Lipid-soluble 3-pyridinol antioxidants spare α-tocopherol and do not efficiently mediate peroxidation of cholesterol esters in human low-density lipoprotein

Journal of Medicinal Chemistry

Volumn 48, Issue 22, 2005, Pages 6787-6789

  Kim, Hye Young ^a   Pratt, Derek A ^a   Seal, Jennifer R ^a   Wijtmans, Maikel ^a   Porter, Ned A ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYPYRIDINE; ALPHA TOCOPHEROL; ANTIOXIDANT; CHOLESTEROL ESTER; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRYPTOPHAN;

ARTICLE; ATHEROSCLEROSIS; HUMAN; LIPID PEROXIDATION; OXIDATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ALPHA-TOCOPHEROL; ANTIOXIDANTS; HUMANS; LIPID PEROXIDATION; LIPOPROTEINS, LDL; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 27444435355     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0507173     Document Type: Article

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27. Studies of pyridinol oxidation to be published in due course suggest that quinone-imines are among the products formed. The reactivity of these compounds is important with regard to the in vivo efficacy of the compounds.