Immunity, autoimmunity and autoimmune diseases in older people

Journal of Biological Regulators and Homeostatic Agents

Volumn 22, Issue 4, 2008, Pages 217-224

  Rosato, E ^a   Salsano, Felice ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Autoantibodies; Autoimmune diseases; Immunosenescence

Indexed keywords

ACETYLSALICYLIC ACID; ANTINUCLEAR ANTIBODY; AUTOANTIBODY; C REACTIVE PROTEIN; CORTICOSTEROID; DISEASE MODIFYING ANTIRHEUMATIC DRUG; IMMUNOSUPPRESSIVE AGENT; NEUTROPHIL CYTOPLASMIC ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHOLIPID ANTIBODY; PREDNISONE; RHEUMATOID FACTOR; STEROID; THYROGLOBULIN ANTIBODY; THYROID ANTIBODY; THYROID PEROXIDASE ANTIBODY;

AGE DISTRIBUTION; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ANTIBODY TITER; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CANCER RISK; EDITORIAL; ERYTHROCYTE SEDIMENTATION RATE; GERIATRIC PATIENT; HUMAN; IMMUNE RESPONSE; INCIDENCE; INFECTION RISK; LIFE EXPECTANCY; LONGEVITY; LOW DRUG DOSE; MORTALITY; MYOSITIS; ONSET AGE; RHEUMATIC POLYMYALGIA; RHEUMATOID ARTHRITIS; RISK FACTOR; SEX DIFFERENCE; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS; TEMPORAL ARTERITIS; THYROIDITIS; UNSPECIFIED SIDE EFFECT; VASCULITIS;

AGED; AGING; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; AUTOIMMUNE DISEASES; AUTOIMMUNITY; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MYOSITIS; POLYMYALGIA RHEUMATICA; SCLERODERMA, SYSTEMIC; SJOGREN'S SYNDROME; THYROIDITIS, AUTOIMMUNE; VASCULITIS;

EID: 58149335347     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (38)

