Mitochondrial proteomics in experimental autoimmune uveitis oxidative stress

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 12, 2009, Pages 5559-5566

  Saraswathy, Sindhu ^a   Rao, Narsing A ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACONITATE HYDRATASE; ALPHA CRYSTALLIN; BETA CRYSTALLIN; CALRETININ; HEAT SHOCK PROTEIN 70; MALATE DEHYDROGENASE; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; MITOCHONDRIAL PROTEIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; BETA CRYSTALLIN B2; BETA-CRYSTALLIN B2; FLUORESCENT DYE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNE UVEITIS; CONTROLLED STUDY; DOWN REGULATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MITOCHONDRIAL PROTEOMICS; MITOCHONDRION; MOUSE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; REAL TIME POLYMERASE CHAIN REACTION; TWO DIMENSIONAL GEL ELECTROPHORESIS; UVEITIS; WESTERN BLOTTING; ANIMAL; AUTOIMMUNE DISEASE; DISEASE MODEL; GENE EXPRESSION; ISOELECTRIC FOCUSING; MASS SPECTROMETRY; METABOLISM; RETINA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALPHA-CRYSTALLIN A CHAIN; ANIMALS; APOPTOSIS; AUTOIMMUNE DISEASES; BETA-CRYSTALLIN B CHAIN; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FLUORESCENT DYES; GENE EXPRESSION; HSP70 HEAT-SHOCK PROTEINS; IN SITU NICK-END LABELING; ISOELECTRIC FOCUSING; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; PROTEOMICS; RETINA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUPEROXIDE DISMUTASE; UVEITIS;

EID: 73349101064     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2842     Document Type: Article

References (38)

