-
2
-
-
0026557343
-
Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women
-
Early Breast Cancer Trialists' Collaborative Group
-
Early Breast Cancer Trialists' Collaborative Group. Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Lancet 1992;339:1-15.
-
(1992)
Lancet
, vol.339
, pp. 1-15
-
-
-
3
-
-
0036467847
-
Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over study
-
DOI 10.1200/JCO.20.3.751
-
Geisler J, Haynes B, Anker G, Dowsett M, Lonning PE. Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over study. J Clin Oncol 2002;20: 751-757 (Pubitemid 34111382)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.3
, pp. 751-757
-
-
Geisler, J.1
Haynes, B.2
Anker, G.3
Dowsett, M.4
Lonning, P.E.5
-
4
-
-
0031663593
-
In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients
-
Geisler J, King N, Anker G, et al. In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients. Clin Cancer Res 1998;4:2089-2093
-
(1998)
Clin Cancer Res
, vol.4
, pp. 2089-2093
-
-
Geisler, J.1
King, N.2
Anker, G.3
-
5
-
-
49649111492
-
Genome-wide analysis of aromatase inhibitor-resistant, tamoxifen-resistant, and long-term estrogen-deprived cells reveals a role for estrogen receptor
-
Masri S, Phung S, Wang X, et al. Genome-wide analysis of aromatase inhibitor-resistant, tamoxifen-resistant, and long-term estrogen-deprived cells reveals a role for estrogen receptor. Cancer Res 2008;68:4910-4918
-
(2008)
Cancer Res
, vol.68
, pp. 4910-4918
-
-
Masri, S.1
Phung, S.2
Wang, X.3
-
6
-
-
0042232592
-
Enhanced estrogen receptor (ER) α, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation
-
DOI 10.1074/jbc.M305226200
-
Martin LA, Farmer I, Johnston SR, Ali S, Marshall C, Dowsett M. Enhanced estrogen receptor (ER) α, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation. J Biol Chem 2003;278:30458-30468 (Pubitemid 36994549)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.33
, pp. 30458-30468
-
-
Martin, L.-A.1
Farmer, I.2
Johnston, S.R.D.3
Ali, S.4
Marshall, C.5
Dowsett, M.6
-
7
-
-
0035971181
-
Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor α: A new model for anti-estrogen resistance
-
DOI 10.1074/jbc.M010840200
-
Campbell RA, Bhat-Nakshatri P, Patel NM, Constantinidou D, Ali S, Nakshatri H. Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor α: a new model for anti-estrogen resistance. J Biol Chem 2001;276:9817-9824 (Pubitemid 37391881)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.13
, pp. 9817-9824
-
-
Campbell, R.A.1
Bhat-Nakshatri, P.2
Patel, N.M.3
Constantinidou, D.4
Ali, S.5
Nakshatri, H.6
-
8
-
-
0028886694
-
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
-
New York, NY
-
Kato S, Endoh H, Masuhiro Y, et al. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science (New York, NY) 1995; 270:1491-1494
-
(1995)
Science
, vol.270
, pp. 1491-1494
-
-
Kato, S.1
Endoh, H.2
Masuhiro, Y.3
-
9
-
-
18144387234
-
The role of growth factor receptor pathways in human breast cancer cells adapted to long-term estrogen deprivation
-
DOI 10.1158/0008-5472.CAN-04-4092
-
Sabnis GJ, Jelovac D, Long B, Brodie A. The role of growth factor receptor pathways in human breast cancer cells adapted to long-term estrogen deprivation. Cancer Res 2005;65:3903-3910 (Pubitemid 40616372)
-
(2005)
Cancer Research
, vol.65
, Issue.9
, pp. 3903-3910
-
-
Sabnis, G.J.1
Jelovac, D.2
Long, B.3
Brodie, A.4
-
10
-
-
0034526749
-
A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I
-
Martin MB, Franke TF, Stoica GE, et al. A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I. Endocrinology 2000;141:4503-4511
-
(2000)
Endocrinology
, vol.141
, pp. 4503-4511
-
-
Martin, M.B.1
Franke, T.F.2
Stoica, G.E.3
-
11
-
-
0029877913
-
Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
-
Bunone G, Briand PA, Miksicek RJ, Picard D. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J 1996;15:2174-2183 (Pubitemid 26141134)
-
(1996)
EMBO Journal
, vol.15
, Issue.9
, pp. 2174-2183
-
-
Bunone, G.1
Briand, P.-A.2
Miksicek, R.J.3
Picard, D.4
-
12
-
-
0031594574
-
Pp90(rsk1) regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167
-
Joel PB, Smith J, Sturgill TW, Fisher TL, Blenis J, Lannigan DA. pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. Mol Cell Biol 1998;18:1978-1984 (Pubitemid 28152646)
-
(1998)
Molecular and Cellular Biology
, vol.18
, Issue.4
, pp. 1978-1984
-
-
Joel, P.B.1
Smith, J.2
Sturgill, T.W.3
Fisher, T.L.4
Blenis, J.5
Lannigan, D.A.6
-
13
-
-
