Insights into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate

Journal of Molecular Biology

Volumn 395, Issue 2, 2010, Pages 375-389

  Zunszain, Patricia A ^a   Knox, Stephen R ^a   Sweeney, Trevor R ^a   Yang, Jingjie ^a   Roqué Rosell, Núria ^a   Belsham, Graham J ^b   Leatherbarrow, Robin J ^a   Curry, Stephen ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

3C protease; foot and mouth disease virus; peptide recognition; picornavirus; X ray crystallography

Indexed keywords

3C PROTEASE; ALANINE; ASPARTIC ACID; CYSTEINE; GLUTAMIC ACID; GLUTAMINE; HISTIDINE; LEUCINE; POLYPROTEIN; PROTEINASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; FOOT AND MOUTH DISEASE VIRUS; HYDROGEN BOND; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE ANALYSIS; PICORNAVIRUS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

FOOT-AND-MOUTH DISEASE VIRUS; PICORNAVIRIDAE;

EID: 73149105706     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.10.048     Document Type: Article

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