Structure of an EF-Tu complex with a thiazolyl peptide antibiotic determined at 2.35 Å resolution: Atomic basis for GE2270A inhibition of EF- Tu

Biochemistry

Volumn 39, Issue 1, 2000, Pages 37-45

  Heffron, Susan E ^a   Jurnak, Frances ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOACYL TRANSFER RNA; ARGININE; ELONGATION FACTOR TU; GE 2270A; GLUTAMIC ACID; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; POLYPEPTIDE ANTIBIOTIC AGENT; THIAZOLE DERIVATIVE;

AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DRUG BINDING SITE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SOLUBILITY; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

ANTI-BACTERIAL AGENTS; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; MODELS, MOLECULAR; PEPTIDE ELONGATION FACTOR TU; PEPTIDES; PROTEIN CONFORMATION; THIAZOLES;

EID: 0034635128     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9913597     Document Type: Article

References (58)

1. Abel, K., and Jurnak, F. (1996) Structure 4, 229-238.
2. Abel, K., Yoder, M. D., Hilgenfeld, R., and Jurnak, F. (1996) Structure 4, 1153-1159.
3. Polekhina, G., Thirup, S., Kjeldgaard, M., Nissen, P., Lippmann, C., and Nyborg, J. (1996) Structure 4, 1141-1151.
4. Kawashima, T., Berthet-Colominas, C., Wulff, M., Cusack, S., and Leberman, R. (1996) Nature 379, 511-518.
5. Nissen, P., Kjeldgaard, M., Thirup, S., Polekhina, G., Reshetnikova, L., Clark, B. F., and Nyborg, J. (1995) Science 270, 1464-1472.
6. Berchtold, H., Reshetnikova, L., Reiser, C. O., Schirmer, N. K., Sprinzl, M., and Hilgenfeld, R. (1993) Nature 365, 126-132.
7. Kjeldgaard, M., Nissen, P., Thirup, S., and Nyborg, J. (1993) Structure 1, 35-50.
8. Anborgh, P. H., and Parmeggiani, A. (1991) EMBO J. 10, 779-784.
9. Landini, P., Bandera, M., Goldstein, B. P., Ripamonti, F., Soffientini, A., Islam, K., and Denaro, M. (1992) Biochem. J. 283, 649-652.
10. Shimanaka, K., Kinoshita, N., Iinuma, H., Hamada, M., and Takeuchi, T. (1994) J. Antibiot. 47, 668-674.
11. Parmeggiani, A., and Swart, G. W. M. (1985) Annu. Rev. Microbiol. 39, 557-577.
12. Wolf, H., Chinali, G., and Parmeggiani, A. (1977) Eur. J. Biochem. 75, 67-75.
13. Pingoud, A., Block, W., Urbanke, C., and Wolf, H. (1982) Eur. J. Biochem. 78, 403-409.
14. Cetin, R., Krab, I. M., Anborgh, P. H., Cool. R. H., Watanabe, T., Sugiyama, T., Izake, K., and Parmeggiani, A. (1996) EMBO J. 15, 2604-2611.
15. Selva, E., Beretta, G., Montanini, N., Saddler, G. S., Gastaldo, L., Ferrari, P., Lorenzetti, R., Landini, P., Ripamonti, F., Goldstein, B. P., Berti, M., Montanaro, L., and Denaro, M. (1991) J. Antibiot. 44, 693-701.
16. Stella, S., Montanini, N., LeMonnier, F., Ferrari, P., Colombo, L., Landini, P., Ciciliato, I., Goldstein, B. P., Selva, E., and Denaro, M. (1995) J. Antibiot. 48, 780-786.
17. Gale, E. F., Cundliffe, E., Reynolds, P. E., Richmond, M. H., and Waring, M. J. (1981) in The Molecular Basis of Antibiotic Action, pp 492-500, John Wiley & Sons, London.
18. Cundliffe, E., and Thompson, J. (1981) J. Gen. Microbiol. 126, 185-192.
19. Cundliffe, E., and Thompson, J. (1981 ) Eur. J. Biochem. 118, 47-52.
20. Vazquez, D. (1979) Mol. Biol. Biochem. Biophys. 30, 1-312.
