T cell responses to steroid cytochrome P450 21-hydroxylase in patients with autoimmune primary adrenal insufficiency

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 12, 2009, Pages 5117-5124

  Bratland, Eirik ^a,b   Skinningsrud, Beate ^c,d   Undlien, Dag E ^c,d   Mozes, Edna ^e   Husebye, Eystein S ^a,b  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

^c ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^d UNIVERSITY OF OSLO   (Norway)

^e WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD32 ANTIGEN; FC RECEPTOR; GAMMA INTERFERON; HLA ANTIGEN; HLA DR ANTIGEN; IMMUNOGLOBULIN G; STEROID 21 MONOOXYGENASE;

ADDISON DISEASE; ADULT; AGED; ALLELE; ANTIGEN PRESENTING CELL; ARTICLE; CELL MATURATION; CELL PROLIFERATION; CELL STIMULATION; CELLULAR IMMUNITY; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; T LYMPHOCYTE;

EID: 73249117223     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-1115     Document Type: Article

References (39)

1. Husebye ES, Løvås K 2009 Immunology of Addison's disease and premature ovarian failure. Endocrinol Metab Clin North Am 38:389-405, ix
2. Løvås K, Husebye ES 2008 Replacement therapy for Addison's disease: recent developments. Expert Opin Investig Drugs 17:497-509
3. Winqvist O, Karlsson FA, Kämpe O 1992 21-Hydroxylase, a major autoantigen in idiopathic Addison's disease. Lancet 339:1559-1562
4. Bøe AS, Bredholt G, Knappskog PM, Hjelmervik TO, Mellgren G, Winqvist O, Kämpe O, Husebye ES 2004 Autoantibodies against 21-hydroxylase and side-chain cleavage enzyme in autoimmune Addison's disease are mainly immunoglobulin G1. Eur J Endocrinol 150:49-56
5. Gombos Z, Hermann R, Kiviniemi M, Nejentsev S, Reimand K, Fadeyev V, Peterson P, Uibo R, Ilonen J 2007 Analysis of extended human leukocyte antigen haplotype association with Addison's disease in three populations. Eur J Endocrinol 157:757-761
6. Myhre AG, Undlien DE, Løvås K, Uhlving S, Nedrebø BG, Fougner KJ, Trovik T, Sørheim JI, Husebye ES 2002 Autoimmune adrenocortical failure in Norway autoantibodies and human leukocyte antigen class II associations related to clinical features. J Clin Endocrinol Metab 87:618-623
7. Yu L, Brewer KW, Gates S, Wu A, Wang T, Babu SR, Gottlieb PA, Freed BM, Noble J, Erlich HA, Rewers MJ, Eisenbarth GS 1999 DRB1*04 and DQ alleles: expression of 21-hydroxylase autoantibodies and risk of progression to Addison's disease. J Clin Endocrinol Metab 84:328-335
8. Gregersen PK, Silver J, Winchester RJ 1987 The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 30:1205-1213
9. Hammer J, Gallazzi F, Bono E, Karr RW, Guenot J, Valsasnini P, Nagy ZA, Sinigaglia F 1995 Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association. J Exp Med 181:1847-1855
10. Arlt W, Allolio B 2003 Adrenal insufficiency. Lancet 361:1881-1893
11. Erlich H, Valdes AM, Noble J, Carlson JA, Varney M, Concannon P, Mychaleckyj JC, Todd JA, Bonella P, Fear AL, Lavant E, Louey A, Moonsamy P 2008 HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 57:1084-1092
12. Bratland E, Bredholt G, Mellgren G, Knappskog PM, Mozes E, Husebye ES 2009 The purification and application of biologically active recombinant steroid cytochrome P450 21-hydroxylase: the major autoantigen in autoimmune Addison's disease. J Autoimmun 33:58-67
13. Ravn P, Boesen H, Pedersen BK, Andersen P 1997 Human T cell responses induced by vaccination with Mycobacterium bovis bacillus Calmette-Guerin. J Immunol 158:1949-1955
14. Husebye ES, Bratland E, Bredholt G, Fridkin M, Dayan M, Mozes E 2006 The substrate-binding domain of 21-hydroxylase, the main autoantigen in autoimmune Addison's disease, is an immunodominant T cell epitope. Endocrinology 147:2411-2416
15. Nielsen M, Lundegaard C, Lund O 2007 Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method. BMC Bioinformatics 8:238
16. Roep BO, Kallan AA, Duinkerken G, Arden SD, Hutton JC, Bruining GJ, de Vries RR 1995 T-cell reactivity to β-cell membrane antigens associated with β-cell destruction in IDDM. Diabetes 44:278-283
17. Böyum A 1968 Separation of leukocytes from blood and bone marrow. Introduction. Scand J Clin Lab Invest Suppl 97:7
18. Listvanova S, Temmerman S, Stordeur P, Verscheure V, Place S, Zhou L, Locht C, Mascart F 2003 Optimal kinetics for quantification of antigen-induced cytokines in human peripheral blood mononuclear cells by real-time PCR and by ELISA. J Immunol Methods 281:27-35
