunol.
, vol.178
, pp. 2853-2861
-
-
Shimizu, K.1
Goto, A.2
Fukui, M.3
Taniguchi, M.4
Fujii, S.5
-
38
-
-
0033854136
-
The interface between innate and acquired immunity: Glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes
-
Nishimura, T., H. Kitamura, K. Iwakabe, T. Yahata, A. Ohta, M. Sato, K. Takeda, K. Okumura, K. L. Van, T. Kawano, et al. 2000. The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes. Int. Immunol. 12: 987-994.
-
(2000)
Int. Immunol.
, vol.12
, pp. 987-994
-
-
Nishimura, T.1
Kitamura, H.2
Iwakabe, K.3
Yahata, T.4
Ohta, A.5
Sato, M.6
Takeda, K.7
Okumura, K.8
Van, K.L.9
Kawano, T.10
-
39
-
-
10744230210
-
+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells
-
+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells. J. Immunol. 171: 5140-5147.
-
(2003)
J. Immunol.
, vol.171
, pp. 5140-5147
-
-
Hermans, I.F.1
Silk, J.D.2
Gileadi, U.3
Salio, M.4
Mathew, B.5
Ritter, G.6
Schmidt, R.7
Harris, A.L.8
Old, L.9
Cerundolo, V.10
-
41
-
-
46749156754
-
Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis
-
Coquet, J. M., S. Chakravarti, M. J. Smyth, and D. I. Godfrey. 2008. Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. J. Immunol. 180: 7097-7101.
-
(2008)
J. Immunol.
, vol.180
, pp. 7097-7101
-
-
Coquet, J.M.1
Chakravarti, S.2
Smyth, M.J.3
Godfrey, D.I.4
-
42
-
-
34547204946
-
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
-
Nurieva, R., X. O. Yang, G. Martinez, Y. Zhang, A. D. Panopoulos, L. Ma, K. Schluns, Q. Tian, S. S. Watowich, A. M. Jetten, and C. Dong. 2007. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448: 480-483.
-
(2007)
Nature
, vol.448
, pp. 480-483
-
-
Nurieva, R.1
Yang, X.O.2
Martinez, G.3
Zhang, Y.4
Panopoulos, A.D.5
Ma, L.6
Schluns, K.7
Tian, Q.8
Watowich, S.S.9
Jetten, A.M.10
Dong, C.11
-
43
-
-
0035165729
-
Perforin and interferon-γ activities independently control tumor initiation, growth, and metastasis
-
Street, S. E., E. Cretney, and M. J. Smyth. 2001. Perforin and interferon-γ activities independently control tumor initiation, growth, and metastasis. Blood 97: 192-197.
-
(2001)
Blood
, vol.97
, pp. 192-197
-
-
Street, S.E.1
Cretney, E.2
Smyth, M.J.3
-
44
-
-
0035071525
-
NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma
-
Smyth, M. J., N. Y. Crowe, and D. I. Godfrey. 2001. NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma. Int. Immunol. 13: 459-463.
-
(2001)
Int. Immunol.
, vol.13
, pp. 459-463
-
-
Smyth, M.J.1
Crowe, N.Y.2
Godfrey, D.I.3
-
45
-
-
0034970326
-
Critical contribution of IFN-γ and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of α-galactosylceramide
-
Hayakawa, Y., K. Takeda, H. Yagita, S. Kakuta, Y. Iwakura, K. L. Van, I. Saiki, and K. Okumura. 2001. Critical contribution of IFN-γ and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of α-galactosylceramide. Eur. J. Immunol. 31: 1720-1727.
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 1720-1727
-
-
Hayakawa, Y.1
Takeda, K.2
Yagita, H.3
Kakuta, S.4
Iwakura, Y.5
Van, K.L.6
Saiki, I.7
Okumura, K.8
-
46
-
-
34250173393
-
IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype
-
Casey, K. A., and M. F. Mescher. 2007. IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype. J. Immunol. 178: 7640-7648.
-
(2007)
J. Immunol.
, vol.178
, pp. 7640-7648
-
-
Casey, K.A.1
Mescher, M.F.2
-
47
-
-
39549101010
-
Interleukin-21 activates human natural killer cells and modulates their surface receptor expression
-
Skak, K., K. S. Frederiksen, and D. Lundsgaard. 2008. Interleukin-21 activates human natural killer cells and modulates their surface receptor expression. Immunology 123: 575-583.
