The MDM2-binding region in the transactivation domain of p53 also acts as a Bcl-XL-binding motif

Biochemistry

Volumn 48, Issue 51, 2009, Pages 12159-12168

  Xu, Huibin ^a   Ye, Hong ^a   Osman, Nur Eliza ^a   Sadler, Kristen ^a   Won, Eun Young ^b   Chi, Seung Wook ^b   Yoon, Ho Sup ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; APOPTOTIC ACTIVITY; BINDING INTERFACE; BINDING MOTIF; CONFORMATIONAL CHANGE; DNA-BINDING DOMAIN; HELICAL STRUCTURES; HYDROPHOBIC POCKETS; MODE OF BINDING; N-TERMINAL DOMAINS; STRUCTURAL MODELS; STRUCTURAL STUDIES; TRANSACTIVATION DOMAIN;

BINDING ENERGY; CELL DEATH; HYDROPHOBICITY; MODEL STRUCTURES; OPTICAL COMMUNICATION; TRANSCRIPTION;

PEPTIDES;

PROTEIN BCL XL; PROTEIN MDM2; PROTEIN P53;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; DNA BINDING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN STRUCTURE;

AMINO ACID MOTIFS; BCL-X PROTEIN; BINDING SITES; HUMANS; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 73149101019     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901188s     Document Type: Article

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