Functional blockade of tyrosine kinase A in the rat basal forebrain by a novel antagonistic anti-receptor monoclonal antibody

Journal of Neuroscience

Volumn 19, Issue 22, 1999, Pages 9687-9697

  Cattaneo, Antonino ^a   Capsoni, Simona ^a   Margotti, Elisa ^a   Righi, Massimo ^a   Kontsekova, Eva ^b   Pavlik, Peter ^b   Filipcik, Peter ^b   Novak, Michal ^a,b  

^a SISSA   (Italy)

^b INSTITUTE OF NEUROIMMUNOLOGY   (Slovakia)

Author keywords

Antagonist monoclonal antibody; Basal forebrain cholinergic neurons; NGF receptors; Rat; Recombinant antibody fragment; TrkA

Indexed keywords

NERVE GROWTH FACTOR ANTIBODY; NERVE GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; RECOMBINANT ANTIBODY;

ANIMAL CELL; ANTIBODY PRODUCING CELL; ARTICLE; CELL COUNT; CELL SIZE; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; ENZYME ANALYSIS; FOREBRAIN; GENE TRANSFER; IN VIVO STUDY; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT;

EID: 0033571969     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-22-09687.1999     Document Type: Article

References (53)

1. Avignone E, Molnar M, Berretta N, Casamenti F, Prosperi C, Ruberti F, Cattaneo A, Cherubini E (1998) Cholinergic function in the hippocampus of juvenile rats chronically deprived of NGF. Brain Res Dev Brain Res 109:137-147.
2. Batchelor PE, Armstrong DM, Blaker SN, Gage FH (1989) Nerve growth factor receptor and choline acetyltransferase colocalization in neurons within the rat forebrain: response to fimbria-fornix transection. J Comp Neurol 284:187-204.
3. Berardi N, Cellerino A, Domenici L, Fagiolini M, Pizzorusso T, Cattaneo A, Maffei L (1994) Monoclonal antibodies to nerve growth factor affect the postnatal development of the visual system. Proc Natl Acad Sci USA 91:684-688.
4. Bird RE, Hardman KD, Jacobson JW, Johnson S, Kaufman BM, Lee SM, Lee T, Pope SH, Riordan GS, Whitlow M (1988) Single-chain antigen-binding proteins. Science 242:423-425.
5. Bradbury A, Cattaneo A, Hoogenboom H (1996) Selecting from phage display libraries. In: Manual of the EMBO theoretical and practical course, pp 1-122. Trieste, Italy, November.
6. Cattaneo A, Biocca S, Nasi S, Calissano P (1983) Hidden receptors for nerve growth factors in PC12 cells. Eur J Biochem 135:285-290.
7. Cattaneo A, Rapposelli B, Calissano P (1988) Three distinct types of monoclonal antibodies after long term immunization of rats with mouse nerve growth factor. J Neurochem 50:1003-1010.
8. Chamow SM, Ashkenazi A (1996) Immunoadhesins: principles and applications. Trends Biotechnol 14:52-60.
9. Chao MV, Hempstead BL (1995) p75 and Trk: a two-receptor system. Trends Neurosci 18:321-326.
10. Chen KS, Nishimura MC, Armanini MP, Crowley C, Spencer SD, Phillips HS (1997) Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits. J Neurosci 17:7288-7296.
11. Clary DO, Weskamp G, Austin LR Reichardt LF (1994) TrkA cross-linking mimics neuronal responses to nerve growth factor. Mol Biol Cell 5:549-563.
12. Crowley C, Spencer SD, Nishimura MC, Chen KS, Pitts-Meek S, Armanini MP, Ling LH, MacMahon SB, Shelton DL, Levinson AD, Phillips HS (1994) Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 76:1001-1011.
13. Davies AM, Minichiello L, Klein R (1995) Developmental changes in NT3 signalling via TrkA and TrkB in embryonic neurons. EMBO J 14:4482-4489.
14. Di Stefano PS, Friedman B, Radieijewski C, Alexander C, Boland P, Schik CM, Lindsay RM, Wiegand SJ (1992) The neurotrophins BDNF, NT3, and NGF display distinct patterns of retrograde transport in peripheral and central neurons. Neuron 8:983-993.
15. Domenici L, Fontanesi G, Cattaneo A, Bagnoli P, Maffei L (1994a) Nerve growth factor (NGF) uptake and transport following injection in the developing rat visual cortex. Vis Neurosci 11:1093-1102.
16. Domenici L, Cellerino A, Berardi N, Cattaneo A, Maffei L (1994b) Antibodies to nerve growth factor (NGF) prolong the sensitive period for monocular deprivation in the rat. NeuroReport 5:2041-2044.
17. Dutar P, Bassant ME, Sen M, Lamour Y (1995) The septohippocampal pathway: structure and function of a central cholinergic system. Physiol Rev 75:393-427.
18. Fagan AM, Garber M, Barbacid M, Silos-Santiago I, Holtzman DM (1997) A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo. J Neurosci 17:7644-7654.
19. Frade JM, Barde YA (1998) Nerve growth factor: two receptors, multiple functions. BioEssays 20:137-145.
20. Galfre' G, Milstein C (1981) Preparation of monoclonal antibodies: strategies and procedures. Methods Enzymol 73:3-45.
21. Greene LA, Tischler AS (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73:2424-2428.
22. Hanke T, Szawlowski P, Randall RE (1992) Construction of solid matrix-antibody-antigen complexes containing simian immunodeficiency virus p27 using tag-specific monoclonal antibody and tag-linked antigen. J Gen Virol 73:653-660.
23. Hefti F (1986) Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. J Neurosci 6:2155-2162.