-
(2008)
Immunology
, vol.123
, pp. 575-583
-
-
Skak, K.1
Frederiksen, K.S.2
Lundsgaard, D.3
-
48
-
-
34848927882
-
IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cells
-
Liu, S., G. Lizee, Y. Lou, C. Liu, W. W. Overwijk, G. Wang, and P. Hwu. 2007. IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cells. Int. Immunol. 19: 1213-1221.
-
(2007)
Int. Immunol.
, vol.19
, pp. 1213-1221
-
-
Liu, S.1
Lizee, G.2
Lou, Y.3
Liu, C.4
Overwijk, W.W.5
Wang, G.6
Hwu, P.7
-
49
-
-
0346993779
-
Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo
-
Brandt, K., S. Bulfone-Paus, A. Jenckel, D. C. Foster, R. Paus, and R. Ruckert. 2003. Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo. J. Invest. Dermatol. 121: 1379-1382.
-
(2003)
J. Invest. Dermatol.
, vol.121
, pp. 1379-1382
-
-
Brandt, K.1
Bulfone-Paus, S.2
Jenckel, A.3
Foster, D.C.4
Paus, R.5
Ruckert, R.6
-
50
-
-
0345257344
-
Interleukin-21 inhibits dendritic cell activation and maturation
-
Brandt, K., S. Bulfone-Paus, D. C. Foster, and R. Ruckert. 2003. Interleukin-21 inhibits dendritic cell activation and maturation. Blood 102: 4090-4098.
-
(2003)
Blood
, vol.102
, pp. 4090-4098
-
-
Brandt, K.1
Bulfone-Paus, S.2
Foster, D.C.3
Ruckert, R.4
-
51
-
-
67649203681
-
A vital role for interleukin-21 in the control of a chronic viral infection
-
Yi, J. S., M. Du, and A. J. Zajac. 2009. A vital role for interleukin-21 in the control of a chronic viral infection. Science 324: 1572-1576.
-
(2009)
Science
, vol.324
, pp. 1572-1576
-
-
Yi, J.S.1
Du, M.2
Zajac, A.J.3
-
52
-
-
67649217469
-
IL-21 is required to control chronic viral infection
-
Elsaesser, H., K. Sauer, and D. G. Brooks. 2009. IL-21 is required to control chronic viral infection. Science 324: 1569-1572.
-
(2009)
Science
, vol.324
, pp. 1569-1572
-
-
Elsaesser, H.1
Sauer, K.2
Brooks, D.G.3
-
53
-
-
67649234772
-
IL-21R on T cells is critical for sustained functionality and control of chronic viral infection
-
Frohlich, A., J. Kisielow, I. Schmitz, S. Freigang, A. T. Shamshiev, J. Weber, B. J. Marsland, A. Oxenius, and M. Kopf. 2009. IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science 324: 1576-1580.
-
(2009)
Science
, vol.324
, pp. 1576-1580
-
-
Frohlich, A.1
Kisielow, J.2
Schmitz, I.3
Freigang, S.4
Shamshiev, A.T.5
Weber, J.6
Marsland, B.J.7
Oxenius, A.8
Kopf, M.9
-
55
-
-
64849083153
-
IL-21 mediates suppressive effects via its induction of IL-10
-
Spolski, R., H. P. Kim, W. Zhu, D. E. Levy, and W. J. Leonard. 2009. IL-21 mediates suppressive effects via its induction of IL-10. J. Immunol. 182: 2859-2867.
-
(2009)
J. Immunol.
, vol.182
, pp. 2859-2867
-
-
Spolski, R.1
Kim, H.P.2
Zhu, W.3
Levy, D.E.4
Leonard, W.J.5
-
56
-
-
70350114258
-
Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism
-
Gelebart, P., Z. Zak, M. Anand, J. en-Bard, H. M. Amin, and R. Lai. 2009. Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism. Leukemia 23: 1836-1846.
-
(2009)
Leukemia
, vol.23
, pp. 1836-1846
-
-
Gelebart, P.1
Zak, Z.2
Anand, M.3
En-Bard, J.4
Amin, H.M.5
Lai, R.6
|