Retinoic acid enhances prostaglandin E2 production through increased expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in rat brain microglia

Journal of Neuroscience Research

Volumn 86, Issue 6, 2008, Pages 1353-1360

  Kim, Beomsue ^a   Lee, Jee Hyung ^a   Yang, Myung Soon ^a   Jou, Ilo ^a   Joe, Eun Hye ^a,b  

^a Ajou University School of Medicine   (South Korea)

^b NONE   (South Korea)

Author keywords

15d PGJ2; All trans retinoic acid; COX 2; Microglia; mPGES 1; PGE2

Indexed keywords

CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; PROSTAGLANDIN D SYNTHASE; PROSTAGLANDIN D2; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; RETINOIC ACID; THROMBIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; ENCEPHALITIS; MACROPHAGE; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STIMULATION; UPREGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; BRAIN; CELLS, CULTURED; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; INFLAMMATION; INTRAMOLECULAR OXIDOREDUCTASES; LIPOPOLYSACCHARIDES; MICROGLIA; MICROSOMES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THROMBIN; TRETINOIN;

EID: 42449098880     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21593     Document Type: Article

References (35)

1. Akundi RS, Candelario-Jalil E, Hess S, Hull M, Lieb K, Gebicke-Haerter PJ, Fiebich BL. 2005. Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia. Glia 51:199-208.
2. 2 on tumor necrosis factor and interleukin-10 production in microglia: a regulatory loop controlling microglia pro- and anti-inflammatory activities. J Neurosci Res 56:571-580.
3. Block ML, Hong JS. 2005. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 76:77-98.
4. Chambon P. 1996. A decade of molecular biology of retinoic acid receptors. FASEB J 10:940-954.
5. Choi WH, Ji KA, Jeon SB, Yang MS, Kim H, Min KJ, Shong M, Jou I, Joe EH. 2005. Anti-inflammatory roles of retinoic acid in rat brain astrocytes: Suppression of interferon-gamma-induced JAK/STAT phosphorylation. Biochem Biophys Res Commun 329:125-131.
6. Corcoran JP, So PL, Maden M. 2004. Disruption of the retinoid signalling pathway causes a deposition of amyloid beta in the adult rat brain. Eur J Neurosci 20:896-902.
7. Datta PK, Lianos EA. 1999. Retinoic acids inhibit inducible nitric oxide synthase expression in mesangial cells. Kidney Int 56:486-493.
8. Dheen ST, Jun Y, Yan Z, Tay SS, Ling EA. 2005. Retinoic acid inhibits expression of TNF-alpha and iNOS in activated rat microglia. Glia 50:21-31.
9. Enderlin V, Pallet V, Alfos S, Dargelos E, Jaffard R, Garcin H, Higueret P. 1997. Age-related decreases in mRNA for brain nuclear receptors and target genes are reversed by retinoic acid treatment. Neurosci Lett 229:125-129.
10. Fukunaga K, Kohli P, Bonnans C, Fredenburgh LE, Levy BD. 2005. Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury. J Immunol 174:5033-5039.
11. Gilroy DW, Colville-Nash PR, Willis D, drivers J, Paul-Clark MJ, Willoughby DA. 1999. Inducible cyclooxygenase may have anti-inflammatory properties. Nat Med 5:698-701.
12. Giulian D, Baker TJ. 1986. Characterization of ameboid microglia isolated from developing mammalian brain. J Neurosci 6:2163-2178.
13. Goodman AB, Pardee AB. 2003. Evidence for defective retinoid transport and function in late onset Alzheimer's disease. Proc Natl Acad Sci U S A 100:2901-2905.
14. 2 synthesis is differentially affected by reactive nitrogen intermediates in cultured rat microglia and RAW 264.7 cells. FEBS Lett 413:314-318.
15. Guillemin GJ, Brew BJ. 2004. Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. J Leuk Biol 75:388-397.
16. Harizi H, Juzan M, Pitard V, Moreau JF, Gualde N. 2002. Cyclooxygenase-2-issued prostaglandin e(2) enhances the production of endogenous IL-10, which down-regulates dendritic cell functions. J Immunol 168:2255-2263.
17. 2 production. J Neurochem 94:1546-1558.
18. Lane MA, Bailey SJ. 2005. Role of retinoid signalling in the adult brain. Prog Neurobiol 75:275-293.
19. 2 on microglial functions. Biochimie 80:899-904.
20. Mehta K, McQueen T, Tucker S, Pandita R, Aggarwal BB. 1994. Inhibition by all-trans-retinoic acid of tumor necrosis factor and nitric oxide production by peritoneal macrophages. J Leuk Biol 55:336-342.
21. Mey J. 2006. New therapeutic target for CNS injury? The role of retinoic acid signaling after nerve lesions. J Neurobiol 66:757-779.
22. 2, cyclic AMP and non-steroidal anti-inflammatory drugs. Eur J Neurosci 9:934-940.
23. Mohri I, Eguchi N, Suzuki K, Urade Y, Taniike M. 2003. Hematopoietic prostaglandin D synthase is expressed in microglia in the developing postnatal mouse brain. Glia 42:263-274.
24. Motomura K, Sakai H, Isobe H, Nawata H. 1997. Effects of retinoids on the production of tumour necrosis factor-alpha and nitric oxide by lipopolysaccharide-stimulated rat Kupffer cells in vitro: evidence for participation of retinoid X receptor signalling pathway. Cell Biochem Funct 15:95-101.
25. 2 production by stromal cells in the murine small intestine lamina propria: directing the tone of the intestinal immune response. J Immunol 166:4465-4472.
26. Plewig G, Wagner A. 1981. Anti-inflammatory effects of 13-cis-retinoic acid. An in vivo study. Arch Dermatol Res 270:89-94.
27. Pyo H, Jou I, Jung S, Hong S, Joe EH. 1998. Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia. Neuroreport 9:871-874.
28. Reifen R. 2002. Vitamin A as an anti-inflammatory agent. Proc Nutr Soc 61:397-400.
29. Ryu J, Pyo H, Jou I, Joe E. 2000. Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-kappa B. J Biol Chem 275:29955-29959.
30. Twining SS, Schulte DP, Wilson PM, Fish BL, Moulder JE. 1997. Vitamin A deficiency alters rat neutrophil function. J Nutr 127:558-565.
31. 2. Trends Immunol 25:40-46.
32. Waetzig V, Czeloth K, Hidding U, Mielke K, Kanzow M, Brecht S, Goetz M, Lucius R, Herdegen T, Hanisch UK. 2005. c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia. Glia 50:235-246.
33. Witz G, Goldstein BD, Amoruso M, Stone DS, Troll W. 1980. Retinoid inhibition of superoxide anion radical production by human polymorphonuclear leukocytes stimulated with tumor promoters. Biochem Biophys Res Commun 97:883-888.
34. Xu J, Drew PD. 2006. 9-Cis-retinoic acid suppresses inflammatory responses of microglia and astrocytes. J Neuroimmunol 171:135-144.
35. Yang MS, Ji KA, Jeon SB, Jin BK, Kim SU, Jou I, Joe E. 2006. Interleukin-13 enhances cyclooxygenase-2 expression in activated rat brain microglia: implications for death of activated microglia. J Immunol 177:1323-1329.