24. Holtzman DM, Li Y, Parada LF, Kinsman S, Chen C-K, Valletta JS, Zhou J, Long JB, Mobley WC (1992) p140 trk RNA marks NGF-responsive forebrain neurons: evidence that Trk gene expression is induced by NGF. Neuron 9:465-478.
25. Holtzman DM, Kilbridge J, Li Y, Cunningham Jr E, Lenn NJ, Clary D, Reichardt LF, Mobley WC (1995) TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons. J Neurosci 15:1567-1576.
26. Kaplan, DR, Hempstead BL, Martin-Zanca D, Chao MV, Parada LF (1991) The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science 252:554-558.
27. Katoh-Semba R, Kaisho Y, Shintani A, Nagahama M, Kato K (1996) Tissue distribution and immunocytochemical localization of neurotrophin-3 in the brain and peripheral tissues of rats. J Neurochem 66:330-337.
28. Kawaja MD, Rosenberg MB, Yoshida K, Gage FH (1992) Somatic gene transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of their axons in adult rats. J Neurosci 12:2849-2864.
29. Klein R, Jing S, Nanduri V, O'Rourke E, Barbacid M (1991) The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65:189-197.
30. Koh S, Higgins GA (1991) Differential regulation of the low affinity nerve growth factor receptor during postnatal development in the rat brain. J Comp Neurol 313:494-508.
31. Korsching S (1986) The role of nerve growth factor in the CNS. Trends Neurosci 9:570-573.
32. Krebber A, Bornhauser S, Burmester J, Honegger A, Willuda J, Bosshard HR, Pluckthun A (1997) Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system. J Immunol Methods 201:35-55.
33. LeSauteur L, Maliartchouk S, Le Jeune H, Quirion R, Saragovi HU (1996) Potent human p140-TrkA agonists derived from an anti-receptor monoclonal antibody. J Neurosci 16:1308-1316.
34. Lucidi-Phillipi CA, Clary DO, Reichardt LF, Gage FH (1996) TrkA activation is sufficient to rescue axotomized cholinergic neurons. Neuron 16:653-663.
35. Maliartchouk S, Saragovi HU (1997) Optimal nerve growth factor trophic signals mediated by synergy of TrkA and p75 receptor-specific ligands. J Neurosci 17:6031-6037.
36. Molnar M, Ruberti F, Cozzari C, Domenici L, Cattaneo A (1997) A critical period in the sensitivity of BF cholinergic neurons to NGF deprivation. NeuroReport 8:575-579.
37. Molnar M, Tongiorgi E, Avignone E, Gonfloni S, Ruberti F, Domenici L, Cattaneo A (1998) The effects of anti-nerve growth factor monoclonal antibodies on developing basal forebrain neurons are transient and reversible. Eur J Neurosci 10:3127-3140.
38. Novak M, Jakes R, Edwards PC, Milstein C, Wishik CM (1991) Difference between the tau protein of Alzheimer's paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51. Proc Natl Acad Sci USA 88:5837-5841.
39. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. London: Academic.
40. Pesavento E, Margotti E, Righi M, Cattaneo A, Domenici L (1999) Blocking the NGF-TrkA interaction rescues the developmental loss of LTP in the rat visual cortex. Role of cholinergic system. Neuron, in press.
41. Piccioli P, Ruberti F, Biocca S, Di Luzio A, Bradbury A, Cattaneo A (1991) Neuroantibodies: molecular cloning of a monoclonal antibody against substance P for expression in the central nervous system. Proc Natl Acad Sci USA 88:5611-5615.
42. Piccioli P, Di Luzio A, Amann R, Schuligoi R, Surani MA, Donnerer J, Cattaneo A (1995) neuroantibodies: ectopic expression of a recombinant anti-substance P antibody in the central nervous system of transgenic mice. Neuron 15:373-384.
43. Radeke MJ, Misko TP, Hsu C, Herzenberg LA, Shooter EM (1987) Gene transfer and molecular cloning of the rat nerve growth factor receptor. Nature 325:593-597.
44. Ruberti F, Bradbury A, Cattaneo A (1993) Cloning and expression of an anti-nerve growth factor (NGF) antibody for studies using the neuroantibody approach. Cell Mol Neurobiol 13:559-568.
45. Ruberti F, Cattaneo A, Bradbury A (1994) The use of the RACE method to clone hybridoma cDNA when V region primers fail. J Immunol Methods 173:33-39.
46. Sieler M, Schwab ME (1984) Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat. Brain Res 300:33-39.
47. Smeyne RJ, Klein R, Schnapp A, Long L K, Bryant S, Lewin A, Lira S A, Barbacid M (1994) Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368:246-249.
48. Tuszynski MH, Armstrong DM, Gage FH (1990) Basal forebrain cell loss following fimbria/fornix transection. Brain Res 508:241-248.
49. Van der Zee CEEM, Ross GM, Riopelle RJ, Hagg T (1996) Survival of cholinergic forebrain neurons in developing p75 NGFR-deficient mice. Science 274:1729-1732.
50. Williams LR, Varon S, Peterson GM, Wictorin K, Fisccher W, Bjorklund A, Gage FH (1986) Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria-fornix transection. Proc Natl Acad Sci USA 83:9231-9235.
51. Winter G, Griffiths AD, Hawkins RE, Hoogenboom HR (1994) Making antibodies by phage display technology. Annu Rev Immunol 12:433-455.
52. Wyatt S, Pinon LG, Ernfors P, Davies AM (1997) Sympathetic neuron survival and TrkA expression in NT3-deficient mouse embryos. EMBO J 16:3115-3123.
53. Yoon SO, Casaccia-Bonnefil P, Carter B, Chao MV (1998) Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival. J Neurosci 18:3273-3281.