Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereus

Journal of the American Chemical Society

Volumn 131, Issue 48, 2009, Pages 17563-17565

  Acker, Michael G ^a   Bowers, Albert A ^a   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC ACTIVITY; BACILLUS CEREUS; CLINICAL USE; GENE REPLACEMENT; IN-VIVO; MACROCYCLIC COMPOUNDS; PHARMACOKINETIC PROPERTIES; POST-TRANSLATIONAL MODIFICATIONS; STRUCTURE ACTIVITY RELATIONSHIPS;

AMINES; ANTIBIOTICS; BACTERIOLOGY;

PEPTIDES;

POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN PRECURSOR;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS CEREUS; BACTERIAL GENE; BIOSYNTHESIS; CARBOXY TERMINAL SEQUENCE; DIFFUSION; GENE CLUSTER; GENE MUTATION; GENE SEQUENCE; GENETIC MANIPULATION; GENETIC VARIABILITY; IN VIVO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BACILLUS CEREUS; GENE KNOCKOUT TECHNIQUES; GENES, BACTERIAL; GENETIC ENGINEERING; MUTATION; PEPTIDES;

EID: 72249098749     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja908777t     Document Type: Article

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