0029992278
-
Molecular chaperones in cellular protein folding
-
Hartl FU. Molecular chaperones in cellular protein folding. Nature 1996;381:571-579
-
(1996)
Nature
, vol.381
, pp. 571-579
-
-
Hartl, F.U.1
-
15
-
-
0021708673
-
Quantitation and intracellular localization of the 85K heat shock protein by using monoclonal and polyclonal antibodies
-
Lai BT, Chin NW, Stanek AE, Keh W, Lanks KW. Quantitation and intracellular localization of the 85K heat shock protein by using monoclonal and polyclonal antibodies. Mol Cell Biol 1984;4:2802-2810
-
(1984)
Mol Cell Biol
, vol.4
, pp. 2802-2810
-
-
Lai, B.T.1
Chin, N.W.2
Stanek, A.E.3
Keh, W.4
Lanks, K.W.5
-
16
-
-
0028970484
-
Differential expression of Mr 70,000 heat shock protein in normal, premalignant, and malignant human uterine cervix
-
Ralhan R, Kaur J. Differential expression of Mr 70,000 heat shock protein in normal, premalignant, and malignant human uterine cervix. Clin Cancer Res 1995;1: 1217-1222
-
(1995)
Clin Cancer Res
, vol.1
, pp. 1217-1222
-
-
Ralhan, R.1
Kaur, J.2
-
17
-
-
17144377442
-
Hsp90 activation and cell cycle regulation
-
Burrows F, Zhang H, Kamal A. Hsp90 activation and cell cycle regulation. Cell Cycle 2004;3:1530-1536 (Pubitemid 40521406)
-
(2004)
Cell Cycle
, vol.3
, Issue.12
, pp. 1530-1536
-
-
Burrows, F.1
Zhang, H.2
Kamal, A.3
-
18
-
-
4143153881
-
Hsp90: An emerging target for breast cancer therapy
-
DOI 10.1097/01.cad.0000136876.11928.be
-
Beliakoff J, Whitesell L. Hsp90: an emerging target for breast cancer therapy. Anticancer Drugs 2004;15: 651-662 (Pubitemid 39099914)
-
(2004)
Anti-Cancer Drugs
, vol.15
, Issue.7
, pp. 651-662
-
-
Beliakoff, J.1
Whitesell, L.2
-
19
-
-
0028064940
-
Inhibition of heat shock protein HSP90-pp60(v-src) heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
-
Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM. Inhibition of heat shock protein HSP90-60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci U S A 1994;91:8324-8328 (Pubitemid 24273656)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.18
, pp. 8324-8328
-
-
Whitesell, L.1
Mimnaugh, E.G.2
De Costa, B.3
Myers, C.E.4
Neckers, L.M.5
-
21
-
-
0031875042
-
The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin
-
DOI 10.1007/s002800050817
-
Schulte TW, Neckers LM. The benzoquinone ansamycin 17-allylamino-17- demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin. Cancer Chemother Pharmacol 1998;42: 273-279 (Pubitemid 28393843)
-
(1998)
Cancer Chemotherapy and Pharmacology
, vol.42
, Issue.4
, pp. 273-279
-
-
Schulte, T.W.1
Neckers, L.M.2
-
23
-
-
0036139023
-
1 mice and fischer 344 rats
-
DOI 10.1007/s00280-001-0380-8
-
Egorin MJ, Lagattuta TF, Hamburger DR, et al. Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17- demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats. Cancer Chemother Pharmacol 2002;49:7-19. (Pubitemid 34045264)
-
(2002)
Cancer Chemotherapy and Pharmacology
, vol.49
, Issue.1
, pp. 7-19
-
-
Egorin, M.J.1
Lagattuta, T.F.2
Hamburger, D.R.3
Covey, J.M.4
White, K.D.5
Musser, S.M.6
Eiseman, J.L.7
-
24
-
-
33745888997
-
17-dimethylaminoethylamino-17-demethoxygeldanamycin in patients with advanced-stage solid tumors and lymphoma: A phase I study
-
Shadad FN, Ramanathan RK. 17-Dimethylaminoethylamino-17- demethoxygeldanamycin in patients with advanced-stage solid tumors and lymphoma: a phase I study. Clin Lymph Myeloma 2006;6:500-501 (Pubitemid 44043543)
-
(2006)
Clinical Lymphoma and Myeloma
, vol.6
, Issue.6
, pp. 500-501
-
-
Shadad, F.N.1
Ramanathan, R.K.2
-
25
-
-
0141484615
-
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
-
DOI 10.1038/nature01913
-
Kamal A, Thao L, Sensintaffar J, et al. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 2003;425:407-410 (Pubitemid 37187270)
-
(2003)
Nature
, vol.425
, Issue.6956
, pp. 407-410
-
-
Kamal, A.1
Thao, L.2
Sensintaffar, J.3
Zhang, L.4
Boehm, M.F.5
Fritz, L.C.6
Burrows, F.J.7
-
26
-
-
0025089197
-
Stable expression of human aromatase complementary DNA in mammalian cells: A useful system for aromatase inhibitor screening
-
Zhou DJ, Pompon D, Chen SA. Stable expression of human aromatase complementary DNA in mammalian cells: a useful system for aromatase inhibitor screening. Cancer Res 1990;50:6949-6954 (Pubitemid 20361096)
-
(1990)
Cancer Research
, vol.50
, Issue.21
, pp. 6949-6954
-
-
Zhou, D.1
Pompon, D.2
Chen, S.3
-
27
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984; 22:27-55.