21. Cundliffe, E. (1989) Annu. Rev. Microbiol. 43, 207-233.
22. Cundliffe, E. (1978) Nature 272, 792-795.
23. Sosia, M., Amati, G., Cappellano, C., Sarubbi, E., Monti, F., and Donadio, S. (1996) Mol. Microbiol. 22, 43-51.
24. Möhrle, V. G., Tieleman, L. N., and Kraal, B. (1997) Biochem. Biophys. Res. Commun. 230, 320-326.
25. Goldstein, B. P., Berti, M., Ripamonti, R., Resconi, A., Scotti, R., and Denaro, M. (1993) Antimicrob. Agents Chemother. 37, 741-745.
26. Shimanaka, K., Iinuma, H., and Hamada, M. (1995) J. Antibiot. 48, 182-184.
27. Anborgh, P. H., and Parmeggiani, A. (1993) J. Biol. Chem. 268, 24622-24628.
28. Louie, A., Ribeiro, N. S., Reid, B. R., and Jurnak, F. (1984) J. Biol. Chem. 259, 5010-5016.
29. Kabsch, W. (1993) J. Appl. Ctystallogr. 24, 795-800.
30. Campbell, J. W. (1995) J. Appl. Crystallogr. 28, 236-242.
31. Evans, P. R. (1997) Joint CCP4 and ESF-EACBM Newsletter 33, 22-24.
32. French, G. S., and Wilson, K. S. (1978) Acta Crystallogr. A34, 517-525.
33. Brunger, A. T. (1992) X-PLOR, version 3.1, Yale University Press, New Haven, CT.
34. Huber, R. (1965) Acta Crystallogr. A19, 353-356.
35. Steigemann, W. (1974) Ph.D. Thesis, Technische Universitaet Muenchen, Muenchen, Germany.
36. Brunger, A. T. (1990) Acta Crystallogr. A46, 46-57.
37. Fujinaga, M., and Read, R. J. (1987) J. Appl. Crystallogr. 20, 517-521.
38. DeLano, W. L., and Brunger, A. T. (1995) Acta Crystallogr. D51, 740-748.
39. Brunger, A. T. (1992) Nature 355, 472-474.
40. Engh, R. A., and Huber, R. (1991) Acta Crystallogr. A47, 392-400.
41. Parkinson, G., Vojtechovsky, J., Clowney, L., Brünger, A. T., and Berman, H. M. (1996) Acta Crystallogr. D552, 57-64.
42. Jiang, J.-S., and Brünger, A. T. (1994) J. Mol. Biol. 243, 100-115.
43. Brünger, A. T., Kuriyan, J., and Karplus, M. (1987) Science 235, 458-460.
44. Brünger, A. T., Krukowski, A., and Erickson, J. (1990) Acta Crystallogr. A46, 585-593.
45. Read, R. J. (1986) Acta Crystallogr. A42, 140-149.
46. Kettenring, J., Colombo, L., Ferrari, P., Tavecchia, P., Nebuloni, M., Vékey, K., Gallo, G. G., and Selva, E. (1991) J. Antibiot. 44, 702-715.
47. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. A47, 110-119.
48. Kleywegt, G. J. (1995) CCP4/ESF-EACBM Newsletter on Protein Crystallography 31, 45-50.
49. Brònger, A. T., Adams, P. D., Clore, G. M., Delano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J.-S., Kuszewski, J., Nilges, N., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D54, 905-921.
50. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291.
51. Ohama, T., Yamao, F., Muto, A., and Osawa, S. (1987) J. Bacteriol. 169, 4770-4777.
52. Van Wezel, G. P., Woudt, L. P., Vervenne, R., Verdurmen, M. L., Vijgenboom, E., and Bosch, L. (1994) Biochim. Biophys. Acta 1219, 543-547.
53. Alkaradaghi, S., Evarsson, A., Garger, M., Zheltonosova, J., and Liljas, A. (1996) Structure 4, 555-565.
54. Corpet, F., Gouzy, J., and Kahn, D. (1999) Nucleic Acids Res. 27, 263-267.
55. Anderson, B., Hodgkin, D. C., and Viswamitra, M. A. (1970) Nature 225, 233-235.
56. Evans, S. V. (1993) J. Mol. Graphics 11, 134-138.
57. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.
58. Merritt, E. A., and Bacon, D. J. (1997) Methods Enzymol. 277, 505-542.