The X-ray structure of a mutant eye lens βB2-crystallin with truncated sequence extensions

Protein Science

Volumn 6, Issue 8, 1997, Pages 1612-1620

  Norledge, B V ^a   Trinkl, S ^b   Jaenicke, R ^b   Slingsby, C ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Domain interactions; Extension; Linker; B2 crystallin

Indexed keywords

BETA CRYSTALLIN;

ARTICLE; CRYSTAL STRUCTURE; LENS; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STABILITY; X RAY CRYSTALLOGRAPHY;

EID: 0030847791     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560060802     Document Type: Article

References (29)

1. Bax B, Lapatto R, Nalini V, Driessen H, Lindley PF, Mahadevan D, Blundell TL, Slingsby C. 1990. X-ray analysis of βB2-crystallin and evolution of oligomeric lens proteins. Nature 347:776-780.
2. Bax B, Slingsby C. 1989. Crystallisation of a new form of the eye lens protein βB2-crystallin. J Mol Biol 208:715-717.
3. Benedek GB. 1971. Theory of transparency of the eye. Appl Optics 10:459-473.
4. Bennett M J, Schlunegger MP, Eisenberg D. 1995. 3D Domain swapping - A mechanism for oligomer assembly. Protein Sci 4:2455-2468.
5. Blundell T, Lindley P, Miller L, Moss D, Slingsby C, Tickle I, Turnell B, Wistow G. 1981. The molecular structure and stability of the eye lens: X-ray analysis of γ-crystallin II. Nature 289:771-777.
6. Brunger AT, Kuryan J, Karplus M. 1987. Crystallographic R-factor refinement by molecular dynamics. Science 235:458-460.
7. Carver JA, Cooper PG, Truscott JW. 1993. 1-NMR spectroscopy of βB2-crystallin from bovine eye lens. Conformation of the N-and C-terminal extensions. Eur J Biochem 213:313-320.
8. Collaborative Computational Project, Number 4. 1994. The CCP4 Suite: Programs for protein crystallography. Acta Crystallogr D50:760-763.
9. David LL, Shearer TR, Shih M. 1993. Sequence analysis of lens β-crystallins suggests involvement of calpain in cataract formation. J Biol Chem 268:1937-1940.
10. De Jong WW, Lubsen NH, Kraft HJ. 1994. Molecular evolution of the eye lens. Prog Ret Eye Res 13:391-442.
11. Fletterick RJ, Bazan JF. 1995. When one and one are nor two. Nat Struct Biol 2:721-723.
12. Harding JJ, Crabbe MJC. 1984. The lens: Development, proteins, metabolism, and cataract. In: Davson H, ed. The eye, vol. 1B, 3rd ed. London: Academic Press. pp 207-492.
13. Jones TA, Kjeldgaard M. 1994. Proceedings of the CCP4 Study Weekend, SERC Daresbury Laboratory, Warrington WA4 4AD, UK.
14. Kearsley SK. 1989. On the orthogonal transformation used for structural comparisons. Acta Crystallogr A45:208-210.
15. Kabsch W. 1993. Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants. J Appl Crystallogr 26:795-800.
16. suc1, in a strand-exchanged dimer. Structure 4:299-309.
17. Kroone RC, Elliott GS, Ferszt A, Slingsby C, Lubsen NH, Schoenmakers JGG. 1994. The role of the sequence extensions in β-crystallin assembly. Protein Eng 7:1395-1399.
18. Lapatlo R, Nalini V, Bax B, Driessen H, Lindley PF, Blundell TL, Slingsby C. 1991. High resolution structure of an oligomeric eye lens β-crystallin - Loops, arches, linkers and interfaces in the βB2 dimer compared to a monomeric γ-crystallin. J Mol Biol 222:1067-1083.
19. Laskowski RA, MacArthur MW, Moss DS, Thornton JM. 1993. PROCHECK - A program to check the stereochemical quality of protein structures. J Appl Crystallogr 26:283-291.
20. Lee B, Richards FM. 1971. J Mol Biol 55:379-400.
21. Matthews BW. 1968. Solvent content of protein crystals. J Mol Biol 33:491-497.
22. Nalini V, Bax B, Driessen H, Moss DS, Lindley PF, Slingsby C. 1994. Close packing of an oligomeric eye lens β-crystallin induces loss of symmetry and ordering of sequence extensions. J Mol Biol 236:1250-1258.
23. Norledge BV, Mayr E-M, Glockshuber R, Bateman OA, Slingsby C, Jaenicke R, Driessen HPC. 1996. The X-ray structures of two mutant crystallin domains shed light on the evolution of multi domain proteins. Nat Struct Biol 3:267-274.
24. Otwinowski Z. 1993. Oscillation data reduction program. In: Sawyer L, Isaacs N, Bailey S, eds. Data collection and processing, proceedings of the CCP4 study weekend, 29-30 January 1993. UK: SERC, Daresbury Laboratory. pp 56-62.
25. Sharma Y, Rao CM, Narasu ML, Rao SC, Somasundaram T, Gopalakrishna A, Balasubramanian D. 1989. Calcium ion binding to δ-crystallin and to β-crystallin. The presence of the EF-hand motif in δ-crystallin that aids in calcium-ion binding. J Biol Chem 264:12794-12799.
26. Trinkl S, Glockshuber R, Jaenicke R. 1994. Dimerisation of βB2-crystallin: The role of the linker peptide and the N-and C-terminal extensions. Protein Sci 3:1392-1400.
27. Tumminia SJ, Jonak GJ, Focht RJ, Cheng Y-SE, Russell P. 1996. Cataractogenesis in transgenic mice containing the HIV-1 protease linked to the lens αA-crystallin promoter. J Biol Chem 271:425-431.
28. Wang DW, Driessen HPC, Tickle, IJ. 1991. MOLPACK: Molecular graphics for studying the packing of protein molecules in the crystallographic unit cell. J Mol Graph 9:28, 50-52.
29. Wistow GJ, Piatigorsky J. 1988. Lens crystallins: The evolution and expression of proteins for a highly specialized tissue. Annu Rev Biochem 57:479-504.