1. Wu GS, Lee TD, Moore RE, Rao NA. Photoreceptor mitochondrial tyrosine nitration in experimental uveitis. Invest Ophthalmol Vis Sci. 2005;46:2271-2281.
2. Ranjendram R, Saraswathy S, Rao NA. Photoreceptor mitochondrial oxidative stress in early experimental autoimmune uveoretinitis. Br J Ophthalmol. 2007;91:531-537.
3. Saraswathy S, Rao NA. Photoreceptor mitochondrial oxidative stress in experimental autoimmune uveitis. Ophthalmic Res. 2008; 40:160-164.
4. Khurana RN, Parikh JG, Saraswathy S, Wu GS, Rao NA. Mitochondrial oxidative DNA damage in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2008;49:3299-3304.
5. Bailey SM, Landar A, Darley-Usmar V. Mitochondrial proteomics in free radical research. Free Rad Biol Med. 2005;38:175-188.
6. Van den Bergh G, Arckens L. Fluorescent two-dimensional difference gel electrophoresis unveils the potential of gel-based proteomics. Curr Opin Biotechnol. 2004;15:38-43
7. Alban A, David SO, Bjorkesten L, et al. A novel experimental design for comparative two-dimensional gel analysis: two-dimensional difference gel electrophoresis incorporating a pooled internal standard. Proteomics. 2003;3:36-44.
8. Yaung J, Jin M, Barron E, et al. Alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Mol Vis. 2007;13:566-577.
9. Livak KJ, Schmitten TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(AAC(T) method. Methods. 2001;25:402-408.
10. Fridovich I. Superoxide radical and superoxide dismutases. Annu Rev Biochem. 1995;64:97-112.
11. Rao NA, Saraswathy S, Wu GS, Katselis GS, Wawrousek EF, Bhat S. Elevated retina-specific expression of the small heat shock protein, oA-crystallin, is associated with photoreceptor protection in experimental uveitis. Invest Ophthalmol Vis Sci. 2008;49:1161-1170.
12. Chambers C, Russell P. Sequence of the human lens beta B2-crystallin-encoding cDNA. Gene. 1993;133:295-299
13. Duncan MK, Banerjee-Basu S, McDermott JB, Piatorsky J. Sequence and expression of chicken beta A2- and beta B3-crystallins. Exp Eye Res. 1996;62:111-119
14. Norledge BV, Trinkl S, Jaenicke R, Slingsby C. The X-ray structure of a mutant eye lens beta B2-crystallin with truncated sequence extensions. Protein Sci. 1997;6:1612-1620.
15. Jobby MK, Sharma Y. Calcium binding to lens betaB2- and betaA3-crystallins suggests that all beta-crystallins are calcium-binding proteins. FEBSLettJ. 2007;274:4135-4147.
16. Whittaker R, Glassy MS, Gude N, Sussman MA, Gottlieb RA, Glem-botski CC. Kinetics of the translocation and phosphorylation of alpha B crystallin in mouse heart mitochondria during ex-vivo ischemia. Am J Physiol Heart Circ Physiol. 2009;296:H1633-H1642.
17. Jin JK, Whittaker R, Glassy MS, Barlow SB, Gottlieb RA, Glembotski CC. Localization of phosphorylated alpha B crystallin to heart mitochondria during ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2008;294:H337-H344.
18. De Los Rios P, Ben-Zvi A, Slutsky O, Azem A, Goloubinoff P. Hsp70 chaperones accelerate protein translocation and the unfolding of stable protein aggregates by entropic pulling. Proc Natl Acad Sci USA. 2006;103:6166-6171.
19. Liu Q, Krzewska J, Liberek K, Craig EA. Mitochondrial Hsp70 Ssc1: role in protein folding.JBiol Chem. 2001;276:6112-6118.
20. Schneider HC, Berthold J, Bauer MF, et al. Mitochondrial Hsp70/ MIM44 complex facilitates protein import. Nature. 1994;371:768-774.
21. Neupert W, Brunner M. The protein import motor of mitochondria. Nat Rev Mol Cell Biol. 2002;3:555-565.
22. 2+ channels. J Cell Biol. 2006;175:901-911
23. Lill R, Muhlenhoff U. Iron-sulphur protein biogenesis in eukaryotes: components and mechanisms. Annu Rev Cell Dev Biol. 2006;22:457-486.
24. Verweij BH, Muizelaar JP, Vinas FC, Peterson PL, Xiong Y, Lee CP. Impaired cerebral mitochondrial function after traumatic brain injury in humans. JNeurosurg. 2000;93:815-820.
25. Bornhovd C, Vogel F, Neupert W, Reichert AS. Mitochondrial membrane potential is dependent on the oligomeric state of F1FO-ATP synthase supracomplexes. J Biol Chem. 2006;281:13990-13998.
26. +/~ mice. Two-stage oxidative injury. Toxicol Appl Pharmacol. 2008;231:43-51
27. Ruepp SU, Tonge RP, Shaw J, Wallis N, Pognan F. Genomics and proteomics analysis of acetaminophen toxicity in mouse liver. Toxicol Sci. 2002;65:135-150.
28. Vasquez-Vivar J, Kalyanaraman B, Kennedy MC. Mitochondrial aconitase is a source of hydroxyl radical: an electron spin resonance investigation.JBiol Chem. 2000;275:14064-14069.
29. Ong MM, Latchoumycandane C, Boelsterli UA. Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities. Toxicol Sci. 2007;97:205-213
30. Gardner PR, Raineri I, Epstein LB, White CW. Superoxide radical and iron modulate aconitase activity in mammalian cells. J Biol Chem. 1995;270:13399-13405.
31. Ruiz-Romero C, Carreira V, Rego I, Remesceiro J, Lopez-Armada MJ, Blanco FJ. Proteomic analysis of human osteoarthritic chondrocytes reveals protein changes in stress and glycolysis. Proteomics. 2008;8:495-507.
32. Nicholls DG, Ward MW. Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts. Trends Neurosci. 2000;23:166-174.
33. Rego AC, Oliveira CR. Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases. Neurochem Res. 2003;28:1563-1574.
34. Lifshitz J, Sullivan PG, Hovda DA, Wieloch T, McIntosh TK. Mito-chondrial damage and dysfunction in traumatic brain injury. Mitochondrion. 2004;4:705-713.
35. Sullivan PG, Rabchevsky AG, Waldmeir PC, Springer JE. Mitochon-drial permeability transition in CNS trauma: cause or effect of neuronal cell death? J Neurosci Res. 2005;79:231-239.
36. Bradbury MW, Berk PD. Mitochondrial aspartate aminotransferase: direction of a single protein with two distinct functions to two subcellular sites does not require alternative splicing of the mRNA. Biochem J. 2000;345:423-427.
37. Van Houten B, Woshner V, Santos JH. Role of mitochondrial DNA in toxic responses to oxidative stress. DNA Repair. 2006;5:145-152.
38. Xie L, Zhu X, Hu Y, et al. Mitochondrial DNA oxidative damage triggers mitochondrial dysfunction and apoptosis in high glucose-induced human retinal vascular endothelial cells. Invest Ophthal-mol Vis Sci. 2008;49:4203-4209.