In vitro receptor binding properties of a "painless" NGF mutein, linked to hereditary sensory autonomic neuropathy type V

Biochemical and Biophysical Research Communications

Volumn 391, Issue 1, 2010, Pages 824-829

  Covaceuszach, Sonia ^a   Capsoni, Simona ^b   Marinelli, Sara ^c   Pavone, Flaminia ^c   Ceci, Marcello ^b   Ugolini, Gabriele ^a   Vignone, Domenico ^b   Amato, Gianluca ^b   Paoletti, Francesca ^b   Lamba, Doriano ^d   Cattaneo, Antonino ^b,e  

^a Lay Line Genomics SpA   (Italy)

^b EUROPEAN BRAIN RESEARCH INSTITUTE   (Italy)

^c CNR   (Italy)

^d CNR   (Italy)

^e SCUOLA NORMALE SUPERIORE   (Italy)

Author keywords

Binding affinity; Human genetic disease; Nerve Growth Factor; p75NTR; Pain; TrkA

Indexed keywords

NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR P75; PROTEIN TYROSINE KINASE A;

ARTICLE; BINDING AFFINITY; ESCHERICHIA COLI; GENE MUTATION; HUMAN; IN VITRO STUDY; NEUROPATHY; NEUROPATHY TYPE V; PAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; SURFACE PLASMON RESONANCE;

ESCHERICHIA COLI; HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES; HUMANS; MUTATION; NERVE GROWTH FACTOR; NERVE TISSUE PROTEINS; PAIN INSENSITIVITY, CONGENITAL; PROTEIN CONFORMATION; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR; SURFACE PLASMON RESONANCE;

ESCHERICHIA COLI;

EID: 72949101768     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.11.146     Document Type: Article

References (34)

