The substrate-binding domain of 21-hydroxylase, the main autoantigen in autoimmune Addison's disease, is an immunodominant T cell epitope

Endocrinology

Volumn 147, Issue 5, 2006, Pages 2411-2416

  Husebye, Eystein S ^a,b,c   Bratland, Eirik ^b,c   Bredholt, Geir ^b   Fridkin, Mati ^a   Dayan, Molly ^a   Mozes, Edna ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

21 HYDROXYLASE PROTEIN[191-202]; 21 HYDROXYLASE PROTEIN[342-361]; 21 HYDROXYLASE PROTEIN[346-361]; AUTOANTIBODY; AUTOANTIGEN; BIOLOGICAL MARKER; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RECOMBINANT ANTIGEN; STEROID 21 MONOOXYGENASE; T LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG;

ADDISON DISEASE; ADRENAL INSUFFICIENCY; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN DETECTION; ARTICLE; AUTOIMMUNE DISEASE; BINDING AFFINITY; BINDING SITE; CELL STIMULATION; CONTROLLED STUDY; CYTOLOGY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; FEMALE; IMMUNIZATION; IN VITRO STUDY; LYMPH NODE CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; STEROID BINDING; STEROIDOGENESIS; T LYMPHOCYTE; TISSUE INJURY;

ADDISON DISEASE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; ANTIGENS, CD8; AUTOIMMUNE DISEASES; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITOPES; EPITOPES, T-LYMPHOCYTE; FEMALE; HUMANS; IMMUNODOMINANT EPITOPES; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MICE; MICE, INBRED BALB C; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STEROID 21-HYDROXYLASE; SUBSTRATE SPECIFICITY; T-LYMPHOCYTES;

EID: 33645850141     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2006-0018     Document Type: Article

References (28)

