Autoantibodies against 21-hydroxylase and side-chain cleavage enzyme in autoimmune Addison's disease are mainly immunoglobulin G1

European Journal of Endocrinology

Volumn 150, Issue 1, 2004, Pages 49-56

  Bøe, Anette S ^a   Bredholt, Gier ^a   Knappskog, Per M ^a   Hjelmervik, Trond Ove ^a   Mellgren, Gunnar ^a   Winqvist, Ola ^b   Kämpe, Olle ^b   Husebye, Eystein S ^a  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); HISTIDINE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN SUBCLASS; STEROID 21 MONOOXYGENASE;

ADDISON DISEASE; ADRENAL CORTEX DISEASE; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNE DISEASE; BACTERIAL STRAIN; BACULOVIRUS EXPRESSION SYSTEM; BINDING AFFINITY; BLOOD DONOR; CELL INCLUSION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; ESCHERICHIA COLI; HUMAN; HUMAN CELL; INSECT CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; TH1 CELL; TISSUE INJURY; WESTERN BLOTTING;

ADDISON DISEASE; ANTIBODY SPECIFICITY; AUTOANTIBODIES; BIOLOGICAL MARKERS; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; IMMUNOGLOBULIN G; STEROID 21-HYDROXYLASE; T-LYMPHOCYTES;

EID: 0742289425     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1500049     Document Type: Article

References (45)