1. Levi-Montalcini R. Effects of mouse tumor transplantation on the nervous system. Ann. NY Acad. Sci. 55 (1952) 330-344
2. Barde Y.A., Edgar D., and Thoenen H. Purification of a new neurotrophic factor from mammalian brain. EMBO J. 1 (1982) 549-553
3. Hohn A., Leibrock J., Bailey K., and Barde Y.A. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 344 (1990) 339-341
4. Hallbook F., Ibanez C.F., and Persson H. Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron 6 (1991) 845-858
5. Johnson D., Lanahan A., Buck C.R., Sehgal A., Morgan C., Mercer E., Bothwell M., and Chao M. Expression and structure of the human NGF receptor. Cell 47 (1986) 545-554
6. Klein R., Jing S.Q., Nanduri V., O'Rourke E., and Barbacid M. The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65 (1991) 189-197
7. Kaplan D.R., Martin-Zanca D., and Parada L.F. Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature 350 (1991) 158-160
8. Pezet S., and McMahon S.B. Neurotrophins: mediators and modulators of pain. Annu. Rev. Neurosci. 29 (2006) 507-538
9. Nicol G.D., and Vasko M.R. Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: ON or OFF the Trks?. Mol. Interv. 7 (2007) 26-41
10. Apfel S.C. Nerve growth factor for the treatment of diabetic neuropathy: what went wrong, what went right, and what does the future hold?. Int. Rev. Neurobiol. 50 (2002) 393-413
11. Indo Y. Genetics of congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV. Clinical, biological and molecular aspects of mutations in TRKA(NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. Clin. Auton. Res. 12 Suppl. 1 (2002) I20-32
12. Einarsdottir E., Carlsson A., Minde J., Toolanen G., Svensson O., Solders G., Holmgren G., Holmberg D., and Holmberg M. A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception. Hum. Mol. Genet. 13 (2004) 799-805
13. Larsson E., Kuma R., Norberg A., Minde J., and Holmberg M. Nerve growth factor R221W responsible for insensitivity to pain is defectively processed and accumulates as proNGF. Neurobiol. Dis. 33 (2009) 221-228
14. de Andrade D.C., Baudic S., Attal N., Rodrigues C.L., Caramelli P., Lino A.M., Marchiori P.E., Okada M., Scaff M., Bouhassira D., and Teixeira M.J. Beyond neuropathy in hereditary sensory and autonomic neuropathy type V: cognitive evaluation. Eur. J. Neurol. 15 (2008) 712-719
15. Cattaneo A., Capsoni S., and Paoletti F. Towards non invasive Nerve Growth Factor therapies for Alzheimer's disease. J. Alzheimer's Dis. 15 (2008) 255-283
16. Covaceuszach S., Capsoni S., Ugolini G., Spirito F., Vignone D., and Cattaneo A. Development of a non invasive NGF-based therapy for Alzheimer's disease. Curr. Alzheimer Res. 6 (2009) 158-170
17. Rattenholl A., Lilie H., Grossmann A., Stern A., Schwarz E., and Rudolph R. The pro-sequence facilitates folding of human nerve growth factor from Escherichia coli inclusion bodies. Eur. J. Biochem. 268 (2001) 3296-3303
18. Paoletti F., Covaceuszach S., Konarev P.V., Gonfloni S., Malerba F., Schwarz E., Svergun D.I., Cattaneo A., and Lamba D. Intrinsic structural disorder of mouse proNGF. Proteins 75 (2009) 990-1009
19. Kliemannel M., Rattenholl A., Golbik R., Balbach J., Lilie H., Rudolph R., and Schwarz E. The mature part of proNGF induces the structure of its pro-peptide. FEBS Lett. 566 (2004) 207-212
20. Cattaneo A., Capsoni S., Margotti E., Righi M., Kontsekova E., Pavlik P., Filipcik P., and Novak M. Functional blockade of tyrosine kinase A in the rat basal forebrain by a novel antagonistic anti-receptor monoclonal antibody. J. Neurosci. 19 (1999) 9687-9697
21. He X.L., and Garcia K.C. Structure of nerve growth factor complexed with the shared neurotrophin receptor p75. Science 304 (2004) 870-875
22. Wehrman T., He X., Raab B., Dukipatti A., Blau H., and Garcia K.C. Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Neuron 53 (2007) 25-38
23. Wiesmann C., Ultsch M.H., Bass S.H., and de Vos A.M. Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature 401 (1999) 184-188
24. Krissinel E., and Henrick K. Inference of macromolecular assemblies from crystalline state. J. Mol. Biol. 372 (2007) 774-797
25. Cattaneo A., Capsoni S., and Paoletti F. A new generation of non invasive NGF-based therapies for Alzheimer's disease. In: Martinez A. (Ed). Emerging drugs & Targets for Alzheimer's disease (2009), RCS Publishing
26. Lee R., Kermani P., Teng K.K., and Hempstead B.L. Regulation of cell survival by secreted proneurotrophins. Science 294 (2001) 1945-1948
27. Verpoorten N., De Jonghe P., and Timmerman V. Disease mechanisms in hereditary sensory and autonomic neuropathies. Neurobiol. Dis. 21 (2006) 247-255
28. Dyck P.J., Mellinger J.F., Reagan T.J., Horowitz S.J., McDonald J.W., Litchy W.J., Daube J.R., Fealey R.D., Go V.L., Kao P.C., Brimijoin W.S., and Lambert E.H. Not 'indifference to pain' but varieties of hereditary sensory and autonomic neuropathy. Brain 106 Pt. 2 (1983) 373-390
29. Reichardt L.F. Neurotrophin-regulated signalling pathways. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 361 (2006) 1545-1564
30. Horigome K., Pryor J.C., Bullock E.D., and Johnson Jr. E.M. Mediator release from mast cells by nerve growth factor. Neurotrophin specificity and receptor mediation. J. Biol. Chem. 268 (1993) 14881-14887
31. Zhang Y.H., and Nicol G.D. NGF-mediated sensitization of the excitability of rat sensory neurons is prevented by a blocking antibody to the p75 neurotrophin receptor. Neurosci. Lett. 366 (2004) 187-192
32. Jansen P., Giehl K., Nyengaard J.R., Teng K., Lioubinski O., Sjoegaard S.S., Breiderhoff T., Gotthardt M., Lin F., Eilers A., Petersen C.M., Lewin G.R., Hempstead B.L., Willnow T.E., and Nykjaer A. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat. Neurosci. 10 (2007) 1449-1457
33. Obata K., Katsura H., Sakurai J., Kobayashi K., Yamanaka H., Dai Y., Fukuoka T., and Noguchi K. Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury. J. Neurosci. 26 (2006) 11974-11986
34. Watanabe T., Ito T., Inoue G., Ohtori S., Kitajo K., Doya H., Takahashi K., and Yamashita T. The p75 receptor is associated with inflammatory thermal hypersensitivity. J. Neurosci. Res. 86 (2008) 3566-3574