Xenopus laevis oocytes expressing human P-glycoprotein: Probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux

Pharmacological Research

Volumn 61, Issue 1, 2010, Pages 76-84

  Jutabha, Promsuk ^a,b   Wempe, Michael F ^c   Anzai, Naohiko ^b   Otomo, Jun ^d   Kadota, Toshihito ^a   Endou, Hitoshi ^a,b  

^a Fuji Biomedix Co Ltd   (Japan)

^b KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF COLORADO   (United States)

^d HITACHI LTD   (Japan)

Author keywords

ABC transporter; Drug efflux; P glycoprotein; Xenopus laevis oocyte

Indexed keywords

ADENOSINE TRIPHOSPHATE; CIMETIDINE; DIGOXIN; DOXORUBICIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; QUINIDINE; TRITIUM; VERAPAMIL; VINBLASTINE SULFATE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG SCREENING; DRUG TRANSPORT; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSPORT KINETICS; XENOPUS LAEVIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; DIGOXIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG INTERACTIONS; FEMALE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; KINETICS; MICROINJECTIONS; OOCYTES; P-GLYCOPROTEIN; QUINIDINE; TEMPERATURE; VERAPAMIL; VINBLASTINE; XENOPUS LAEVIS;

EID: 72749119475     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2009.07.002     Document Type: Article

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