1. The Finnish-German APECED Consortium. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. The Finnish-German APECED Consortium. Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy. Nature Genetics 1997 17 399-403.
2. Nagamine K, Peterson P, Scott HS, Kudoh J, Minoshima S, Heino M et al. Positional cloning of the APECED gene. Nature Genetics 1997 17 393-398.
3. Betterle C, Greggio NA & Volpato M. Clinical review 93: Autoimmune polyglandular syndrome type 1. Journal of Clinical Endocrinology and Metabolism 1998 83 1049-1055.
4. Betterle C, Dal Pra C, Mantero F & Zanchetta R. Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocrine Reviews 2002 23 327-364.
5. Myhre AG, Undlien DE, Lovas K, Uhlving S, Nedrebo BG, Fougner KJ et al. Autoimmune adrenocortical failure in Norway autoantibodies and human leukocyte antigen class II associations related to clinical features. Journal of Clinical Endocrinology and Metabolism 2002 87 618-623.
6. Winqvist O, Karlsson FA & Kampe O. 21-Hydroxylase, a major autoantigen in idiopathic Addison's disease. Lancet 1992 339 1559-1562.
7. Bednarek J, Furmaniak J, Wedlock N, Kiso Y, Baumann-Antczak A, Fowler S et al. Steroid 21-hydroxylase is a major autoantigen involved in adult onset autoimmune Addison's disease. FEBS Letters 1992 309 51-55.
8. Uibo R, Aavik E, Peterson P, Perheentupa J, Aranko S, Pelkonen R et al. Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease. Journal of Clinical Endocrinology and Metabolism 1994 78 323-328.
9. Winqvist O, Gustafsson J, Rorsman F, Karlsson FA & Kampe O. Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease. Journal of Clinical Investigation 1993 92 2377-2385.
10. Krohn K, Uibo R, Aavik E, Peterson P & Savilahti K. Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17 alpha-hydroxylase. Lancet 1992 339 770-773.
11. Falorni A, Nikoshkov A, Laureti S, Grenback E, Hulting AL, Casucci G et al. High diagnostic accuracy for idiopathic Addison's disease with a sensitive radiobinding assay for autoantibodies against recombinant human 21-hydroxylase. Journal of Clinical Endocrinology and Metabolism 1995 80 2752-2755.
12. Betterle C, Volpato M, Rees Smith B, Furmaniak J, Chen S, Zanchetta R et al. II. Adrenal cortex and steroid 21-hydroxylase autoantibodies in children with organ-specific autoimmune diseases: markers of high progression to clinical Addison's disease. Journal of Clinical Endocrinology and Metabolism 1997 82 939-942.
13. Chen S, Sawicka J, Betterle C, Powell M, Prentice L, Volpato M et al. Autoantibodies to steroidogenic enzymes in autoimmune polyglandular syndrome, Addison's disease, and premature ovarian failure. Journal of Clinical Endocrinology and Metabolism 1996 81 1871-1876.
14. Betterle C, Volpato M, Pedini B, Chen S, Smith BR & Furmaniak J. Adrenal-cortex autoantibodies and steroid-producing cells autoantibodies in patients with Addison's disease: comparison of immunofluorescence and immunoprecipitation assays. Journal of Clinical Endocrinology and Metabolism 1999 84 618-622.
15. Ishizaka A, Joh K, Shibata R, Wagatsuma Y, Nakanishi M, Tomizawa K et al. Regulation of IgE and IgG4 synthesis in patients with hyper IgE syndrome. Immunology 1990 70 414-416.
16. Trembleau S, Penna G, Bosi E, Mortara A, Gately MK & Adorini L. Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. Journal of Experimental Medicine 1995 181 817-821.
17. Yan XM, Guo J, Pichurin P, Tanaka K, Jaume JC, Rapoport B et al. Cytokines, IgG subclasses and costimulation in a mouse model of thyroid autoimmunity induced by injection of fibroblasts coexpressing MHC class II and thyroid autoantigens. Clinical and Experimenatal Immunology 2000 122 170-179.
18. Myhre AG, Halonen M, Eskelin P, Ekwall O, Hedstrand H, Rorsman F et al. Autoimmune polyendocrine syndrome type 1 (APS I) in Norway. Clinical Endocrinology 2001 54 211-217.
19. Hu MC, Guo IC, Lin JH & Chung BC. Regulated expression of cytochrome P-450scc (cholesterol-side-chain cleavage enzyme) in cultured cell lines detected by antibody against bacterially expressed human protein. Biochemical Journal 1991 274 813-817.
20. Reimer CB, Phillips DJ, Aloisio CH, Moore DD, Galland GG, Wells TW et al. Evaluation of thirty-one mouse monoclonal antibodies to human IgG epitopes. Hybridoma 1984 3 263-275.
21. Jefferis R, Reimer CB, Skvaril F, de Lange GG, Goodall DM, Bentley TL et al. Evaluation of monoclonal antibodies having specificity for human IgG subclasses: results of the 2nd IUIS/WHO collaborative study. Immunology Letters 1992 31 143-168.
22. Hamilton RG. Human IgG subclass measurements in the clinical laboratory. Clinical Chemistry 1987 33 1707-1725.
