Dual modes of modification of hepatitis A virus 3C protease by a serine-derived β-lactone: Selective crystallization and formation of a functional catalytic triad in the active site

Journal of Molecular Biology

Volumn 354, Issue 4, 2005, Pages 854-871

  Yin, Jiang ^a   Bergmann, Ernst M ^a,b   Cherney, Maia M ^a   Lall, Manjinder S ^b   Jain, Rajendra P ^b   Vederas, John C ^b   James, Michael N G ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

3C protease; Hepatitis A; Inhibitor and antiviral drug design; Picornavirus; lactone

Indexed keywords

ANTIVIRUS AGENT; ASPARTIC ACID; CYSTEINE; ENZYME INHIBITOR; HEPATITIS A VIRUS 3C PROTEASE; HISTIDINE; LACTONE DERIVATIVE; N BENZYLOXYCARBONYLSERINE BETA LACTONE; N IODOACETYLVALYLPHENYLALANINAMIDE; PHENYL GROUP; SULFUR; UNCLASSIFIED DRUG; VIRUS ENZYME;

ALKYLATION; ARTICLE; ATOM; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME MODIFICATION; ENZYME STRUCTURE; ENZYME SYNTHESIS; HEPATITIS A VIRUS; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR INTERACTION; MOLECULE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INTERACTION; STATISTICAL SIGNIFICANCE; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS; VIRUS INFECTIVITY; X RAY ANALYSIS;

HEPATITIS A VIRUS; PICORNAVIRIDAE;

EID: 28444485316     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.09.074     Document Type: Article

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