1. Ginald L, De Martinis M, D'Ostilio A, Marini L, Loreto MF, Quagliano D. Immunological changes in the elderly. Aging 1999; 11:281-6.
2. Aw D, Silva AB, Palmer DB. Imunosenescence: emerging challenges for an ageing population. Immunology 2007; 120:435-46.
3. Mocchegiani E, Malavolta M. NK and NKT cell functions in immunosenescence. Aging Cell 2004; 3: 177-84.
4. Torroba M, Zapata AG. Aging of the vertebrate immune system. Microsc Res Tech 2003; 62:477-81.
5. Naylor K, Li G, Vallejo AN, Lee WW, Koetz K, Bryl E, Witkowski J, Fulbright J, Weyand CM, Goronzy JJ. The influence of age on T cell generation and TCR diversity. J Immunol 2005; 174:7446-52.
6. Allman D, Miller JP. B cell development and receptor diversity during aging. Curr Opin Immunol 2005; 17: 463-7.
7. Ginaldi L, De Martinis M, Monti D, Franceschi C. The immune system in the elderly: activation-induced and damage-induced appptosis. Immunol Res 2004; 30:81-94.
8. Gruver AL, Hudson LL, Sempowski GD. Immunosenescence of ageing. J Pathol 2007; 211: 144-56.
9. Ramos-Casals M, Garcia-Carrasco M, Brito MP, Lopez-Soto A, Font J. Autoimmunity and geriatrics: clinical significance of autoimmune manifestations in the elderly. Lupus 2003; 12:341-55.
10. Ramos-Casals M, Brito-Zerón P, Lopez-Soto A, Font J. Systemic autoimmune diseases in elderly patients: Atypical presentation and association with neoplasia. Autoimmun Rev 2004; 3:376-82.
11. Stojanovich L, Marisavljevich D. Stress as a trigger of autoimmune disease. Autoimmun Rev 2008; 7: 209-13.
12. Serafini U, Torrigiani G, Masala C. Incidence of autoantibodies in the normal population. Folia Allergol 1965; 12:79-93.
13. Pinchera A, Mariotti S, Barbesino G, et al. Thyroid autoimmunity and ageing. Horm Res 1995; 43:64-8.
14. Mariotti S, Sansoni P, Barbesino G, et al. Thyroid and organ specific autoantibodies in healthy centenarians. Lancet 1992; 339:1506-8.
15. Newkirk MM. Rheumatoid factors: host resistance or autoimmunity? Clin Immunol 2002; 104:1-13.
16. Iakoubov LZ, Torchilin VP. A novel class of antitumour antibodies: nucleosome-restricted antinuclear autoantibodies (ANA) from healthy aged non-autoimmune mice. Oncol Res 1997; 9:439-46.
17. Torchilin VP, Iakoubov LZ, Estrov Z. Antinuclear autoantibodies as potential antineoplastic agents. Trends Immunol 2001; 22:424-7.
18. Fields RA, Toubbeh H, Searles RP, Bankhurst AD. The prevalence of anticardiolipin antibodies in a healthy elderly population and its association with antinuclear antibodies. J Rheumatol 1989; 16:623-5.
19. Mosek A, Yust I, Treves TA, Vardinon N, Korczyn AD, Chapman J. Dementia and antiphospholipid antibodies. Dement Geriatr Cogn Disord 2000; 11: 36-38.
20. Chen M, Yu F, Zhang Y, Zhao MH. Antineutrophil cytoplasmic autoantibody-associated vasculitis in older patients. Medicine (Baltimore) 2008; 87:203-9
21. Knockaert DC, Vanneste LJ, Bobbaers HJ. Fever of unknown origin in elderly patients. J Am Geriatr Soc 1993; 41:1187-92.
22. Hunder GG, Bloch DA, Michel BA et al. The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis. Arthritis Rheum 1990; 33:1122-8.
23. Salvarani C, Cantini F, Boiardi L, Hunder GG. Polymyalgia rheumatica and giant-cell arteritis. N Engl J Med 2002; 347:261-71.
24. Gonzalez-Gay MA. Giant cell arteritis and polymyalgia rheumatica: two different but often overlapping conditions. Semin Arthritis Rheum 2004; 33:289-93.
25. Hill. CL, Zhang Y, Sigurgeirsson B, Pukkala E, Mellemkjaer L, Airio A, Evans SR, Felson DT. Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet 2001; 357:96-100.
26. Ship JA, Pillemer SR, Baum BJ. Xerostomia and the geriatric patient. J Am Geriatr Soc 2002; 50:535-43.
27. Drosos AA, Andonopoulos AP, Costopoulos JS, Papadimitrou CS, Moutsopoulos HM. Prevalence of primary Sjögren's syndrome in an elderly population. Br J Rheumatol 1988; 27:123-7.
28. García-Carrasco M, Cervera R, Rosas J, et al. Primary Sjögren's syndrome in the elderly: clinical and immunological characteristics. Lupus 1999; 8: 20-23.
29. Haga HJ, Jonsson R. The influence of age on disease manifestations and serological characteristics in primary Sjögren's syndrome. Scand J Rheumatol 1999; 28:227-32.
30. Turkcapar N, Demir O, Atli T, Kopuk M, Turgay M, Kinikli G, Duman M. Late onset rheumatoid arthritis: clinical and laboratory comparisons with younger onset patients. Arch Gerontol Geriatr 2006; 42:225-31.
31. Uppal SS, Raghupathy R, Hayat SJ, Chowdhury RI, Abraham M, Rawoot P. Patient demographics and disease variables correlate with distinct cytokine patterns in mitogen-stimulated peripheral blood mononuclear cells from rheumatoid arthritis patients. Rheumatol Int 2008; 28:533-9.
32. Deal CL, Meenan RF, Goldenberg DL, Anderson JJ, Sack B, Pastan RS, Cohen AS. The clinical features of elderly-onset rheumatoid arthritis. A comparison with younger-onset disease of similar duration. Arthritis Rheum 1985; 28:987-94.
33. van der Heijde DM, van Riel PL, van Leeuwen MA, van't Hof MA, van Rijswijk MH, van De Putte LB. Older versus younger onset rheumatoid arthritis: results at onset and after 2 years of a prospective follow-up study of early rheumatoid arthritis. J Rheumatol 1991; 18:1285-9.
34. Rovenský J, Tuchyňová A. Systemic lupus erythematosus in the elderly. Autoimmun Rev 2008; 7: 235-9.
35. Kyndt X, Launay D, Hebbarmet AL, et al. Influence of age on the clinical and biological characteristics of systemic scleroderma. Rev Med Interne 1999; 20: 1088-92.
36. Schachna L, Wigley FM, Chang B, White B, Wise RA, Gelber AC. Age and risk of pulmonary arterial hypertension in scleroderma. Chest 2003; 124:2098-104.
37. Scorza R, Caronni M, Bazzi S, et al. Post-menopause is the main risk factor for developing isolated pulmonary hypertension in systemic sclerosis. Ann NY Acad Sci 2002; 966:238-46.
38. Mariotti s, Chiovato L, Franceschi C, Pinchera S. Thyroid autoimmunity and aging. Exp Gerontol 1998; 33:535-41.