23. Freeman M & Weetman AP. T and B cell reactivity to adrenal antigens in autoimmune Addison's disease. Clinical and Experimental Immunology 1992 88 275-279.
24. Rabinowe SL, Jackson RA, Dluhy RG & Williams GH. Ia-positive T lymphocytes in recently diagnosed idiopathic Addison's disease. American Journal of Medicine 1984 77 597-601.
25. Maclaren NK & Riley WJ. Inherited susceptibility to autoimmune Addison's disease is linked to human leukocyte antigens-DR3 and/or DR4, except when associated with type I autoimmune polyglandular syndrome. Journal of Clinical Endocrinology and Metabolism 1986 62 455-459.
26. Weetman AP, Zhang L, Tandon N & Edwards OM. HLA associations with autoimmune Addison's disease. Tissue Antigens 1991 38 31-33.
27. Dean BM, Bottazzo GF & Cudworth AG. IgG subclass distribution in organ specific autoantibodies. The relationship to complement fixing ability. Clinical and Experimental Immunology 1983 52 61-66.
28. Liiv I, Teesalu K, Peterson P, Clemente MG, Perheentupa J & Uibo R. Epitope mapping of cytochrome P450 cholesterol side-chain cleavage enzyme by sera from patients with autoimmune polyglandular syndrome type 1. European Journal of Endocrinology 2002 146 113-119.
29. Hawa MI, Fava D, Medici F, Deng YJ, Notkins AL, De Mattia G et al. Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: isotype restriction and polyclonality. Diabetes Care 2000 23 228-233.
30. Couper JJ, Harrison LC, Aldis JJ, Colman PG, Honeyman MC & Ferrante A. IgG subclass antibodies to glutamic acid decarboxylase and risk for progression to clinical insulin-dependent diabetes. Human Immunology 1998 59 493-499.
31. Nikoshkov A, Falorni A, Lajic S, Laureti S, Wedell A, Lernmark K et al. A conformation-dependent epitope in Addison's disease and other endocrinological autoimmune diseases maps to a carboxylterminal functional domain of human steroid 21-hydroxylase. Journal of Immunology 1999 162 2422-2426.
32. Sousa AO, Henry S, Maroja FM, Lee FK, Brum L, Singh M et al. IgG subclass distribution of antibody responses to protein and polysaccharide mycobacterial antigens in leprosy and tuberculosis patients. Clinical and Experimental Immunology 1998 111 48-55.
33. Widhe M, Ekerfelt C, Forsberg P, Bergstrom S & Ernerudh J. IgG subclasses in Lyme borreliosis: a study of specific IgG subclass distribution in an interferon-gamma-predominated disease. Scandanavian Journal of Immunology 1998 47 575-581.
34. Metzger R, Mempel T, Joppich I & Till H. Organ-specific distribution of major histocompatibility antigens in rats. Pediatric Surgery International 2000 16 285-292.
35. Alarcon-Segovia D. Antinuclear antibodies: to penetrate or not to penetrate, that was the question. Lupus 2001 10 315-318.
36. Furmaniak J, Kominami S, Asawa T, Wedlock N, Colls J & Smith BR. Autoimmune Addison's disease - evidence for a role of steroid 21-hydroxylase autoantibodies in adrenal insufficiency. Journal of Clinical Endocrinology and Metabolism 1994 79 1517-1521.
37. Husebye ES, Boe AS, Rorsman F, Kampe O, Aakvaag A, Rygh T et al. Inhibition of aromatic L-amino acid decarboxylase activity by human autoantibodies. Clinical and Experimental Immunology 2000 120 420-423.
38. Boscaro M, Betterle C, Volpato M, Fallo F, Furmaniak J, Rees Smith B et al. Hormonal responses during various phases of autoimmune adrenal failure: no evidence for 21-hydroxylase enzyme activity inhibition in vivo. Journal of Clinical Endocrinology and Metabolism 1996 81 2801-2804.
39. Levine S & Wenk EJ. The production and passive transfer of allergic adrenalitis. American Journal of Pathology 1968 52 41-54.
40. Fujii Y, Kato N, Kito J, Asai J & Yokochi T. Experimental autoimmune adrenalitis: a murine model for Addison's disease. Autoimmunity 1992 12 47-52.
41. Regnault A, Lankar D, Lacabanne V, Rodriguez A, Thery C, Rescigno M et al. Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. Journal of Experimental Medicine 1999 189 371-380.
42. Machy P, Serre K & Leserman L. Class I-restricted presentation of exogenous antigen acquired by Fcgamma receptor-mediated endocytosis is regulated in dendritic cells. European Journal of Immunology 2000 30 848-857.
43. Hamano Y, Arase H, Saisho H & Saito T. Immune complex and Fc receptor-mediated augmentation of antigen presentation for in vivo Th cell responses. Journal of Immunology 164 6113-6119.
44. Watts C, Antoniou A, Manoury B, Hewitt EW, McKay LM, Grayson L et al. Modulation by epitope-specific antibodies of class II MHC-restricted presentation of the tetanus toxin antigen. Immunological Reviews 1998 164 11-16.
45. Hrda P, Sterzl I & Matucha P. Comparison of cytokine levels in sera of patients with autoimmune endocrinopathies. Physiology Research 2003 52 265-267.