Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes

Journal of Pharmacology and Experimental Therapeutics

Volumn 304, Issue 2, 2003, Pages 589-595

  Aronoff, David M ^a   Boutaud, Olivier ^a   Marnett, Lawrence J ^a   Oates, John A ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; HYDROPEROXIDE; ICOSAPENTAENOIC ACID; PARACETAMOL; PROSTAGLANDIN SYNTHASE; PROTOPORPHYRIN; SALICYLIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ISOENZYME; LIPID PEROXIDE; PEROXIDASE;

ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIPYRETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; ELECTRON TRANSPORT; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; OXIDATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; ANIMAL; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; MALE; METABOLISM; OXIDATION REDUCTION REACTION; SHEEP;

ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; ISOENZYMES; LIPID PEROXIDES; MALE; OXIDATION-REDUCTION; PEROXIDASE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SALICYLIC ACID; SHEEP;

EID: 0037310693     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.042853     Document Type: Article

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