1. Ten S, New M, Maclaren N 2001 Clinical review 130: Addison's disease 2001. J Clin Endocrinol Metab 86:2909-2922
2. Winqvist O, Karlsson FA, Kämpe O 1992 21-Hydroxylase, a major autoantigen in idiopathic Addison's disease. Lancet 339:1559-1562
3. Falorni A, Nikoshkov A, Laureti S, Grenback E, Hulting AL, Casucci G, Santeusanio F, Brunetti P, Luthman H, Lernmark A 1995 High diagnostic accuracy for idiopathic Addison's disease with a sensitive radiobinding assay for autoantibodies against recombinant human 21-hydroxylase. J Clin Endocrinol Metab 80:2752-2755
4. Freeman M, Weetman AP 1992 T and B cell reactivity to adrenal antigens in autoimmune Addison's disease. Clin Exp Immunol 88:275-279
5. Hayashi Y, Hiyoshi T, Takemura T, Kurashima C, Hirokawa K 1989 Focal lymphocytic infiltration in the adrenal cortex of the elderly: immunohistological analysis of infiltrating lymphocytes. Clin Exp Immunol 77:101-105
6. Boscaro M, Betterle C, Volpato M, Fallo F, Furmaniak J, Rees Smith B, Sonino N 1996 Hormonal responses during various phases of autoimmune adrenal failure: no evidence for 21-hydroxylase enzyme activity inhibition in vivo. J Clin Endocrinol Metab 81:2801-2804
7. Nerup J, Andersen V, Bendixen G 1969 Anti-adrenal, cellular hypersensitivity in Addison's disease. Clin Exp Immunol 4:355-363
8. Nerup J, Andersen V, Bendixen G 1970 Anti-adrenal cellular hypersensitivity in Addison's disease. IV. In vivo and in vitro investigations on the mitochondrial fraction. Clin Exp Immunol 6:733-739
9. Rabinowe SL, Jackson RA, Dluhy RG, Williams GH 1984 Ia-positive T lymphocytes in recently diagnosed idiopathic Addison's disease. Am J Med 77:597-601
10. + regulatory T cells in autoimmune polyglandular syndrome type II. J Exp Med 199:1285-1291
11. Brocke S, Brautbar C, Steinman L, Abramsky O, Rothbard J, Neumann D, Fuchs S, Mozes E 1988 In vitro proliferative responses and antibody titers specific to human acetylcholine receptor synthetic peptides in patients with myasthenia gravis and relation to HLA class II genes. J Clin Invest 82:1894-1900
12. Brocke S, Dayan M, Rothbard J, Fuchs S, Mozes E 1990 The autoimmune response of different mouse strains to T-cell epitopes of the human acetylcholine receptor α subunit. Immunology 69:495-500
13. McLachlan SM, Rapoport B 2000 Autoimmune response to the thyroid in humans: thyroid peroxidase - the common autoantigenic denominator. Int Rev Immunol 19:587-618
14. Bøe AS, Bredholt G, Knappskog PM, Hjelmervik TO, Mellgren G, Winqvist O, Kämpe O, Husebye ES 2004 Autoantibodies against 21-hydroxylase and side-chain cleavage enzyme in autoimmune Addison's disease are mainly immunoglobulin G1. Eur J Endocrinol 150:49-56
15. Rammensee H, Bachmann J, Emmerich NP, Bachor OA, Stevanovic S 1999 SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenetics 50:213-219
16. Rothbard JB, Taylor WR 1988 A sequence pattern common to T cell epitopes. EMBO J 7:93-100
17. Kasher R, Gayer B, Kulik T, Somjen D, Venkatesh N, Fridkin M, Katchalski-Katzir E, Kohen F 2004 Design, synthesis, and evaluation of peptides with estrogen-like activity. Biopolymers 76:404-420
18. Axelrod O, Mozes E 1986 Analysis of the biological functions and fine specificity of (T,G)-A-L specific T cell clones. Immunobiology 172:99-109
19. Myhre AG, Undlien DE, Løvas K, Uhlving S, Nedrebø BG, Fougner KJ, Trovik T, Sørheim JI, Husebye ES 2002 Autoimmune adrenocortical failure in Norway autoantibodies and human leukocyte antigen class II associations related to clinical features. J Clin Endocrinol Metab 87:618-623
20. Li P, Gregg JL, Wang N, Zhou D, O'Donnell P, Blum JS, Crotzer VL 2005 Compartmentalization of class II antigen presentation: contribution of cytoplasmic and endosomal processing. Immunol Rev 207:206-217
21. Zhou D, Blum JS 2004 Presentation of cytosolic antigens via MHC class II molecules. Immunol Res 30:279-290
22. Lich JD, Elliott JF, Blum JS 2000 Cytoplasmic processing is a prerequisite for presentation of an endogenous antigen by major histocompatibility complex class II proteins. J Exp Med 191:1513-1524
23. McNicol AM 1986 Class II MHC antigen expression in adrenal cortex. Lancet 2:1282
24. Khoury EL, Greenspan JS, Greenspan FS 1987 Adrenocortical cells of the zona reticularis normally express HLA-DR antigenic determinants. Am J Pathol 127:580-591
25. Ma C, Whiteley PE, Cameron PM, Freed DC, Pressey A, Chen SL, Garni-Wagner B, Fang C, Zaller DM, Wicker LS, Blum JS 1999 Role of APC in the selection of immunodominant T cell epitopes. J Immunol 163:6413-6423
26. Picado-Leonard J, Miller WL 1988 Homologous sequences in steroidogenic enzymes, steroid receptors and a steroid binding protein suggest a consensus steroid-binding sequence. Mol Endocrinol 2:1145-1150
27. Martineau I, Belanger A, Tchernof A, Tremblay Y 2003 Molecular cloning and expression of guinea pig cytochrome P450c21 cDNA (steroid 21-hydroxylase) isolated from the adrenals. J Steroid Biochem Mol Biol 86:123-132
28. Higashi Y, Yoshioka H, Yamane M, Gotoh O, Fujii-Kuriyama Y 1986 Complete nucleotide sequence of two steroid 21-hydroxylase genes tandemly arranged in human chromosome: a pseudogene and a genuine gene. Proc Natl Acad Sci USA 83:2841-2845