Technical pitfalls and improvements for high-speed screening and QSAR analysis to predict inhibitors of the human bile salt export pump (ABCB11/BSEP)

AAPS Journal

Volumn 11, Issue 3, 2009, Pages 581-589

  Saito, Hikaru ^a,b   Osumi, Masako ^c   Hirano, Hiroyuki ^a   Shin, Wangsoo ^a   Nakamura, Ryota ^a   Ishikawa, Toshihisa ^a,d  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c Integrated Imaging Research Support   (Japan)

^d RIKEN YOKOHAMA INSTITUTE   (Japan)

Author keywords

ABCB11; Bile salt; Inhibition; Intrahepatic cholestasis; QSAR analysis

Indexed keywords

ABC TRANSPORTER; ABCB11 TRANSPORTER; BETAMETHASONE; BILE SALT; BILE SALT EXPORT PUMP; BOSENTAN; CORTISONE; CYCLOSPORIN A; DEXAMETHASONE; FENDILINE; GLIBENCLAMIDE; HEMATOPOPHYRIN; LEUPEPTIN; NICARDIPINE; NOVOBIOCIN; PHEOPHORBIDE; PHEOPHORBIDE A; PORPHYRIN; PREDNISOLONE; PRENYLAMINE; TAUROCHOLIC ACID; TREHALOSE; TROGLITAZONE; UNCLASSIFIED DRUG;

ACCURACY; CHEMICAL MODIFICATION; COMPETITIVE INHIBITION; DRUG ACCUMULATION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TRANSPORT; GENE MUTATION; GENETIC ASSOCIATION; HUMAN; INHIBITION KINETICS; INTRAHEPATIC CHOLESTASIS; MEMBRANE VESICLE; MOLECULAR MECHANICS; NONHUMAN; PATHOGENESIS; PROTEIN STRUCTURE; QUALITY CONTROL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SCREENING TEST; SHORT SURVEY;

ATP-BINDING CASSETTE TRANSPORTERS; CHROMANS; DRUG EVALUATION, PRECLINICAL; HUMANS; QUALITY CONTROL; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES;

EID: 73349090554     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-009-9137-9     Document Type: Short Survey

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