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 27-55
-
-
Chou, T.C.1
Talalay, P.2
-
28
-
-
0030931876
-
Caspases: The executioners of apoptosis
-
Cohen GM. Caspases: the executioners of apoptosis. Biochem J 1997;326:1-16.
-
(1997)
Biochem J
, vol.326
, pp. 1-16
-
-
Cohen, G.M.1
-
29
-
-
0032887942
-
Involvement of steroid hormone and growth factor cross-talk in endocrine response in breast cancer
-
Nicholson RI, McClelland RA, Robertson JF, Gee JM. Involvement of steroid hormone and growth factor cross-talk in endocrine response in breast cancer. Endocr Relat Cancer 1999;6:373-387
-
(1999)
Endocr Relat Cancer
, vol.6
, pp. 373-387
-
-
Nicholson, R.I.1
McClelland, R.A.2
Robertson, J.F.3
Gee, J.M.4
-
31
-
-
18344390418
-
ERBB receptors and cancer: The complexity of targeted inhibitors
-
DOI 10.1038/nrc1609
-
Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev 2005;5:341-354 (Pubitemid 40637826)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.5
, pp. 341-354
-
-
Hynes, N.E.1
Lane, H.A.2
-
32
-
-
0142188139
-
Hormone-Refractory Breast Cancer Remains Sensitive to the Antitumor Activity of Heat Shock Protein 90 Inhibitors
-
Beliakoff J, Bagatell R, Paine-Murrieta G, Taylor CW, Lykkesfeldt AE, Whitesell L. Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors. Clin Cancer Res 2003;9:4961-4971 (Pubitemid 37323303)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.13
, pp. 4961-4971
-
-
Beliakoff, J.1
Bagatell, R.2
Paine-Murrieta, G.3
Taylor, C.W.4
Lykkesfeldt, A.E.5
Whitesell, L.6
-
33
-
-
33644694046
-
Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1
-
DOI 10.1016/j.imlet.2005.11.018, PII S0165247805003639, Signal and Signaling Processing in the Immune System
-
Zsebik B, Citri A, Isola J, Yarden Y, Szollosi J, Vereb G. Hsp90 inhibitor 17-AAG reduces ErbB2levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1. Immunol Lett 2006;104:146-155 (Pubitemid 43330721)
-
(2006)
Immunology Letters
, vol.104
, Issue.1-2
, pp. 146-155
-
-
Zsebik, B.1
Citri, A.2
Isola, J.3
Yarden, Y.4
Szollosi, J.5
Vereb, G.6
-
34
-
-
21744462772
-
Synergistic activity of imatinib and 17-AAG in imatinib-resistant CML cells overexpressing BCR-ABL - Inhibition of P-glycoprotein function by 17-AAG
-
DOI 10.1038/sj.leu.2403764
-
Radujkovic A, Schad M, Topaly J, et al. Synergistic activity of imatinib and 17-AAG in imatinib-resistant CML cells overexpressing BCR-ABL-Inhibition of Pglycoprotein function by 17-AAG. Leukemia 2005;19: 1198-1206 (Pubitemid 40946004)
-
(2005)
Leukemia
, vol.19
, Issue.7
, pp. 1198-1206
-
-
Radujkovic, A.1
Schad, M.2
Topaly, J.3
Veldwijk, M.R.4
Laufs, S.5
Schultheis, B.S.6
Jauch, A.7
Melo, J.V.8
Fruehauf, S.9
Zeller, W.J.10
-
35
-
-
35948977339
-
Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1α autocrine loop, and reduces orthotopic tumor growth
-
DOI 10.1158/1078-0432.CCR-07-1104
-
Lang SA, Moser C, Gaumann A, et al. Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1α autocrine loop, and reduces orthotopic tumor growth. Clin Cancer Res 2007;13:6459-6468 (Pubitemid 350075036)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.21
, pp. 6459-6468
-
-
Lang, S.A.1
Moser, C.2
Gaumann, A.3
Klein, D.4
Glockzin, G.5
Popp, F.C.6
Dahlke, M.H.7
Piso, P.8
Schlitt, H.J.9
Geissler, E.K.10
Stoeltzing, O.11
-
36
-
-
34147123235
-
Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo
-
DOI 10.1158/1535-7163.MCT-06-0628
-
Lang SA, Klein D, Moser C, et al. Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo. Mol Cancer Ther 2007;6:1123-1132 (Pubitemid 46554583)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.3
, pp. 1123-1132
-
-
Lang, S.A.1
Klein, D.2
Moser, C.3
Gaumann, A.4
Glockzin, G.5
Dahlke, M.H.6
Dietmaier, W.7
Bolder, U.8
Schlitt, H.J.9
Geissler, E.K.10
Stoeltzing, O.11
-
37
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell- Intrinsic death machinery
-
DOI 10.1016/S0092-8674(00)80405-5
-
Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997;91:231-241 (Pubitemid 27456390)
-
(1997)
Cell
, vol.91
, Issue.2
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Xu, T.3
Masters, S.4
Haian, F.5
Gotoh, Y.6
Greenberg, M.E.7
-
38
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone MH, Roy N, Stennicke HR, et al. Regulation of cell death protease caspase-9 by phosphorylation. Science (New York, NY) 1998;282:1318-1321 (Pubitemid 28524494)
-
(1998)
Science
, vol.282
, Issue.5392
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
Salvesen, G.S.4
Franke, T.F.5
Stanbridge, E.6
Frisch, S.7
Reed, J.C.8
-
39
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 1999;96:857-868 (Pubitemid 29165088)
-
(1999)
Cell
, vol.96
, Issue.6
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
40
-
-
12344327270
-
17-Allyamino-17-demethoxygeldanamycin and 17-NN-dimethyl ethylene diamine-geldanamycin have cytotoxic activity against multiple gynecologic cancer cell types
-
DOI 10.1016/j.ygyno.2004.10.009, PII S0090825804008236
-
Gossett DR, Bradley MS, Jin X, Lin J. 17-Allyamino-17- demethoxygeldanamycin and 17-NN-dimethyl ethylene diamine-geldanamycin have cytotoxic activity against multiple gynecologic cancer cell types. Gynecol Oncol 2005;96:381-388 (Pubitemid 40127138)
-
(2005)
Gynecologic Oncology
, vol.96
, Issue.2
, pp. 381-388
-
-
Gossett, D.R.1
Bradley, M.S.2
Jin, X.3
Lin, J.4
-
41
-
-
33751258936
-
Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines
-
DOI 10.1158/1078-0432.CCR-06-1178
-
Robles AI, Wright MH, Gandhi B, et al. Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17- demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines. Clin Cancer Res 2006;12:6547-6556 (Pubitemid 44799730)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.21
, pp. 6547-6556
-
-
Robles, A.I.1
Wright, M.H.2
Gandhi, B.3
Feis, S.S.4
Hanigan, C.L.5
Wiestner, A.6
Varticovski, L.7
-
42
-
-
0032491579
-
Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway
-
DOI 10.1074/jbc.273.45.29864
-
Muise-Helmericks RC, Grimes HL, Bellacosa A, Malstrom SE, Tsichlis PN, Rosen N. Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem 1998;273:29864-29872 (Pubitemid 28510001)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.45
, pp. 29864-29872
-
-
Muise-Helmericks, R.C.1
Grimes, H.L.2
Bellacosa, A.3
Malstrom, S.E.4
Tsichlis, P.N.5
Rosent, N.6
-
43
-
-
0037335034
-
How the ubiquitin-proteasome system controls transcription
-
DOI 10.1038/nrm1049
-
Muratani M, Tansey WP. How the ubiquitin-proteasome system controls transcription. Nat Rev Mol Cell Biol 2003;4:192-201. (Pubitemid 36288041)
-
(2003)
Nature Reviews Molecular Cell Biology
, vol.4
, Issue.3
, pp. 192-201
-
-
Muratani, M.1
Tansey, W.P.2
|