19. Halminen M, Klemetti P, Vaarala O, Hurme M, Ilonen J 1997 Interferon-γ production in antigen specific T cell response: quantitation of specific mRNA and secreted protein. Scand J Immunol 46:388-392
20. Sakagawa H, Miyazaki T, Fujihara M, Sato S, Yamaguchi M, Fukai K, Morioka M, Kato T, Azuma H, Ikeda H 2007 Generation of inflammatory cytokines and chemokines from peripheral blood mononuclear cells by HLA class II antibody-containing plasma unit that was associated with severe nonhemolytic transfusion reactions. Transfusion 47:154-161
21. Reijonen H, Daniels TL, Lernmark A, Nepom GT 2000 GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65. Diabetes 49:1621-1626
22. Schlienger K, Craighead N, Lee KP, Levine BL, June CH 2000 Efficient priming of protein antigen-specific human CD4(+) T cells by monocyte-derived dendritic cells. Blood 96:3490-3498
23. Sapolsky RM, Romero LM, Munck AU 2000 How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 21:55-89
24. Gattoni A, Parlato A, Vangieri B, Bresciani M, Derna R 2006 Interferon-γ: biologic functions and HCV therapy (type I/II) (2 of 2 parts). Clin Ter 157:457-468
25. Gattoni A, Parlato A, Vangieri B, Bresciani M, Derna R 2006 Interferon-γ: biologic functions and HCV therapy (type I/II) (1 of 2 parts). Clin Ter 157:377-386
26. Jackson R, McNicol AM, Farquharson M, Foulis AK 1988 Class II MHC expression in normal adrenal cortex and cortical cells in autoimmune Addison's disease. J Pathol 155:113-120
27. Skoskiewicz MJ, Colvin RB, Schneeberger EE, Russell PS 1985 Widespread and selective induction of major histocompatibility complex-determined antigens in vivo by γ interferon. J Exp Med 162:1645-1664
28. Kisand K, Link M, Wolff AS, Meager A, Tserel L, Org T, Murumägi A, Uibo R, Willcox N, Trebusak Podkrajsek K, Battelino T, Lobell A, Kämpe O, Lima K, Meloni A, Ergun-Longmire B, Maclaren NK, Perheentupa J, Krohn KJ, Scott HS, Husebye ES, Peterson P 2008 Interferon autoantibodies associated with AIRE-deficiency decrease the expression of IFN-stimulated genes. Blood 112:2657-2666
29. Rotondi M, Falorni A, De Bellis A, Laureti S, Ferruzzi P, Romagnani P, Buonamano A, Lazzeri E, Crescioli C, Mannelli M, Santeusanio F, Bellastella A, Serio M 2005 Elevated serum interferon-γ-inducible chemokine-10/CXC chemokine ligand-10 in autoimmune primary adrenal insufficiency and in vitro expression in human adrenal cells primary cultures after stimulation with proinflammatory cytokines. J Clin Endocrinol Metab 90:2357-2363
30. Rabinovitch N, Gelfand EW 2004 Expression of functional activating and inhibitory Fcγ receptors on human B cells. Int Arch Allergy Immunol 133:285-294
31. Olweus J, BitMansour A, Warnke R, Thompson PA, Carballido J, Picker LJ, Lund-Johansen F 1997 Dendritic cell ontogeny: a human dendritic cell lineage of myeloid origin. Proc Natl Acad Sci USA 94:12551-12556
32. Allen JS, Pang K, Skowera A, Ellis R, Rackham C, Lozanoska-Ochser B, Tree T, Leslie RD, Tremble JM, Dayan CM, Peakman M 2009 Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture. Diabetes 58:138-145
33. Capel PJ, van de Winkel JG, van den Herik-Oudijk IE, Verbeek JS 1994 Heterogeneity of human IgG Fc receptors. Immunomethods 4:25-34
34. Barker JM, Ide A, Hostetler C, Yu L, Miao D, Fain PR, Eisenbarth GS, Gottlieb PA 2005 Endocrine and immunogenetic testing in individuals with type 1 diabetes and 21-hydroxylase autoantibodies: Addison's disease in a high-risk population. J Clin Endocrinol Metab 90:128-134
35. Undlien DE, Friede T, Rammensee HG, Joner G, Dahl-Jørgensen K, Søvik O, Akselsen HE, Knutsen I, Rønningen KS, Thorsby E 1997 HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection. Diabetes 46:143-149
36. Levisetti MG, Lewis DM, Suri A, Unanue ER 2008 Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice. Diabetes 57:1852-1860
37. Begovich AB, McClure GR, Suraj VC, Helmuth RC, Fildes N, Bugawan TL, Erlich HA, Klitz W 1992 Polymorphism, recombination, and linkage disequilibrium within the HLA class II region. J Immunol 148:249-258
38. Akbar SM, Yamamoto K, Miyakawa H, Ninomiya T, Abe M, Hiasa Y, Masumoto T, Horiike N, Onji M 2001 Peripheral blood T-cell responses to pyruvate dehydrogenase complex in primary biliary cirrhosis: role of antigen-presenting dendritic cells. Eur J Clin Invest 31:639-646
39. Narendran P, Elsegood K, Leech NJ, Macindoe WM, Boons GJ, Dayan CM 2004 Dendritic cell-based assays, but not mannosylation of antigen, improves detection of T-cell responses to proinsulin in type 1 diabetes. Immunology 111:422-429